Possible link between stress-related factors and altered body composition in women with polycystic ovarian syndrome

Basu, Barnali Ray; Chowdhury, Olivia; Saha, Sudip

doi:10.4103/jhrs.jhrs_78_17

Cited by 50 publications

(55 citation statements)

References 35 publications

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“…One study investigated body fat distribution using the metric of waist‐to‐hip ratio (WHR) in relation to salivary cortisol. Compared to low WHR subjects, high WHR subjects secreted significantly more cortisol during stressful sessions after 60 minutes of stress …”

Section: Discussionmentioning

confidence: 84%

“…Compared to low WHR subjects, high WHR subjects secreted significantly more cortisol during stressful sessions after 60 minutes of stress. 27,39 Initially, as insulin levels increase, biologically active testosterone also increases. This is thought to be due to the decreasing production of sex hormone-binding globulin levels.…”

Section: Ta B L E 1 Baseline Characteristics For Each Study Included mentioning

confidence: 99%

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Eating, sleeping and sexual function disorders in women with polycystic ovary syndrome (PCOS): A systematic review and meta‐analysis

Thannickal

Brutocao

Alsawas

et al. 2020

Clinical Endocrinology

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Purpose We aim to evaluate the association of PCOS with eating, sleeping and sexual function disorders. Methods A comprehensive search including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus through 01 August 2018 was conducted for studies reporting the prevalence of any eating, sleep or sexual function disorders in patients with PCOS. Independent reviewers selected studies and extracted data. A random‐effects model was utilized to generate pooled odds ratio (OR) and 95% confidence intervals (CI) for binary outcomes, and mean difference (MD) and 95% CI for continuous outcomes. Results We included 36 studies reporting on 349,529 patients. Compared to women without PCOS, women with PCOS were more likely to have bulimia nervosa (OR 1.37; %CI, 1.17 to 1.60), binge eating (OR 2.95; 95%CI, 1.61 to 5.42), or any eating disorder (OR 1.96; 95% CI 1.18 to 3.24); but not anorexia nervosa (OR 0.92; 95%CI, 0.78 to 1.10). Women with PCOS were more likely to have sleep disorders like hypersomnia (OR 4.39; %CI, 1.07 to 18.07) and obstructive sleep apnoea (OR 10.81; %CI, 2.39 to 48.83). Women with PCOS had lower sexual satisfaction as measured on a visual analogue scale (MD −29.67; 95% CI, −36.97 to −22.37), but no difference in Total Female Sexual Function Index (MD −0.06; 95% CI, −0.51 to 0.38). Conclusion PCOS can be associated with an increased risk of eating and sleeping disorders as well as decreased sexual satisfaction. Screening for these disorders in women with PCOS may allow early intervention and improve quality of life.

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Section: Discussionmentioning

confidence: 84%

Section: Ta B L E 1 Baseline Characteristics For Each Study Included mentioning

confidence: 99%

Eating, sleeping and sexual function disorders in women with polycystic ovary syndrome (PCOS): A systematic review and meta‐analysis

Thannickal

Brutocao

Alsawas

et al. 2020

Clinical Endocrinology

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“…The assay employed 2-chloro-4-nitrophenol (chromogenic substrate), linked to maltotriose (CNP-Gal-G2). A-A catalyses the hydrolysis of CNP-Gal-G2 to CNP and the hydrolysis rate was measured as an enhancement in absorbance due to the formation of CNP that is proportional to the A-A activity in the sample (Direct Substrate Method, Kinetic Enzymatic, Crest Biosystem, Goa, India) [4].…”

Section: Assay Of Saamentioning

confidence: 99%

“…The best t curve was obtained by plotting the mean value of the absorbance of the calibrators against concentration. The values of absorbance of samples were interpolated on the calibration curve for obtaining the corresponding values of the concentrations presented in ng/ml [4].…”

Section: Assay Of Salivary Cortisolmentioning

confidence: 99%

Evaluation of Association of Anthropometric Indices With Stress Response in Pcos Population

