Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

Kuraishi, Yasushi; Ohtsuka, Eiji; Nakano, Tasuku; Kawai, Sanae; Andoh, Tsugunobu; Nishimura, Hiroshi; Kamimura, Kiyoshi

doi:10.1254/jphs.fp0070404

Cited by 19 publications

(20 citation statements)

References 35 publications

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“…However, the role of leukotrienes or prostaglandins in chronic dermatitis induced by repeated application of oxazolone is unclear so far. It has been reported that the 5-lipoxygenase inhibitor zileuton and the 5-lipoxygenase activating protein inhibitor MK-866 suppress itchassociated behavior induced by several pruritogens in mice (15,35,36). Furthermore, the oxazolone-induced severe scratching behavior was completely suppressed by pretreatment with zileuton, but not the cyclooxygenase inhibitor indomethacin or the platelet-activating factor-receptor antagonist YM264.…”

Section: Discussionmentioning

confidence: 98%

Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice

2010

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Abstract. We investigated pharmacological characteristics of the itch-associated response to chronic dermatitis induced by 4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (oxazolone) repeated application in mice. Application of an oxazolone challenge to mice with oxazolone-induced chronic dermatitis evoked severe and transient scratching behavior for up to 1h. Thereafter, mild and continuous scratching behavior was observed for at least 8 h. Both severe and continuous scratching behaviors were suppressed by the opioid-receptor antagonist naltrexone, but not by the H 1 histamine-receptor antagonist fexofenadine, 5-hydroxytryptamine-2 (5-HT 2 )-receptor antagonist methysergide, NK 1 -receptor antagonist LY303870, cyclooxygenase inhibitor indomethacin, or the platelet-activating factor-receptor antagonist YM264. The severe scratching behavior was suppressed by the 5-lipoxygenase inhibitor zileuton and leukotriene B 4 -receptor antagonist ONO-4057, but not by the cysteinyl leukotriene-receptor antagonist montelukast. The continuous scratching behavior was suppressed by pretreatment with the non-selective muscarinic acetylcholine-receptor antagonist atropine and M 3 muscarinic acetylcholine-receptor antagonist darifenacin. These results suggest that leukotriene B 4 receptor and M 3 muscarinic acetylcholine receptor are involved in the itch-associated response induced by repeated application of oxazolone in mice.

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Section: Discussionmentioning

confidence: 98%

Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice

2010

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“…In mice, cyproheptadine, a serotonin and histamine antagonist, inhibits the itch-related response to serotonin, but does not inhibit the response to mosquito allergy (5,6). Acute topical application of tacrolimus inhibits itch-related responses to mosquito allergy and proteinase-activated receptor-2 (PAR 2 ) agonist, but does not inhibit the responses to serotonin and histamine (7).…”

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confidence: 99%

Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice

et al. 2011

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Itch is a common complaint among patients with cutaneous diseases. H 1 histamine receptor antagonists are the drugs of choice for the treatment of itch, but their effect in ameliorating many pruritic diseases including atopic dermatitis is often unsatisfactory. The reason for this may be due in part to the presence of many itch mediators other than histamine (1), and therefore specific antagonists and inhibitors may not effectively relieve many kinds of pruritic diseases. Although at least two subpopulations of primary afferents (histamine sensitive and insensitive) are involved in itch signaling (2), the types of neurotransmitters involved in itch signaling in the dorsal horn may be far fewer than those of itch mediators in the skin. It was recently reported that gastrin-releasing peptide plays an important role in itch signaling from sensory neurons to the interneurons in the dorsal horn (3). Ablation of dorsal horn neurons expressing gastrin-releasing peptide receptor has been shown to result in the suppression of itch-related responses to histamine and several other itch mediators (3). This raises the possibility that administration of antipruritic agents that act on the dorsal horn will be effective for the treatment of itch of many pruritic diseases.We have recently found that clonidine suppresses the itch-related response of mice to an intradermal injection of serotonin through its action on the α 2 -adrenoceptors in the spinal cord (4). In mice, cyproheptadine, a serotonin and histamine antagonist, inhibits the itch-related response to serotonin, but does not inhibit the response to mosquito allergy (5, 6). Acute topical application of tacrolimus inhibits itch-related responses to mosquito allergy and proteinase-activated receptor-2 (PAR 2 ) agonist, but does not inhibit the responses to serotonin and histamine (7). Itch signals induced by mosquito allergy may be mediated by primary afferents expressing PAR 2 receptors (8). These findings taken together suggest that itch signals of mosquito allergy and serotonin are mediated by separate primary afferents. Therefore, in order to determine whether the stimulation of α 2 -adrenoceptor in the spinal cord would suppress itch induced by different causes, we investigated whether intrathecal clonidine would suppress the itch-related response to mosquito allergy. The descending noradrenergic system exerts tonic inhibition on pain transmission in the dorsal horn mediated by α-adrenoceptors (9, 10). Thus, we also investigated whether the descending monoaminergic systems exert a tonic inhibition on the transmission of itch signals in the spinal cord.Male ICR mice (6 -12-weeks-old; Japan SLC, Shizuoka) were used. They were kept in a room under controlled temperature (22 ± 1°C), humidity (55 ± 10%), and light (light on 7:00 -19:00 h). Food and water were Toyama 930-0194, Japan Received November 29, 2010; Accepted December 30, 2010 Abstract. We investigated whether the descending noradrenergic system regulates allergic itch. Mosquito allergy of the hind paw elici...

