Possible Involvement of the Serotonergic System in Intraseptal Opioid‐Induced Hypothermia in Ground Squirrels^a

Altered thermoregulation in ambulatory schizophrenia patients: A naturalistic study

“…We currently do not know the exact mechanism underlying such dysfunctional thermoregulation. It could be mediated by various neurotransmitter systems, among them those associated with the pathophysiology of schizophrenia (e.g., dopamine, serotonin, norepinephrine) (Snyder 1977(Snyder , 1981(Snyder , 1982(Snyder , 1988Bligh 1979;Clark 1979;Lindvall et al 1983;Liu et al 1995;Cui et al 1997;Kolka and Stephenson 1997;Scarpace 1997;Schmid et al 1997;Catalina et al 2002;Crandall et al 2002). Such altered neurotransmission can act either directly on central thermoregulatory effectors (i.e.…”

Corneal temperature in schizophrenia patients

“…The hypothalamus, and particularly its anterior pre-optic area receives afferent inputs from cold-or warm-sensitive neurons and subsequently stimulates warm effectors (heat-producing mechanisms) or cold effectors (heat-dissipating mechanisms, mainly sweating) to maintain core body temperature of y37 xC (Satinoff, 1978 ;Silver et al, 1991). Most data imply that dopaminergic transmission is essential for proper thermoregulation in humans (Bligh, 1979 ;Clark, 1979 ;Crandall et al, 2002 ;Lindvall et al, 1983), although other neurotransmitter systems and/or substances have also been shown to participate in core temperature regulation (Catalina et al, 2002 ;Cui et al, 1997 ;Kolka and Stephenson, 1997 ;Liu et al, 1995 ;Scarpace, 1997 ;Schmid et al, 1997). Altered central dopaminergic transmission is also widely accepted as one of the factors involved in the pathophysiology of schizophrenia (Carlsson and Lindquist, 1963 ;Kapur and Remington, 1996) and thus, hypothetically, schizophrenia patients might be at increased risk of developing thermoregulatory dysregulation.…”