Possible Involvement of Caspases in Proliferation of Neocortical Neural Stem/Progenitor Cells in the Developing Mouse Brain

Yoneyama, Mitsutoshi; Shiba, Tatsuo; Yamaguchi, Taro; Ogita, Kiyokazu

doi:10.1248/bpb.b14-00443

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…They might survive either because they are particularly resistant to caspase activity and apoptosis, as is postulated for stem/progenitor cells generally. Alternatively caspases may actually promote their proliferation or maintenance as has been described for some mammalian progenitors ( Li et al, 2010 ; Yoneyama et al, 2014 ); or some progenitor cells may undergo anastasis and recover from the brink of apoptotic cell death. Although we cannot currently distinguish definitively between these possibilities, the observation that a subset of progenitor cells activates CasExpress might indicate that some cells resist the apoptotic stimulus prior to activation of caspase-3 whereas others experience caspase activity and recover from it.…”

Section: Resultsmentioning

confidence: 96%

CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

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et al. 2016

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Caspase-3 carries out the executioner phase of apoptosis, however under special circumstances, cells can survive its activity. To document systematically where and when cells survive caspase-3 activation in vivo, we designed a system, CasExpress, which drives fluorescent protein expression, transiently or permanently, in cells that survive caspase-3 activation in Drosophila. We discovered widespread survival of caspase-3 activity. Distinct spatial and temporal patterns emerged in different tissues. Some cells activated caspase-3 during their normal development in every cell and in every animal without evidence of apoptosis. In other tissues, such as the brain, expression was sporadic both temporally and spatially and overlapped with periods of apoptosis. In adults, reporter expression was evident in a large fraction of cells in most tissues of every animal; however the precise patterns varied. Inhibition of caspase activity in wing discs reduced wing size demonstrating functional significance. The implications of these patterns are discussed.DOI: http://dx.doi.org/10.7554/eLife.10936.001

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Section: Resultsmentioning

confidence: 96%

CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

Ding

Sun

Argaw

et al. 2016

eLife

111

106

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“…Shukla et al ( 41 ) observed that apigenin promoted the interaction between Ku70 and Bcl-2-associated X, and induced prostate cancer cell apoptosis via apoptosis protein suppression. Caspases are involved in cell proliferation, migration, cytoskeletal organization and immunological effects ( 42 , 43 ). Disorders of the activity of caspases have been associated with multiple pathological processes, including cancer ( 44 ).…”

Section: Discussionmentioning

confidence: 99%

Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines

et al. 2018

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It is widely accepted that apoptosis is closely associated with cancer cell death. However, whether autophagy induces tumor cell death has not been fully elucidated. Various studies have discussed the antitumor properties of rottlerin in human malignancies. The current study aimed to investigate the effects of rottlerin, a natural product isolated from the kamala tree (Mallotus philipensis), on growth inhibition and autophagy in gastric cancer (GC) cell lines in vitro. The results of the present study demonstrated that rottlerin suppressed cell growth, induced autophagy and apoptosis, and reduced migration and invasion in the SGC-7901 and MGC-803 GC cell lines. Furthermore, rottlerin led to microtubule-associated protein 1 light chain 3β-II augmentation and the enrichment of autophagosomes. In addition, the protein expression levels of mechanistic target of rapamycin kinase and S-phase kinase-associated protein 2 were downregulated in GC cells following rottlerin treatment, which is associated with autophagy. The protein levels of caspase-3, cleaved-caspase-3, total poly (ADP-ribose) polymerase (PARP) and cleaved-PARP exhibited no marked alterations in the GC cells following rottlerin treatment, indicating that caspases were likely not involved in rottlerin-induced GC apoptosis. In summary, the results of the present study indicate that rottlerin may inhibit invasion and promote apoptosis in GC cells, which may be mediated by the activation of autophagy. Therefore, rottlerin may be of value in the treatment of GC.

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Possible Involvement of Caspases in Proliferation of Neocortical Neural Stem/Progenitor Cells in the Developing Mouse Brain

Cited by 2 publications

References 13 publications

CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

CasExpress reveals widespread and diverse patterns of cell survival of caspase-3 activation during development in vivo

Rottlerin promotes autophagy and apoptosis in gastric cancer cell lines

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