Possible Mechanisms of Fullerene C<sub><b>60</b></sub>Antioxidant Action

Chistyakov, V. A.; Smirnova, Yu. O.; Празднова, Е. В.; Soldatov, A. V.

doi:10.1155/2013/821498

Cited by 64 publications

(42 citation statements)

References 28 publications

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“…MDM-LPS cells stimulation by PMA tended to reduce the ROS production, particularly when pretreated with 2 , with a statistically significant inhibition of about 30–40%. This result is in agreement with the electron affinity properties of fullerenes C 60 , supporting their capacity to act as radical scavengers [ 23 ], depending on the functionalization that can change the photophysical electrochemical properties and their ROS-generating/quenching capacity [ 24 ]. Therefore, derivative 2 , endowed with a solubility higher than 1 , displayed a better quenching capacity.…”

Section: Resultssupporting

confidence: 76%

Effects of Two Fullerene Derivatives on Monocytes and Macrophages

Pacor

Grillo

Đorđević

et al. 2015

BioMed Research International

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Two fullerene derivatives (fullerenes 1 and 2), bearing a hydrophilic chain on the pyrrolidinic nitrogen, were developed with the aim to deliver anticancer agents to solid tumors. These two compounds showed a significantly different behaviour on human neoplastic cell lines in vitro in respect to healthy leukocytes. In particular, the pyrrolidinium ring on the fullerene carbon cage brings to a more active compound. In the present work, we describe the effects of these fullerenes on primary cultures of human monocytes and macrophages, two kinds of immune cells representing the first line of defence in the immune response to foreign materials. These compounds are not recognized by circulating monocytes while they get into macrophages. The evaluation of the pronecrotic or proapoptotic effects, analysed by means of analysis of the purinergic receptor P2X7 activation and of ROS scavenging activity, has allowed us to show that fullerene 2, but not its analogue fullerene 1, displays toxicity, even though at concentrations higher than those shown to be active on neoplastic cells.

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Section: Resultssupporting

confidence: 76%

Effects of Two Fullerene Derivatives on Monocytes and Macrophages

Pacor

Grillo

Đorđević

et al. 2015

BioMed Research International

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“…The non-water-soluble fullerene (also known as an aqueous dispersion of fullerene), which was termed as C 60 -H 2 O is the present study, has been reported to be a powerful antioxidant with no lethal, acute or subacute effects on liver cells or animals [37,38]. Its anti-oxidant effects may occur via inactivation of hydroxyl radicals which attach to the double bonds or acquire a positive charge, as well as absorption of protons in the mitochondria [39]. However, studies have also shown that it exerts toxic effects in living systems by inducing oxidative stress, such as anti-bacterial or anti-viral effects [10].…”

Section: Discussionmentioning

confidence: 86%

Glycofullerenes Inhibit Particulate Matter Induced Inflammation and Loss of Barrier Proteins in HaCaT Human Keratinocytes

Lee

Chiang

et al. 2020

Biomolecules

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Exposure to particulate matter (PM) has been linked to pulmonary and cardiovascular dysfunctions, as well as skin diseases, etc. PM impairs the skin barrier functions and is also involved in the initiation or exacerbation of skin inflammation, which is linked to the activation of reactive oxygen species (ROS) pathways. Fullerene is a single C60 molecule which has been reported to act as a good radical scavenger. However, its poor water solubility limits its biological applications. The glyco-modification of fullerenes increases their water solubility and anti-bacterial and anti-virus functions. However, it is still unclear whether it affects their anti-inflammatory function against PM-induced skin diseases. Hence, glycofullerenes were synthesized to investigate their effects on PM-exposed HaCaT human keratinocytes. Our results showed that glycofullerenes could reduce the rate of PM-induced apoptosis and ROS production, as well as decrease the expression of downstream mitogen-activated protein kinase and Akt pathways. Moreover, PM-induced increases in inflammatory-related signals, such as cyclooxygenase-2, heme oxygenase-1, and prostaglandin E2, were also suppressed by glycofullerenes. Notably, our results suggested that PM-induced impairment of skin barrier proteins, such as filaggrin, involucrin, repetin, and loricrin, could be reduced by pre-treatment with glycofullerenes. The results of this study indicate that glycofullerenes could be potential candidates for treatments against PM-induced skin diseases and that they exert their protective effects via ROS scavenging, anti-inflammation, and maintenance of the expression of barrier proteins.

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“…Based on this preliminary data, we proposed a possible mechanism by which fullerol may exert its modulatory effect on osteoblast differentiation of mesenchymal stem cells through increasing is hypothesized to play a role in diminishing ROS by fullerol, adding a new idea to the current ones on how fullerol exhibits its antioxidative activity within cells. 56,57 Emphasis should be placed on the fact that the proposed mechanism is currently at its early stage and needs to be further verified by more detailed experimental evidence.…”

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confidence: 99%

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

Yang¹,

Li²,

Wan³

et al. 2014

IJN

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Antioxidants were implicated as potential reagents to enhance osteogenesis, and nano-fullerenes have been demonstrated to have a great antioxidative capacity by both in vitro and in vivo experiments. In this study, we assessed the impact of a polyhydroxylated fullerene, fullerol, on the osteogenic differentiation of human adipose-derived stem cells (ADSCs). Fullerol was not toxic against human ADSCs at concentrations up to 10 μM. At a concentration of 1 μM, fullerol reduced cellular reactive oxygen species after a 5-day incubation either in the presence or in the absence of osteogenic media. Pretreatment of fullerol for 7 days increased the osteogenic potential of human ADSCs. Furthermore, when incubated together with osteogenic medium, fullerol promoted osteogenic differentiation in a dose-dependent manner. Finally, fullerol proved to promote expression of FoxO1, a major functional isoform of forkhead box O transcription factors that defend against reactive oxygen species in bone. Although further clarification of related mechanisms is required, the findings may help further development of a novel approach for bone repair, using combined treatment of nano-fullerol with ADSCs.

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Possible Mechanisms of Fullerene C₆₀Antioxidant Action

Cited by 64 publications

References 28 publications

Effects of Two Fullerene Derivatives on Monocytes and Macrophages

Effects of Two Fullerene Derivatives on Monocytes and Macrophages

Glycofullerenes Inhibit Particulate Matter Induced Inflammation and Loss of Barrier Proteins in HaCaT Human Keratinocytes

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

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Possible Mechanisms of Fullerene C60Antioxidant Action

Cited by 64 publications

References 28 publications

Effects of Two Fullerene Derivatives on Monocytes and Macrophages

Effects of Two Fullerene Derivatives on Monocytes and Macrophages

Glycofullerenes Inhibit Particulate Matter Induced Inflammation and Loss of Barrier Proteins in HaCaT Human Keratinocytes

Antioxidative fullerol promotes osteogenesis of human adipose-derived stem cells

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Possible Mechanisms of Fullerene C₆₀Antioxidant Action