2014
DOI: 10.1186/1471-2466-14-31
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Possible molecular mechanisms linking air pollution and asthma in children

Abstract: BackgroundAir pollution has many effects on the health of both adults and children, but children’s vulnerability is unique. The aim of this review is to discuss the possible molecular mechanisms linking air pollution and asthma in children, also taking into account their genetic and epigenetic characteristics.ResultsAir pollutants appear able to induce airway inflammation and increase asthma morbidity in children. A better definition of mechanisms related to pollution-induced airway inflammation in asthmatic c… Show more

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Cited by 129 publications
(107 citation statements)
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References 72 publications
(79 reference statements)
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“…Residing in proximity to industrial plants, gas station, dumpsite, or construction sites, as well as residing in proximity to overhead power-lines are associated with the respiratory health of adolescents in at least one region in the UAE. This is not surprising given that air quality has been linked to respiratory health (World Health Organization Fact sheet 307; Kelly and Fussell, 2011;Esposito et al, 2014). For instance, adolescents from RAK and Fujairah are less likely to report asthma (7.0 and 9.3% respectively) than those from Abu Dhabi and Western region (16.9 and 12.7%).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Residing in proximity to industrial plants, gas station, dumpsite, or construction sites, as well as residing in proximity to overhead power-lines are associated with the respiratory health of adolescents in at least one region in the UAE. This is not surprising given that air quality has been linked to respiratory health (World Health Organization Fact sheet 307; Kelly and Fussell, 2011;Esposito et al, 2014). For instance, adolescents from RAK and Fujairah are less likely to report asthma (7.0 and 9.3% respectively) than those from Abu Dhabi and Western region (16.9 and 12.7%).…”
Section: Discussionmentioning
confidence: 99%
“…In relation to asthma and respiratory symptoms, several physical environmental factors have been shown to strongly correlate to these health outcomes; these include exposures to allergens, air pollutants, and other environmental chemicals (Kelly and Fussell, 2011). For instance, low levels of air quality due to traffic pollution or high ozone levels have been associated with both asthma development and increased asthma severity (Esposito et al, 2014;NRDC, 2014). In addition, asthma is associated with exposure to indoor allergens including dust mites, cockroaches, animal dander and mold (Bush, 2008;Arshad, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…Exposure to ambient air pollution promotes airway inflammation, which can lead to a decline in lung function and/or lung injury. 22 Similarly, a significant correlation between obesity and systemic inflammation has been reported. 23 Adipokines such as leptin and adiponectin, which mediate the inflammatory response, are produced mainly in adipose tissue.…”
Section: Discussionmentioning
confidence: 99%
“…«Трудноизлечимыми», «резистентными», «неку рабельными», intractable формами эпилепсии на зывают такие, при которых тяжесть и частота при падков, сопутствующие неврологические и психи ческие симптомы и (или) побочные действия антиэпилептических препаратов не поддаются удовлетворительной коррекции, неприемлемы для больного и (или) его близких [9]. Истинная фармако резистентность определяется как неудача в двух попытках применения монотерапии и одного доба вочного АЭП (политерапии), базовых для данного вида приступов, в течение 18 месяцев [13,14].…”
Section: результаты исследования и их обсуждениеunclassified
“…Антиген, поступая в организм, акти вирует тучные клетки, что приводит к секреции ими ряда медиаторов, в том числе и интерлейкина 1 (IL 1). Он стимулирует пролиферацию Т клеток и является главным медиатором развития местной воспалительной реакции при любом типе воспале ния [5,8,13,17]. Другим медиатором, ответствен ным за развитие воспаления по Тh2 пути, является IL 4.…”
Section: Introductionunclassified