Possible modes of action of ACTH and glucocorticoids in allergic diseases

Jasani, M K

doi:10.1111/j.1365-2222.1972.tb01266.x

Cited by 8 publications

(5 citation statements)

References 162 publications

(144 reference statements)

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“…Steroids have been shown in vitro to stabilise lysosomal membranes (Weissmann, 1964;Henson, 1971 ;Ignarro, Oronsky and Perper, 1973) and prevent the mobilisation and extracellular release of lysosomal enzymes from phagocytosing leucocytes (Wright and Malawista, 1973). In addition to these actions, it has also been suggested that steroids might act via a local effect upon the reactivity of the tissues by an increase in vascular tone (Jasani, 1972) or even by a systemic action on the complement system (Gewurz, Werwick, Quie and Good, 1965).…”

Section: Discussionmentioning

confidence: 99%

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The effect of anti‐inflammatory compounds on the biochemical changes in the Arthus reaction

Butler

Lewis²

1976

The Journal of Pathology

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The effect of anti-inflammatory drugs on the biochemical changes in the Arthus reaction have been studied and correlated to changes in the pathology of the reaction. In the Arthus reaction all the non-steroidal anti-inflammatory drugs inhibited the migration of cells into the lesion and reduced the lysosomal enzyme concentration at the Arthus site. The steroids did not inhibit the cellular inflitration or the total lysosomal enzyme concentration in the skin but did reduce the concentration of cathepsin D in the oedema fluid. In addition, prednisolone and, to a lesser extent, hydrocortisone reduced the degree of oedema formation. The results suggest that non-steroidal anti-inflammatory drugs inhibit the Arthus reaction by reducing the cellular infiltration whereas anti-inflammatory steroids act by preventing these cells secreting their lysosomal enzymes and thus causing tissue damage.

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Section: Discussionmentioning

confidence: 99%

“…The protein concentration was determined using the method of Lowry, Roseborough, Farr and Randall (1951).…”

Section: Biochemical Methodsmentioning

confidence: 99%

The effect of anti‐inflammatory compounds on the biochemical changes in the Arthus reaction

Butler

Lewis²

1976

The Journal of Pathology

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“…Xylometazoline hydrochloride possesses a topical decongestant effect on the nasal mucosa (8). The corticosteroid drug, Dexamethasone 21-isonicotine, can possibly suppress some types of antigen-antibody reaction (7,10), and one of its side-effects is topical decongestion of the mucosa. However, the whole role and the details of the mode of action of corticosteroids on the various types of the antigen-antibody reaction are not yet fully known.…”

Section: Discussionmentioning

confidence: 99%

“…An alpha-sympathomimetic agent was chosen as a known topical decongestant of the nasal mucosa. Corticosteroids may suppress some types of antigenantibody reaction (7,10) and one of their side-effects is topical decongestion.…”

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confidence: 99%

Effects of Some Drugs Applied Topically to the Nasal Mucosa Before Nasal Provocation Tests With Allergen

Pelikán¹,

Devries²

1974

Allergy

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“…[41]. However, the field has not been well studied, and in most experi ments, reviewed recently by Jasani [15], no consistent effects of steroids on histamine release were demonstrated. We observed inhibition of LCP-mediated histamine release by several glucocorticosteroids at con centrations from 10'8-2 X 1 0 '5 M. The effects were quite variable de pending on the animal used.…”

Section: Discussionmentioning

confidence: 99%

Release of Histamine from Rat Mast Cells by Lysosomal Cationic Proteins

Coffey¹,

Middleton²

1973

Int Arch Allergy Immunol

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Lysosomal cationic protein-mediated release of histamine from isolated rat peritoneal mast cells was inhibited by several compounds capable of increasing cellular levels of cyclic AMP. Histamine release was inhibited to a variable degree by 1–20 µm glucocorticosteroids, 0.05–1.0 mm catecholamines, 0.2–5.0 mm methylxanthines, and by 0.1–2.0 mm dibutyryl cyclic AMP. Β-adrenergic stimulation of adenylate cyclase by isoproterenol and Α-adrenergic stimulation of adenosine triphosphatase by norepinephrine were demonstrated in purified rat mast cells. These findings suggest that the regulation of histamine release by catecholamines may be mediated by Α- as well as by Β-adrenergic receptors. The ability of glucocorticosteroids to stimulate adenylate cyclase and to inhibit adenosine triphosphatase in mast cells suggests that steroids may influence histamine release by mechanisms similar to those involving Β-adrenergic agonists.

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Possible modes of action of ACTH and glucocorticoids in allergic diseases

Abstract: In vivo observations of the effects of cortisone on the vascular reactions to large doses of horse serum using the rabbit ear chamber technique.

Cited by 8 publications

References 162 publications

The effect of anti‐inflammatory compounds on the biochemical changes in the Arthus reaction

The effect of anti‐inflammatory compounds on the biochemical changes in the Arthus reaction

Effects of Some Drugs Applied Topically to the Nasal Mucosa Before Nasal Provocation Tests With Allergen

Release of Histamine from Rat Mast Cells by Lysosomal Cationic Proteins

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