Possible mechanism by which zinc protects the testicular function of rats exposed to cigarette smoke

Sankako, Michele Kimie; Garcia, Patrícia Carvalho; Piffer, Renata C.; Dallaqua, Bruna; Damasceno, Débora Cristina; Pereira, Olga

doi:10.1016/s1734-1140(12)70951-9

Cited by 25 publications

(16 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Sankako et al . [3], Zn works as an aromatase blocker; therefore, the conversion of testosterone into estrogen is inhibited. This was confirmed in the level of testosterone between treatments compared to control after 50 days of shell administration, which was significantly different (p<0.05).…”

Section: Resultsmentioning

confidence: 99%

“…Besides the reduction of testosterone level, Zn deficiency is associated with impaired spermatogenesis due to the elevation of oxidative stressor and apoptosis. Zn is capable of increasing testosterone through aromatase inhibition mechanism by blocking the conversion of testosterone to estradiol [3]. Letrozole, an aromatase blocker, can increase testosterone both in rats and old rooster in different pathways.…”

Section: Discussionmentioning

confidence: 99%

“…Sankako et al . [3] reported that testosterone level will increase if aromatase enzyme is blocked since the conversion of testosterone to estrogen is inhibited. Salehi et al .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of shell as natural testosterone boosters in Sprague Dawley rats

et al. 2019

View full text Add to dashboard Cite

Aim:This study aimed to evaluate the effect of shell supplementation on the regulation of male reproduction in ratsMaterials and Methods:The zinc (Zn) level of shell from blood clam (Anadara granosa), green mussel (Perna viridis), and conch shell (Telescopium telescopium) was analyzed. The highest Zn content shell was fed to male Sprague Dawley rats for 0, 9, 30, and 50 days at the dose of either 0.09 mg/200 g BW or 0.18 mg/200 g BW. To determine the testosterone levels, blood was collected through the infraorbitalis sinus just before the rat was sacrificed. Testicular and brain were also collected for Cyp19 aromatase receptor analysis.Results:The Zn level in the shell of blood clam, green mussel, and conch shell 61.55 mg/kg, 2.78 mg/kg, and 3.93 mg/kg, respectively. The testosterone level of T1 group receiving 0.18 mg/200 g BW for 0, 9, 30, and 50 days was 1.42±0.59, 2.15±1.58, 2.98±2.53, and 8.11±2.03 ng/mL, respectively. The testosterone level of T2 group receiving 0.09 mg/200 g BW for 0, 9, 30, and 50 days was 2.50±0.32, 1.25±0.60, 3.87±3.27, and 3.54±0.23 ng/mL, respectively. The T3 group receiving Na-CMC showed the level of testosterone at days 0, 9, 30, and 50 days was 0.77±0.22, 1.99±1.65, 4.12±0.07, and 2.19±1.30 ng/mL, respectively. Finally, the T4 group receiving Zn showed testosterone levels at days 0, 9, 30, and 50 days was 0.51±0.58, 2.24±3.16, 4.58±1.97, and 2.89±0.20 ng/mL, respectively. There was a significant difference (p<0.05) between the T1 group compared to the other groups. However, the absence of expression of Cyp19 aromatase both in Leydig cells and the brain indicated no conversion of testosterone to estradiol. To add, this finding showed the potential use of the shell to boost the testosterone level in male rats.Conclusion:Shell acted as an aromatase blocker to boost the testosterone level in male rats. This also indicates its promising application in birds to manipulate the quality of song and feather.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of shell as natural testosterone boosters in Sprague Dawley rats

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Scavenging/chelation of free radicals and transition metals have been reported as some of the mechanisms by which antioxidant compounds could protect the cells/biomolecules from radical/metal induced oxidative damage (Valko et al, 2005;Flora, 2009;Kedare and Singh, 2011;Khan and Awan, 2014 scavenging assay methods are based on spectrophotometry and are commonly used to determine the antioxidative ability of natural extracts based on their ability to scavenge/reduce the radical cation (Re et al, 1999;Kedare and Singh, 2011;Skotti et al, 2014). Several reports have revealed that excessive production of free radicals or ROS is one of the causes of male infertility which could be due to their deleterious effect on testes integrity/function (Aitken and Roman, 2008;Sankako et al, 2012;Agarwal et al, 2014). From our results, the assay on DPPH and ABTS radical scavenging abilities revealed that the extract could scavenge radicals.…”

