Possible Involvement of Beta-Adrenergic Receptors on Nociceptin/Orphanin FQ Induced Food Consumption in Male Rats

Abstract

Background: The nociceptin/orphanin FQ (N/OFQ) peptide is the endogenous ligand for the N/OFQ peptide (NOP) receptor. Beta adrenergic receptors and N/OFQ are involved in the regulation of food intake through central and peripheral mechanisms.

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“…It is also known that glucagon and glucagon-like peptide (GLP-1) inhibit the food intake (reviewed in (Woods et al, 2006)). In this context, 1 and 2-adrenergic receptors were first shown to inhibit food intake based on -adrenergic blockers and agonists studies in rats (Borsini et al, 1982;Hajinezhad and Shohreh, 2016;Racotta and Soto-Mora, 1993). Moreover, it was shown that the 3-adrenergic receptor is involved in the regulation of food intake reduction (Kanzler et al, 2011).…”