Designer 2D materials where the constituent layers are not aligned may result in band structures with dispersionless, "flat" bands. Twisted bilayer graphene has been found to show correlated phases as well as superconductivity related to such flat bands. In parallel, theory work has discovered that superconductivity and superfluidity is determined by the quantum geometry and topology of the band structure. These recent key developments are merging to a flourishing research topic: understanding the possible connection and ramifications of quantum geometry on the induced superconductivity and superfluidity in moiré multilayer and other flat band systems. This article presents an introduction to how quantum geometry governs superfluidity in platforms including, and beyond, graphene. We explain how a new type of topology discovered in TBG could affect superconductivity, pinpoint the geometric contribution in its Beretzinskii-Kosterlitz-Thouless (BKT) critical temperature, and mention moiré materials beyond TBG. Ultracold gases are introduced as a complementary platform for quantum geometric effects and a comparison is made to moiré materials. An outlook sketches the prospects of twisted multilayer systems in providing the route to room temperature superconductivity.