Section: Discussionmentioning

confidence: 99%

Phenolic Composition and Inhibitory Ability of Methanolic Extract from Pumpkin (Cucurbita pepo L) Seeds on Fe-induced Thiobarbituric acid reactive species in Albino Rat's Testicular Tissue In-Vitro

Akomolafe¹,

Oboh²,

Oyeleye³

et al. 2016

J App Pharm Sci

View full text Add to dashboard Cite

Pumpkin seed has been associated with myriad of medicinal uses in different part of the world. In this study, phenolic composition and Fe 2+ induced thiobarbituric acid reactive species (TBARS) inhibitory ability of methanolic extract from pumpkin seeds in rat's testes homogenates were determined. The extract was prepared with 80% methanol (v/v) and the radicals [(1,1-diphenyl-2 picrylhydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS)] scavenging, Fe 2+ chelation and ferric reducing abilities of the extract were carried out. The phenolics composition was also investigated using gas chromatography couple with flame ionization detector (GC-FID). The GC analysis revealed the presence of vallinic, coumaric protocatechuic, caffeic, ferulic and sinapinic acids, and apigenin, quercetin, luteolin, kaempferol as the dominant phenolic compounds. The results revealed that the extract inhibited Fe 2+ -induced TBARS, scavenge DPPH radical and chelate Fe 2+ in a dose dependent manner. The extract also scavenged ABTS radical and reduced Fe 2+ to Fe 3+ . Although, the standard used had higher effect compared to the extract, nevertheless, the TBARs inhibitory potential of the extracts clearly gives an insight on the protective potentials against oxidative induce testicular damage that might lead to male infertility if unchecked. These abilities could however be linked to the presence of polyphenolic compounds.

show abstract

“…The effect of zinc supplementation in raising testosterone levels in various animals has also been demonstrated in more studies [64,65]. Interestingly, some studies reported the effect of zinc in increasing testosterone levels and protecting Leydig cell from damage [66][67][68].…”

Section: Zincmentioning

confidence: 85%

A Review of foods and food supplements increasing testosterone levels

Kataoka¹,

Hotta²,

Kimura³

2021

JOMH

View full text Add to dashboard Cite

Androgens are essential for male physical activity. Age-related androgen deﬁciency, known as late-onset hypogonadism (LOH), is considered a risk factor for several diseases. There are many men's health supplements on the market. Therefore, the purpose of this review is to summarize the food ingredients that have been suggested in published literature to increase testosterone levels. A review of previously reported animal studies suggested that 5 representative nutritional components, 7 food ingredients, and 25 supplements were associated with testosterone. Some food and supplements inﬂuence testosterone levels in various animals by directly increasing testosterone or suppressing the decrease in testosterone production due to testicular toxicity. There are three mechanisms by which foods or supplements increase testosterone production: 1) regulating luteinizing hormone, the hormone that stimulates testosterone production, 2) regulating testosterone synthase in the testis, and 3) regulating testosterone-degrading enzymes. In contrast, suppressing the decrease in testosterone depends on the antioxidant effect of the foods. Although detailed mechanistic studies and clinical trials are required to validate these ﬁndings, the use of food to regulate testosterone levels is a promising therapeutic option.

show abstract

Possible mechanism by which zinc protects the testicular function of rats exposed to cigarette smoke

Abstract: 84Analgesia and serum assays of controlled-release

Cited by 25 publications

References 50 publications

Effect of shell as natural testosterone boosters in Sprague Dawley rats

Effect of shell as natural testosterone boosters in Sprague Dawley rats

Phenolic Composition and Inhibitory Ability of Methanolic Extract from Pumpkin (Cucurbita pepo L) Seeds on Fe-induced Thiobarbituric acid reactive species in Albino Rat's Testicular Tissue In-Vitro

A Review of foods and food supplements increasing testosterone levels

Contact Info

Product

Resources

About