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“…Scratching induced by mosquito allergy is suppressed by a 5-lipoxygenase inhibitor and a 5-lipoxygenase activating peptide inhibitor, suggesting the involvement of 5-lipoxygenase metabolites in itch of mosquito allergy (15). Mosquito allergy-induced scratching is not inhibited by a leukotriene B 4 antagonist and cysteinyl leukotriene antagonists (15), but it is suppressed by an antagonist to lipoxin A 4 , a 5-lipoxygenase metabolite (30).…”

Section: Discussionmentioning

confidence: 99%

“…Mosquito allergy-induced scratching is not inhibited by a leukotriene B 4 antagonist and cysteinyl leukotriene antagonists (15), but it is suppressed by an antagonist to lipoxin A 4 , a 5-lipoxygenase metabolite (30). Although an intradermal injection of lipoxin A 4 does not elicit scratching in naive mice, it induces scratching in sensitized mice and also mice given adoptive transfer of CD4 + cells from the skin of sensitized ones (30).…”

Section: Discussionmentioning

confidence: 99%

“…Although the non-sedative H 1 histamine-receptor antagonist terfenadine suppresses plasma extravasation, it does not inhibit scratching responses to mosquito bites and ESGM injection in sensitized mice (13,14). The allergic itch response has been suggested to be mediated by 5-lipoxygenase metabolites (15). In the present experiments, we investigated the efficacy of G. lucidum extract against allergic itch by using a mouse model of mosquito allergy.…”

Section: Inhibitory Effects Of the Methanol Extract Of Ganoderma Lucimentioning

confidence: 93%

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Inhibitory Effects of the Methanol Extract of Ganoderma lucidum on Mosquito Allergy–Induced Itch-Associated Responses in Mice

et al. 2010

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Abstract. Recently, we showed that a methanol extract of Ganoderma lucidum inhibits scratching, an itch-related response, induced by intradermal injections of some pruritogens in mice. The present study investigated whether G. lucidum extract would inhibit allergic itch. In mice sensitized with an extract of salivary gland of mosquito (ESGM), an intradermal injection of ESGM elicited scratching, which was suppressed by oral administration of G. lucidum extract (100 and 300 mg/kg). The scratching was inhibited by the H 1 histamine-receptor antagonist azelastine, but not by the peripherally acting H 1 -antagonist terfenadine, at the oral dose of 30 mg/kg. In sensitized mice, ESGM increased the activity of cutaneous nerve, which was suppressed by G. lucidum extract (300 mg/kg). Although terfenadine (30 mg/kg) inhibited plasma extravasation induced by ESGM in the sensitized mice, G. lucidum extract (300 mg/kg) was without effect. These results suggest that G. lucidum extract relieves allergic itch through a peripheral action. The results support the idea that mast cells and H 1 histamine receptors are not the primary sites of the antipruritic action of G. lucidum extract.

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Possible Involvement of 5-Lipoxygenase Metabolite in Itch-Associated Response of Mosquito Allergy in Mice

Cited by 19 publications

References 35 publications

Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice

Pharmacological Characterization of Itch-Associated Response Induced by Repeated Application of Oxazolone in Mice

Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice

Inhibitory Effects of the Methanol Extract of Ganoderma lucidum on Mosquito Allergy–Induced Itch-Associated Responses in Mice

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