Possible mode of action of anti-tumour platinum drugs: X-ray evidence for cis binding by platinum of two inosine 5′-monophosphate molecules via the N(7) positions

Crystal and molecular structure of dichlorotris(2-methylimidazole)manganese(II); a high-spin pentacoordinate complex of manganese

“…2. We have recently observed a similar pronounced bending at a donor N in the structure of a Pt complex with inosine 5'-monophosphate, [Pt(5'-IMP)2(NH3)2] 2- (Goodgame, Jeeves, Phillips & Skapski, 1975).…”

Metal Complexes of Biologically Important Ligands, Part CLXXVIII. Addition of the Pentacarbonylrhenium Cation [(OC)5Re]+ to the Xanthine Alkaloids Caffeine, Theophylline, and Theobromine

“…Such an O(6)-N(7)-chelate is of interest because of the long and controversial discussion on its possible formation, when cisplatin interacts with guanosine of DNA. [7,29,30] Keppler and co-workers found evidence for the existence of a O(6)-N(7) chelate from guanosine and cisplatin. [30] …”

Characterisation of Metal Binding Sites for 8-Azaguanine and 8-Azahypoxanthine Derivatives Synthesis and X-Ray Structural Analysis of Methylmercury(II) and Zinc(II) Complexes

“…This leads to chain building in the direction of a axis, in which 0 6 and N7 participate in a weakly bonded chelate ring. Such a coordination mode for primary binding has often been suggested for guanine and hypoxanthine complexes [20,21] but has not, as yet, been established by X-ray structural analysis. Our results suggest that with N 9 blocked, N 7 of an 8-azaguanine or 8-azahypoxanthine may not be competitive as a site for metal binding in the DN A in which the 8-aza derivatives act.…”