Possible Mechanisms and Special Clinical Considerations of Curcumin Supplementation in Patients with COVID-19

Heidari, Zinat; Mohammadi, Marzieh; Sahebkar, Amirhossein

doi:10.1007/978-3-030-64872-5_11

Cited by 9 publications

(8 citation statements)

References 88 publications

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“…However, there is a lack of information suggesting that curcumin may have a positive role for treating CVDs in patients with COVID-19. Despite this, some review papers have examined the potential effects of curcumin in the treatment of COVID-19, in particular the value of curcumin supplementation as an anti-inflammatory and antioxidant compound in patients with COVID-19 [ 68 ]. Moreover, the potential of effect of curcumin may include inhibiting the entry of virus to the cells, inhibiting encapsulation of the virus and viral protease, and modulating different cellular signaling pathways, for example curcumin has strong inhibitory effect on nuclear factor-kappa B (NF-κB) [ 68 ].…”

Section: Antioxidant Anti-platelet and Anticoagulant Potential Of Phe...mentioning

confidence: 99%

The Antioxidant, Anti-Platelet and Anti-Coagulant Properties of Phenolic Compounds, Associated with Modulation of Hemostasis and Cardiovascular Disease, and Their Possible Effect on COVID-19

Olas

2022

Nutrients

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Patients affected by coronavirus disease 2019 (COVID-19) demonstrate a range of hemostasis dysfunctions, such as coagulation dysfunction and changes in blood platelet function, this being a major cause of death. These complications may also be associated with oxidative stress. Recently, various papers, including some reviews, have suggested that the use of dietary bioactive compounds, including phenolic compounds, may play a significant role in the treatment of COVID-19. However, while some phenolic compounds, such as curcumin, resveratrol, myricetin and scutellarian, have been found to have antiviral effects against COVID-19, recommendations regarding the use of such compounds to prevent or reduce the risk of CVDs during COVID-19 infection remain tentative. The present mini-review examines the antioxidant, anti-platelet and anticoagulant and antiviral activities of selected phenolic compounds and the possible implications for their use in treating CVDs associated with COVID-19. This review also examines whether these phenolic compounds can be promising agents in the modulation of hemostasis and CVDs during COVID-19. While their properties have been well documented in various in vitro and in vivo studies, particularly their positive role in the prophylaxis and treatment of CVDs, less is known regarding their prophylactic potential against CVDs during COVID-19, and no credible evidence exists for their efficiency in humans or animals. In such cases, no in vitro or in vivo studies are available. Therefore, it cannot be unequivocally stated whether treatment with these phenolic compounds offers benefits against CVDs in patients with COVID-19.

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Section: Antioxidant Anti-platelet and Anticoagulant Potential Of Phe...mentioning

confidence: 99%

The Antioxidant, Anti-Platelet and Anti-Coagulant Properties of Phenolic Compounds, Associated with Modulation of Hemostasis and Cardiovascular Disease, and Their Possible Effect on COVID-19

Olas

2022

Nutrients

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“…Besides the antibacterial properties, it demonstrates antifungal and antiviral activities. The antioxidant and antiinflammatory effects of curcumin may also play a role in this regard (Heidari, Mohammadi, & Sahebkar, 2021; Moghadamtousi et al, 2014; Tyagi, Singh, Kumari, Kumari, & Mukhopadhyay, 2015; Zheng et al, 2020).…”

Section: Resultsmentioning

confidence: 99%

Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence

Heidari

Daei

Boozari

et al. 2021

Phytotherapy Research

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This systematic review was designed to determine the clinical efficacy and safety of curcumin supplementation for pediatric patients based on clinical trials in children.We systematically searched electronic databases including PubMed, EMBASE, Web of Science, and Scopus for all studies that investigated curcumin administration in the pediatric population without any time frame limitation. Finally, we identified 16 studies for this review. Clinical efficacy and safety of curcumin were assessed in children with inflammatory and immune disorders (including asthma, inflammatory bowel disease (IBD), and juvenile idiopathic arthritis (JIA)), metabolic disorders, autosomal dominant polycystic kidney disease (ADPKD), cystic fibrosis (CF), tetralogy of Fallot (TOF), and infectious diseases. Curcumin was administered in a wide range of doses (45 mg-4,000 mg daily) and durations (2-48 weeks). Overall, curcumin was well tolerated in all studies and improved the severity of inflammatory and immune disorders and metabolic diseases. However, more studies are needed to clarify the role of curcumin supplementation among children with ADPKD, CF, TOF, and infectious diseases. Because of substantial heterogeneity in methodological quality, design, outcomes, dose, duration of intake, formulations, and study populations across studies, no quantitative analysis was performed. Additional large-scale, randomized, placebo-controlled clinical trials are needed to confirm the results of the conducted studies.

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“…Three curcuminoids (Curs) such as Cur 1, Cur 2 and Cur 3 in turmeric products are well-known for their antiinflammatory, antioxidant, and immunomodulatory effects, 1) and recently interesting approach of its supplementation for declared coronavirus disease 2019 (COVID-19). [2][3][4] Based on chemical antioxidant properties, it has a wide range of pharmacological preservation for infection, cancer, nerve disease and aging. Thus, directions for future investigations to be undertaken in the chemistry of Curs have been proposed.…”

Section: Introductionmentioning

confidence: 99%

Study on the Synthesis of Methylated Reference and Their Application in the Quantity of Curcuminoids Using Single Reference Liquid Chromatography Based on Relative Molar Sensitivity

Takahashi

Nishizaki²,

Masumoto³

et al. 2022

CHEMICAL & PHARMACEUTICAL BULLETIN

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We report on the recommendation of the simple and versatility of methylated reference (MR) to improve applications in the single reference (SR)-LC based on relative molar sensitivity (RMS). Three curcuminoids (Curs) such as curcumin, demethoxycurcumin and bisdemethoxycurcumin in turmeric products were determined using authentic standards and methylated curcumin. In addition, high-speed countercurrent chromatography (HSCCC) purification is necessary to separate Curs for indicating the RMS. For HSCCC separation, a biphasic solvent system was used to obtain these fractions, which were then subjected to 1 H quantitative NMR to determine their contents in each test solution. Using these solutions, the RMS of Curs are calculated from slopes ratios of calibration curves (three ranges from 0-100 µmol/L, r 2 > 0.998). The averaged RMS of Curs were 8.92 (relative standard deviation (RSD), 1.17%), 8.97 (2.18%), and 9.61 (0.77%), respectively. Cur concentrations in turmeric products can be determined using RMS, peak area, and MR content added in these samples. This proposed method, which is based on chemical methylation and the SR-LC assay has been successfully applied for the simple and reliable estimation of Curs in turmeric products.

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Possible Mechanisms and Special Clinical Considerations of Curcumin Supplementation in Patients with COVID-19

Cited by 9 publications

References 88 publications

The Antioxidant, Anti-Platelet and Anti-Coagulant Properties of Phenolic Compounds, Associated with Modulation of Hemostasis and Cardiovascular Disease, and Their Possible Effect on COVID-19

The Antioxidant, Anti-Platelet and Anti-Coagulant Properties of Phenolic Compounds, Associated with Modulation of Hemostasis and Cardiovascular Disease, and Their Possible Effect on COVID-19

Curcumin supplementation in pediatric patients: A systematic review of current clinical evidence

Study on the Synthesis of Methylated Reference and Their Application in the Quantity of Curcuminoids Using Single Reference Liquid Chromatography Based on Relative Molar Sensitivity

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