Possible mechanism for the influence of weak magnetic fields on biological systems

Lednev, V. V.

doi:10.1002/bem.2250120202

Cited by 525 publications

(296 citation statements)

References 10 publications

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“…Considering EM interactions from a purely physical point of view, several mechanisms have been proposed to account for the initial interactions with cells (Liboff et al, 1987;Lednev, 1991;Blanchard and Blackman, 1994), but these models have been limited by their inability to account for the wide range of experimental observations. The Mobile Charge Interaction (MCI) model (Blank, 1995a), based on simple physical interactions, grew out of a wide range of experiments.…”

mentioning

confidence: 99%

Insights into electromagnetic interaction mechanisms

Goodman

Blank

2002

Journal Cellular Physiology

166

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Low frequency (< 300 Hz) electromagnetic (EM) fields induce biological changes that include effects ranging from increased enzyme reaction rates to increased transcript levels for specific genes. The induction of stress gene HSP70 expression by exposure to EM fields provides insight into how EM fields interact with cells and tissues. Insights into the mechanism(s) are also provided by examination of the interaction of EM fields with moving charges and their influence on enzyme reaction rates in cell-free systems. Biological studies with in vitro model systems have focused, in general, on the nature of the signal transduction pathways involved in response to EM fields. It is likely, however, that EM fields also interact directly with electrons in DNA to stimulate biosynthesis. Identification of an EM field-sensitive DNA sequence in the heat shock 70 (HSP70) promoter, points to the application of EM fields in two biomedical applications: cytoprotection and gene therapy. EM field induction of the stress protein hsp70 may also provide a useful biomarker for establishing a science-based safety standard for the design of cell phones and their transmission towers.

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confidence: 99%

Insights into electromagnetic interaction mechanisms

Goodman

Blank

2002

Journal Cellular Physiology

166

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“…More hydroxyl (OH -) ions are created to form alkaline molecules, and reduce acidity, for this reason cancer cells do not survive well in an alkaline environment. 45 Some animal studies have concluded that the magnetization of water increased the permeability through cell membranes, 46 and that the magnetic field directly affected intracellular fluid and intracellular substances to activate enzymes inside the cells and to accelerate biochemical reactions in the body. 47 Previous studies with magnetized water, reported that the long-term intake of magnetized water (over 8 weeks) may be beneficial in both prevention and treatment of complications in diabetic, treatment effect of magnetized water not only decreased the blood glucose and glycated hemoglobin levels but also reduced blood and liver DNA damages in STZ-induced diabetic rats.…”

Section: Resultsmentioning

confidence: 99%

Investigation of role magnetized water used in supplementary feeding for honeybees to modulate the genotoxic side effects induced by cyclophosphamide in mice bone marrow cells

Farhan¹,

Chechan

Alkinani

2017

J. contemp. med. sci.

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Objective To evaluate the possible protective role of honey formed through innovative way by using magnetized water instead of tab water in supplementary feeding for bees (HW) and compared with two honey types formed by two different feeding solutions; sugar syrup (HS) and nectar of flowers (HF) against cyclophosphamide (CP) genotoxicity in mice bone marrow cells, by using the micronucleus assay (MN). Methods Mice were divided into 8 groups from 3 animals each. G1 as control. G2 were exposed to CP (40 mg/kg), G3, G4, and G5 received two dose of three types of honey at doses (300, 600 mg/kg) respectively. The other groups G6, G7 and G8 were supplemented with three types honey (300 mg/kg) in three different experimental protocols, as pre 2 h, post 2 h, and concomitant treatment for 7 and 14 days. Results Examination and analysis of MN showed no mutagenic effect of three types honey per se doses, especially in low dose (300 mg/kg). Meanwhile, CP induced a significant (P < 0.01) increase in MN frequency. While dual treatment with groups of honey HW caused a significant reduction in MN induced by CP in bone marrow cells in a time-dependant manner. Also, the results confirmed the protective efficacy of HW group and/or HF group as compared with HS group, against CP-toxicity. Conclusion Our study suggests using magnetized water in supplementary feeding of bee, that could give the honey protective effect against genotoxicity induced by CP, it is also fosters antioxidant activity of honey constituents. Therefore, honey HW can be used as an adjuvant with chemotherapeutic agents for minimizing the genotoxic side effects of the anticancer drug CP.

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“…It is pertinent to infer that exposure to magnetic fields induces quite a variety of biological effects. Different waveform magnetic field sources results in varied biological effects on living systems, as their frequency spectrums are diverse [39,58,59]. …”

Section: Discussionmentioning

confidence: 99%

Viability of unstimulated lymphocytes exposed to extremely low frequency electromagnetic fields is dependent on intensity

Rajendra¹,

Sujatha²,

Sashidhar³

et al. 2012

Biodiscovery

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The cell viability and DNA damage in unstimulated sheep primary lymphocytes subjected to different extremely low electromagnetic field intensities (5, 50 and 100 µT; 50 Hz) were studied with special emphasis on apoptosis. Sheep primary lymphocytes cultured in RPMI, supplemented with 10% FBS in the absence of mitogens, were exposed till 16 h. The cell viability assessment by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay showed a dose dependent enhancement of viability at 16 h. Further, quantitative DNA laddering and flow cytometric analysis showed a significant decrease in apoptosis of the cells subjected to 100 (p<0.01) and 50 µT (p<0.05) for 16 h as compared to control group. There was a statistically significant decrease (p<0.01) in the specific activity of caspase 9 at 100 µT in cells exposed for 16 h. However, no enhancement of DNA damage was observed at 5, 50 and 100 µT as evidenced by comet assay. Comet assay also confirmed the decreased cell death of exposed cells (100 µT). Experimental data suggests decreased apoptosis at 100 µT (50 Hz), possibly by the suppression of caspase 9 activity leading to the enhanced cell viability. Effect of ELF-EMF on primary lymphocytesBioDiscovery | www.biodiscoveryjournal.co.uk

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Possible mechanism for the influence of weak magnetic fields on biological systems

Cited by 525 publications

References 10 publications

Insights into electromagnetic interaction mechanisms

Insights into electromagnetic interaction mechanisms

Investigation of role magnetized water used in supplementary feeding for honeybees to modulate the genotoxic side effects induced by cyclophosphamide in mice bone marrow cells

Viability of unstimulated lymphocytes exposed to extremely low frequency electromagnetic fields is dependent on intensity

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