Possible involvement of regulatory T cell abnormalities and variational usage of TCR repertoire in children with autoimmune neutropenia

Abstract

Patients with autoimmune neutropenia (AIN) showed variational and skewed usages of T cell receptor (TCR)‐Vβ families in CD4+CD25− T cells and CD4+CD25+CD127low T cells, compared to those of control subjects.

Autoimmune Neutropenias: Update on Clinical and Biological Features in Children and Adults

“…52 Likewise, it is unknown if there are recognition signals of neutrophil subpopulations for interaction with cytotoxic T-lymphocytes, NK cells, monocyte/macrophages, MDSC, and other cells that are involved in elimination or cross-talks with neutrophils. 15,17,39,45,53,54…”

“…52 Likewise, it is unknown if there are recognition signals of neutrophil subpopulations for interaction with cytotoxic T-lymphocytes, NK cells, monocyte/macrophages, MDSC, and other cells that are involved in elimination or cross-talks with neutrophils. 15,17,39,45,53,54 Other possible mechanisms for AINP Cellular immune mechanism, implicating clonal or oligoclonal expansions of T-cell and NK-cell populations, may also account for NP particularly in adults.…”

“…For example, it is unknown if certain subpopulations of neutrophils are specific targets of immune mechanisms, for example, those expressing CD177 or those interacting with structures on endothelial cells significant for transmigration to the tissues or from the tissues back to PB or BM, and those interacting with organ‐specific epitopes 52 . Likewise, it is unknown if there are recognition signals of neutrophil subpopulations for interaction with cytotoxic T‐lymphocytes, NK cells, monocyte/macrophages, MDSC, and other cells that are involved in elimination or cross‐talks with neutrophils 15,17,39,45,53,54 …”

Epistemological Assumption: Understanding Protein Polysaccharide Complexes in Improving Diabetes Treatment

“…Recently, it has been mentioned that a new therapy of utilization regulatory T cells is used in those patients who have Type-1 diabetes for protecting the insulin-producing cells of the pancreas (Goda et al, 2021). The beta-cell autoantigens are glutamic acid decarboxylase, insulin, insulinoma antigen, and tyrosine phosphatase (Maurizi et al, 2018).…”

Primary autoimmune neutropenia in early childhood - Genetic variations and antibody specificity

“…In Study IV, the paper, "Genetic polymorphisms in IL-2, IL-10 and FOXP3 are associated with autoimmune neutropenia in early childhood and autoantibody specificity in a Danish cohort" focused on an observation that had shown low frequencies of total and activated Tregs and skewness of TCR-Vβ families among AIN patients [194], [195]. A decrease in the number of activated Tregs may play an important role in the autoimmune response to HNA due to a deficiency of suppressive function.…”