Possible important roles of galectins in the healing of human fetal membranes

Chen, Jiale; Chen, Yu; Xu, Dexiang; Chen, Daozhen

doi:10.3389/fendo.2022.941029

Cited by 3 publications

(1 citation statement)

References 73 publications

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“…Galectins act in the immune response at the amniotic interface, stimulate monocytes to enhance the expression levels of Akt, PI3K, and PPAR-γ, and turn on the M2 polarization of macrophages. Galectins interact with epithelial-mesenchymal transition, which induces a healing mechanism [68].…”

Section: Discussionmentioning

confidence: 99%

Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches

et al. 2023

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There is still no curative treatment for the spontaneous preterm prelabor rupture of membranes (sPPROM), the main cause of premature birth. Here, we summarize the most recent methods and materials used for sealing membranes after sPPROM. A literature search was conducted between 2013 and 2023 on reported newborns after membranes were sealed or on animal or tissue culture models. Fourteen studies describing the outcomes after using an amniopatch, an immunologic sealant, or a mechanical cervical adapter were included. According to these studies, an increase in the volume of amniotic fluid and the lack of chorioamnionitis demonstrate a favorable neonatal outcome, with a lower incidence of respiratory distress syndrome and early neonatal sepsis, even if sealing is not complete and stable. In vivo and in vitro models demonstrated that amniotic stem cells, in combination with amniocytes, can spontaneously repair small defects; because of the heterogenicity of the data, it is too early to draw a thoughtful conclusion. Future therapies should focus on materials and methods for sealing fetal membranes that are biocompatible, absorbable, available, easy to apply, and easily adherent to the fetal membrane.

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Section: Discussionmentioning

confidence: 99%

Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches

et al. 2023

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Galectin‐1 Elicits a Tissue‐Specific Anti‐Inflammatory and Anti‐Degradative Effect Upon LPS‐Induced Response in an Ex Vivo Model of Human Fetal Membranes Modeling an Intraamniotic Inflammation

Hernández‐Rodríguez,

Pérez‐Hernández,

Flores‐Espinosa

et al. 2024

American J Rep Immunol

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ProblemIntrauterine infection is one of the most jeopardizing conditions associated with adverse outcomes, including preterm birth; however, multiple tolerance mechanisms operate at the maternal–fetal interface to avoid the rejection of the fetus. Among the factors that maintain the uterus as an immunoprivileged site, Galectin‐1 (Gal‐1), an immunomodulatory glycan‐binding protein secreted by the maternal‐fetal unit, is pivotal in promoting immune cell homeostasis. This work aimed to evaluate the role of Gal‐1 during a lipopolysaccharide (LPS)‐induced‐inflammatory milieu.Method of StudyUsing an ex vivo culture with two independent compartments, human fetal membranes at term were pretreated with 40 and 80 ng/mL of Gal‐1, then to reproduce an intraamniotic inflammation, the fetal side of membranes was stimulated with 500 ng/mL of LPS for 24 h. The concentrations of tumor necrosis factor (TNF)‐α, interleukin (IL)‐1β, IL‐6, monocyte chemoattractant protein (MCP1), macrophage inflammatory protein (MIP1) α, regulated upon activation normal T cell expressed and secreted (RANTES), and matrix metalloproteinase (MMP)‐9 were measured in both amnion and choriodecidua compartments.ResultsIn a tissue‐specific fashion profile, pretreatment with the physiologic concentration of Gal‐1 significantly diminished the LPS‐dependent secretion of TNF‐α, IL‐1β, Il‐6, MCP1, MIP1α, RANTES, and MMP‐9.ConclusionGal‐1 elicits an anti‐inflammatory effect on the human fetal membranes stimulated with LPS, which supports the hypothesis that Gal‐1 is part of the immunomodulatory mechanisms intended to stop the harmful effect of inflammation of the maternal–fetal interface.

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Escherichia coli induced matrix metalloproteinase-9 activity and type IV collagen degradation is regulated by progesterone in human maternal decidual

Bautista-Bautista,

Salguero-Zacarias,

Villeda-Gabriel

et al. 2024

BMC Pregnancy Childbirth

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Possible important roles of galectins in the healing of human fetal membranes

Cited by 3 publications

References 73 publications

Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches

Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible? A Review of Potentially Curative Approaches

Galectin‐1 Elicits a Tissue‐Specific Anti‐Inflammatory and Anti‐Degradative Effect Upon LPS‐Induced Response in an Ex Vivo Model of Human Fetal Membranes Modeling an Intraamniotic Inflammation

Escherichia coli induced matrix metalloproteinase-9 activity and type IV collagen degradation is regulated by progesterone in human maternal decidual

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