ObjectivesThe risk of viral transmission associated with contact sports such as Football during the COVID-19 pandemic is unknown. The aim of this study was to describe the development of infective and immune status of professional football players, team staff and league officials over a truncated football season resumed at the height of the Covid-19 pandemic in a country with high infection rates and to investigate the clinical symptoms related to Covid-19 infection in professional football players.MethodsProspective cohort study of 1337 football players, staff and officials during a truncated football season (9 weeks) with a tailored infection control program based on preventive measures and regular SarS-CoV-2 PCR swab testing (every 3-5 days) combined with serology testing for immunity (every 4 weeks). Clinical symptoms in positive participants were recorded using a 26-item, Likert-scale-based scoring system.ResultsDuring the study period, 85 subjects returned positive (cycle threshold (cT)<30) or reactive (30<cT<40) PCR tests, of which 36 were players. The infection rate was in line with that of the general population at the time. More than half of the infected were asymptomatic, the remaining had only mild symptoms, no one required hospitalization. Symptom severity was associated to lower cT values. Social contacts and family were the most common sources of infection, no infection could be traced to training or matches.ConclusionSports played outdoors involving close contact between athletes represent a limited risk for SARS-CoV-2 infection and severe illness when preventive measures are in place.