Possible mechanism of GATA4 inhibiting myocardin activity during cardiac hypertrophy

Xu, Yao; Chen, Liang; Luo, Ying; Xing, Weibing; Zhang, Tongcun

doi:10.1002/jcb.28178

Cited by 6 publications

(2 citation statements)

References 32 publications

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“…Those post-translational modifica-tions were reported to be crucial for the cardiac hypertrophic function of Gata4. Thus, over the past several years, the molecular mechanisms behind cardiac hypertrophy have been investigated [34,[137][138][139][140]. More evidence for the implication of GATA4 phosphorylation in cardiac diseases was provided in another study [67].…”

Section: Gata4 Possesses Intrinsic Cardiogenic Activitiesmentioning

confidence: 99%

Towards Understanding the Gene-Specific Roles of GATA Factors in Heart Development: Does GATA4 Lead the Way?

Afouda

2022

IJMS

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Transcription factors play crucial roles in the regulation of heart induction, formation, growth and morphogenesis. Zinc finger GATA transcription factors are among the critical regulators of these processes. GATA4, 5 and 6 genes are expressed in a partially overlapping manner in developing hearts, and GATA4 and 6 continue their expression in adult cardiac myocytes. Using different experimental models, GATA4, 5 and 6 were shown to work together not only to ensure specification of cardiac cells but also during subsequent heart development. The complex involvement of these related gene family members in those processes is demonstrated through the redundancy among them and crossregulation of each other. Our recent identification at the genome-wide level of genes specifically regulated by each of the three family members and our earlier discovery that gata4 and gata6 function upstream, while gata5 functions downstream of noncanonical Wnt signalling during cardiac differentiation, clearly demonstrate the functional differences among the cardiogenic GATA factors. Such suspected functional differences are worth exploring more widely. It appears that in the past few years, significant advances have indeed been made in providing a deeper understanding of the mechanisms by which each of these molecules function during heart development. In this review, I will therefore discuss current evidence of the role of individual cardiogenic GATA factors in the process of heart development and emphasize the emerging central role of GATA4.

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Section: Gata4 Possesses Intrinsic Cardiogenic Activitiesmentioning

confidence: 99%

Towards Understanding the Gene-Specific Roles of GATA Factors in Heart Development: Does GATA4 Lead the Way?

Afouda

2022

IJMS

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“…Hypertrophic cardiomyopathy is characterized by left ventricular hypertrophy accompanied by diastolic dysfunction 1 . During myocardial hypertrophy, various hypertrophic responsive genes are directly activated by transcription factors including GATA4, AP-1, Sp1, SRF, TEF-1 and NFAT 2–4 . GATA4 , a member of the GATA transcription factor family, is highly expressed in the heart and activates transcription of hypertrophic responsive genes including α-myosin heavy chain, cardiac troponin C, atrial natriuretic peptide ( ANP ), and brain natriuretic peptide ( BNP ) 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy

et al. 2019

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Kindlin-2 plays an important role in the regulation of cardiac structure and function. Depletion of Kindlin-2 contributes to cardiac hypertrophy and progressive heart failure, however, the precise mechanisms involved in this process remain unclear. GATA4 is a critical transcription factor in regulating cardiogenesis. We found that Kindlin-2 suppresses the expression of GATA4 through binding to its promoter and prevents cardiomyocytes from hypertrophy induced by isoproterenol (ISO) treatment. Mechanistically, Kindlin-2 interacts with histone methyltransferase SUV39H1 and recruits it to GATA4 promoter leading to the occupancy of histone H3K9 di- and tri-methylation. Furthermore, to confirm the function of Kindlin-2 in vivo, we generated mice with targeted deletion of cardiac Kindlin-2. We found that 6-month-old Kindlin-2 cKO mice have developed hypertrophic cardiomyopathy and that this pathological process can be accelerated by ISO-treatment. GATA4 expression was markedly activated in cardiac tissues of Kindlin-2 cKO mice compared to wild-type animals. Collectively, our data revealed that Kindlin-2 suppresses GATA4 expression by triggering histone H3K9 methylation in part and protects heart from pathological hypertrophy.

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Chitinase 3 like-1 activates the Akt pathway, inducing NF-κB-dependent release of pro-inflammatory cytokines and promoting the proliferative ability in nasopharyngeal carcinoma cells

Li,

Fan,

Zhou

2024

Cytokine

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Possible mechanism of GATA4 inhibiting myocardin activity during cardiac hypertrophy

Cited by 6 publications

References 32 publications

Towards Understanding the Gene-Specific Roles of GATA Factors in Heart Development: Does GATA4 Lead the Way?

Towards Understanding the Gene-Specific Roles of GATA Factors in Heart Development: Does GATA4 Lead the Way?

Kindlin-2 suppresses transcription factor GATA4 through interaction with SUV39H1 to attenuate hypertrophy

Chitinase 3 like-1 activates the Akt pathway, inducing NF-κB-dependent release of pro-inflammatory cytokines and promoting the proliferative ability in nasopharyngeal carcinoma cells

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