Possible importance of Cannabis sativa L. in regulation of insulin and IL-6R/MAO-A in cancer cell progression and migration of breast cancer patients with diabetes

Bala, Asis; Matsabisa, Motlalepula G.

doi:10.17159/sajs.2018/a0279

Cited by 6 publications

(1 citation statement)

References 18 publications

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“…The insulin receptor is frequently overexpressed in human breast tumors, and this overexpression can change the phenotypic of human breast mammary cells [17]. Insulin is a major factor in both type-2 diabetes and cancer.…”

Section: Resultsmentioning

confidence: 99%

Assessment of Insulin and Cortisol Levels in Iraqi Women with Breast Cancer

JarAllah

Al-Fartusie

Zageer

2023

Al-Mustansiriyah Journal of Science

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Hormones are thought to primarily influence cancer risk by regulating the pace of cell division, cell differentiation, and the amount of cancer-vulnerable cells. Higher insulin levels and cortisol have been linked to some cancers, including breast cancer. Here, we evaluated the relationship between insulin and cortisol signaling and cancer, as well as the effect of these two hormones on organs, subcellular elements, and the process of carcinogenesis. We also consider the time points to prevent and cure breast cancer in insulin signaling. The ultimate objective is to enhance general health. Insulin and cortisol levels were tested and the results showed much higher insulin levels in breast cancer patients compared with control (p<0.001), whereas cortisol levels tested were lower in breast cancer patients compared with control with no statistically significant changes (p>0.05).

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Section: Resultsmentioning

confidence: 99%

Assessment of Insulin and Cortisol Levels in Iraqi Women with Breast Cancer

JarAllah

Al-Fartusie

Zageer

2023

Al-Mustansiriyah Journal of Science

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Protein Kinase C (PKC)-mediated TGF-β Regulation in Diabetic Neuropathy: Emphasis on Neuro-inflammation and Allodynia

Changkakoti,

Das,

Borah

et al. 2024

EMIDDT

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Abstract:: According to the World Health Organization (WHO), diabetes has been increasing steadily over the past few decades. In developing countries, it is the cause of increased morbidity and mortality. Diabetes and its complications are associated with education, occupation, and income across all levels of socioeconomic status. Factors, such as hyperglycemia, social ignorance, lack of proper health knowledge, and late access to medical care, can worsen diabetic complications. Amongst the complications, neuropathic pain and inflammation are considered the most common causes of morbidity for common populations. This review is focused on exploring protein kinase C (PKC)-mediated TGF-β regulation in diabetic complications with particular emphasis on allodynia. The role of PKC-triggered TGF-β in diabetic neuropathy is not well explored. This review will provide a better understanding of the PKC-mediated TGF-β regulation in diabetic neuropathy with several schematic illustrations. Neuroinflammation and associated hyperalgesia and allodynia during microvascular complications in diabetes are scientifically illustrated in this review. It is hoped that this review will facilitate biomedical scientists to better understand the etiology and target drugs effectively to manage diabetes and diabetic neuropathy.

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Role of Nuclear Factor Erythroid 2-Related Factor 2 (NRF-2) Mediated Antioxidant Response on the Synergistic Antitumor Effect of L-Arginine and 5-Fluro Uracil (5FU) in Breast Adenocarcinoma

Bala

Panditharadyula

2019

CPD

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Breast adenocarcinoma (BAC) in glandular tissue cells have excessive metastasis and invasion capability. The major challenges for the chemotherapy used for the management of BAC include chemoresistance and auto-immunosuppression in BAC. The 5-fluro uracil (5-FU) based therapy promotes the immune activation in BAC by targeting the regulatory T cells and myeloid-derived suppressor cells (MDSC). The beneficial effect of the combination of L-Arginine with 5-FU strives to be established in different pre-clinical and clinical conditions and explored in the scientific literature. L-Arginine induces NO production and potentiates the anticancer effect of 5-FU. NO-mediated signaling is regulated by nuclear factor erythroid 2-related factor 2 (NRF-2) mediated antioxidant response. NRF-2 mediated antioxidant mechanism always suppresses the formation of superoxide (O2 -) as well as other reactive oxygen species (ROS). Thus the utilization of NO by O2 - will be minimum in this combination therapy. The regulatory role of NRF-2 in regulation to Antioxidant Response Element (ARE) mediated cytoprotective gene expression in BAC remains unexplored. The present review summarizes the role of NRF-2 mediated antioxidant response on the synergistic antitumor effect of L-Arginine and 5-FU in BAC. This review brought new insight into the management of BAC and in the same context, a hypothesis is raised on the use of reduced glutathione (GSH) or N-Acetyl Cysteine as it may be an added adjuvant in the combination of 5- FU and L-Arginine for management of BAC.

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Possible importance of Cannabis sativa L. in regulation of insulin and IL-6R/MAO-A in cancer cell progression and migration of breast cancer patients with diabetes

Cited by 6 publications

References 18 publications

Assessment of Insulin and Cortisol Levels in Iraqi Women with Breast Cancer

Assessment of Insulin and Cortisol Levels in Iraqi Women with Breast Cancer

Protein Kinase C (PKC)-mediated TGF-β Regulation in Diabetic Neuropathy: Emphasis on Neuro-inflammation and Allodynia

Role of Nuclear Factor Erythroid 2-Related Factor 2 (NRF-2) Mediated Antioxidant Response on the Synergistic Antitumor Effect of L-Arginine and 5-Fluro Uracil (5FU) in Breast Adenocarcinoma

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