Basu

Chakrabarty

Saha

et al. 2020

ijsr

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Background: Polycystic ovary syndrome (PCOS) is a complex endocrinopathy of women in their reproductive age with diversity in clinical manifestations. The phenotypic expressions and altered anthropometric indices are the key indicators of the abnormal transformations in metabolic, endocrine, and reproductive functionality of PCOS. Stress-induced activation of the Sympathetic-Adrenal-Medullary (SAM)-system and Hypothalamic-Pituitary-Adrenal (HPA)-axis results in series of neuroendocrine adaptations where over-activation of SAM/HPA response negatively affects the Hypothalamic-Pituitary-Gonadal (HPG) axis that highlight the possibility of the adverse impact of stress response system on reproductive and metabolic functions. Psychological distress and anxiety induced by the COVID-19 pandemic may aggravate the expressivity of PCOS and associated complexities. Objective: The present study aimed to find out some phenotypic features (hirsutism, acne, Acanthosis Nigricans (AN) and alopecia) in association with deviated anthropometric and derived indices, and stress biomarkers (Salivary α-amylase (SAA) and cortisol of SAM and HPA-axis respectively) among PCOS patients. Statistical analysis: SPSS (IBM, version 20) and Microsoft Office Excel 2010 were implied, and the quantitative variables were described as mean±SD (P < 0.01 and P < 0.05). Results: Significant alternations in the anthropometric indices were observed for PCOS patients that may lead to health risk. Alteration in body composition was strongly correlated with stress biomarkers in the case of both the experimental and control group. Central obesity was found to be a significant indicator of altered body composition in response to stress. Conclusion: Stress is a key modulator in the alternation of phenotypic manifestation as well as body composition of PCOS patients which could be the plausible reason for further deterioration of this multifaceted disorder due to the COVID-19 pandemic.

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“…A striking correlation exists between stress and progression of PCOS [15]. Urocortin (Ucn) belongs to the corticotrophin-releasing factor (CRF) family of peptides consisting of 41 amino acids [16], which are involved in many of the endocrine responses towards stress.…”

Section: Introductionmentioning

confidence: 99%

Effect of DHT-Induced Hyperandrogenism on the Pro-Inflammatory Cytokines in a Rat Model of Polycystic Ovary Morphology

et al. 2020

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Background and Objectives: Polycystic ovary syndrome (PCOS) is one of the most prevalent disorders among women of reproductive age. It is considered as a pro-inflammatory state with chronic low-grade inflammation, one of the key factors contributing to the pathogenesis of this disorder. Polycystic ovary is a well-established criterion for PCOS. The present investigation aimed at finding the role of hyperandrogenism, the most important feature of PCOS, in the development of this inflammatory state. To address this problem, we adopted a model system that developed polycystic ovary morphology (PCOM), which could be most effectively used in order to study the role of non-aromatizable androgen in inflammation in PCOS. Materials and Methods: Six rats were used to induce PCOM in 21-days-old female Wistar albino rats by using a pre-determined release of dihydrotestosterone (DHT), a potent non-aromatizable androgen, achieved by implanting a DHT osmotic pump, which is designed to release a daily dose of 83 μg. Results: After 90 days, the rats displayed irregular estrous cycles and multiple ovarian cysts similar to human PCOS. Elevated serum inflammatory markers such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and the presence of a necrotic lesion in the liver, osteoclast in the femur, multinucleated giant cells and lymphocytes in the ovary based on histopathological observation of DHT-treated rats clearly indicated the onset of inflammation in the hyperandrogenic state. Our results show no significant alterations in serum hormones such as luteinizing hormone (LH), follicle stimulating hormone (FSH), insulin, and cortisol between control and hyperandrogenised rats. DHT was significantly elevated as compared to control. mRNA studies showed an increased expression level of TNF-α and IL-1β, further, the mRNA expression of urocortin 1 (Ucn-1) was stupendously elevated in the liver of hyperandrogenised rats. Conclusions: Thus, results from this study provide: (1) a good PCOM model system in order to study the inflammatory changes in PCOS aspects, (2) alteration of inflammatory markers in PCOM rats that could be either due to its direct effect or by the regulation of various inflammatory genes and markers in the liver of hyperandrogenic state suggesting the regulatory role of DHT, and (3) alteration in stress-related protein in the liver of PCOM rats.

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Possible link between stress-related factors and altered body composition in women with polycystic ovarian syndrome

Cited by 50 publications

References 35 publications

Eating, sleeping and sexual function disorders in women with polycystic ovary syndrome (PCOS): A systematic review and meta‐analysis

Eating, sleeping and sexual function disorders in women with polycystic ovary syndrome (PCOS): A systematic review and meta‐analysis

Evaluation of Association of Anthropometric Indices With Stress Response in Pcos Population

Effect of DHT-Induced Hyperandrogenism on the Pro-Inflammatory Cytokines in a Rat Model of Polycystic Ovary Morphology

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