Possible mechanisms of dose-dependent cough suppressive effect of Althaea officinalis rhamnogalacturonan in guinea pigs test system

Šutovská, Martina; Nosálóvá, G; Šutovský, Juraj; Fraňová, Soňa; Prisenžňáková, L.; Capek, Peter

doi:10.1016/j.ijbiomac.2009.03.008

Cited by 48 publications

(19 citation statements)

References 25 publications

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“…The experiments were carried out according already described procedure [25]. Briefly, guinea pigs were individually placed in a body pletysmograph box (HSE type 855, Hugo Sachs Elektronik, Germany) and exposed to citric acid aerosol (0.3 M) for 3 min.…”

Section: Methods Of Chemically Induced Cough Reflex and Reactivity Of mentioning

confidence: 99%

Antitussive and immunomodulating activities of instant coffee arabinogalactan-protein

Nosálóvá

Prisenžňáková

Paulovičová

et al. 2011

International Journal of Biological Macromolecules

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Section: Methods Of Chemically Induced Cough Reflex and Reactivity Of mentioning

confidence: 99%

Antitussive and immunomodulating activities of instant coffee arabinogalactan-protein

Nosálóvá

Prisenžňáková

Paulovičová

et al. 2011

International Journal of Biological Macromolecules

Self Cite

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“…From the literature data, it is evident that antitussive activity can be expressed by several polysaccharide types, which vary in chemical structure, i.e ., in monosaccharide composition, content of neutral sugars and uronic acids, presence or absence of branches in their backbones, configuration of linkages, molecular mass, and in other structural details . The aim of this study was to clarify whether there is a relationship between the molecular mass and the antitussive activity of beech hemicelluloses.…”

Section: Resultsmentioning

confidence: 99%

Fagus sylvatica glucuronoxylan sulfate−chemical profile and pharmacological view

et al. 2015

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Glucuronoxylans represent a large group of naturally occurring and renewable biopolymers with a wide range of application possibilities. Controlled depolymerization of Fagus sylvatica 4-Omethylglucuronoxylan afforded three fractions of descending molecular mass, i.e., 3000, 2600, and 1800 g/mol. The native polymer (GX1) and its depolymerized fractions (GX2, GX3, and GX4) were decorated by functional groups to give sulfated products (GXS1, GXS2, GXS3, and GXS4) which were used for pharmacological tests. Antitussive activity tests revealed that the increase in the dose of the glucuronoxylan sulfate (GXS1) from 50 to 100 mg/kg body weight resulted in only slightly increased cough-suppressing effect. This fact indicates that the cough-suppressing effect of the glucuronoxylan sulfate is not dose dependent. Results have shown significant coughsuppressing effect of GXS1, it was only slightly lower than the effect of narcotic codeine. Glucuronoxylan-derived fractions decorated by sulfates (GXS2, GXS3, and GXS4) showed similar cough-suppressing effect as the polymer-sulfate (GXS1) confirming thus that the changes in molecular mass does not affect the cough suppressive activity. Similarly, different contents of sulfate groups in GXS2, GXS3, and GXS4 did not influence their effect. Tests have shown that in the antitussive activity of all glucuronoxylan sulfates a bronchodilation was not involved. During the experiment course, no serious side effects after administration of glucuronoxylan sulfates were observed which is important fact from the application point of view.

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“…Therefore, the activity of K + ATP ion channels is not involved in the full cough-suppressive effect of rhamnogalacturonan. Pretreatment of animals by intraperitoneal injection of ketanserin as selective 5-HT2 serotonergic receptors antagonist reduced the cough-suppressive effects of rhamnogalacturonan partially, and pretreatment of animals by direct administration of ketanserin in nasopharynx completely inhibited the antitussive effects of rhamnogalacturonan [46]. Therefore, the antitussive effects of 5-HT2 rhamnogalacturonan are partly related to 5-HT2 serotonergic receptors.…”

Section: Mechanism Of Action Related To Antitussive Effects Of a Offmentioning

confidence: 95%

Marsh Mallow (<b><i>Althaea officinalis</i></b> L.) and Its Potency in the Treatment of Cough

Mahboubi¹

2019

Complement Med Res

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Althaea officinalis has been traditionally used for manage ment of cough and other respiratory problems. The aim of this review article was to evaluate its efficacy in modern re search according to its traditional beliefs. All information was extracted from scientific resources of PubMed Central, ScienceDirect, Wiley, Springer, SID, accessible books, re ports, and theses. The results of animal and clinical studies confirmed the efficacy of A. officinalis extracts alone in treat ment of dry cough, while combination of A. officinalis with Zataria multiflora, Zingiber officinalis, or Helix hedera in creased the efficacy of A. officinalis and improved all kinds of cough. Different mechanisms are involved in expectorant and antitussive effects of A. officinalis in treatment of cough. Therefore, A. officinalis in combination with other plant ex tracts in different forms of drug could be a good choice for cough, sore throat, and other respiratory ailments. Echter Eibisch (Althaea officinalis L.) und seine Wirksamkeit in der Behandlung von HustenSchlüsselwörter Althaea officinalis · Husten · Rhamnogalacturonan · Expektorans · Antitussivum Zusammenfassung Althaea officinalis wird seit jeher zur Behandlung von Hus ten und anderen Atemwegsproblemen eingesetzt. Ziel des vorliegenden Artikels war die Beurteilung der Wirksamkeit entsprechend den überlieferten Überzeu gungen gemäß den Ergebnissen der modernen For schung. Sämtliche Informationen wurden wissenschaftli chen Quellen von PubMed Central, ScienceDirect, Wiley, Springer, SID, einsehbaren Büchern, Berichten und Dok torarbeiten entnommen. Die Ergebnisse der tierexperi mentellen Untersuchungen und klinische Studien beleg ten die Wirksamkeit von A. officinalisExtrakten als Mono therapie zur Behandlung von trockenem Husten, während die Kombination von A. officinalis mit Zataria multiflora, Zingiber officinalis oder Helix hedera die Wirksamkeit von A. officinalis erhöhte und bei verschiedenen Arten von Husten zu einer Besserung führte. An den schleimlösen den und hustenstillenden Effekten von A. officinalis in der Behandlung von Husten sind verschiedene Mechanismen beteiligt. Daher kann A. officinalis in Kombination mit an deren Pflanzenextrakten in verschiedenen Arzneimittel formen eine gute Wahl bei Husten, Halsschmerzen und Atemwegserkrankungen darstellen.

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Possible mechanisms of dose-dependent cough suppressive effect of Althaea officinalis rhamnogalacturonan in guinea pigs test system

Cited by 48 publications

References 25 publications

Antitussive and immunomodulating activities of instant coffee arabinogalactan-protein

Antitussive and immunomodulating activities of instant coffee arabinogalactan-protein

Fagus sylvatica glucuronoxylan sulfate−chemical profile and pharmacological view

Marsh Mallow (<b><i>Althaea officinalis</i></b> L.) and Its Potency in the Treatment of Cough

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