Possible nature of the biogenic amine in the dumbbell cell of the frog taste bud

Solov'eva, N. A.; Krokhina, E. M.; Esakov, A. I.

doi:10.1007/bf00800301

Cited by 5 publications

(4 citation statements)

References 4 publications

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“…5HT has been identified with high-performance liquid chromatography (HPLC) in mammalian taste tissues [24]. Histochemical and immunocytochemical techniques have demonstrated that 5HT is present in a subset of Type III taste cells in circumvallate and foliate papillae of mouse, rat, rabbit and monkey [6,[25][26][27][28] and in basal-like Merkel cells in amphibian taste buds [29][30][31]. By using autoradiographic techniques with H 3 -labelled 5HT and exploiting the large taste cells in Necturus taste buds, researchers demonstrated that certain taste cells selectively take up 5HT and release it in a Ca 2+ -dependent manner when depolarized [32].…”

Section: What Neurotransmitters Do Taste Cells Release?mentioning

confidence: 99%

Signaling in the Chemosensory Systems

Roper

2006

Cell. Mol. Life Sci.

106

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Taste bud cells communicate with sensory afferent fibers and may also exchange information with adjacent cells. Indeed, communication between taste cells via conventional and/or novel synaptic interactions may occur prior to signal output to primary afferent fibers. This review discusses synaptic processing in taste buds and summarizes results showing that it is now possible to measure real-time release of synaptic transmitters during taste stimulation using cellular biosensors. There is strong evidence that serotonin and ATP play a role in cell-to-cell signaling and sensory output in the gustatory end organs.

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Section: What Neurotransmitters Do Taste Cells Release?mentioning

confidence: 99%

Signaling in the Chemosensory Systems

Roper

2006

Cell. Mol. Life Sci.

106

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“…Histochemical and immunocytochemical techniques have demonstrated that 5-HT is present in a subset of type III taste cells in foliate and circumvallate papillae of mice, rats, rabbits and monkeys 23,36,45,60,66) and in Merkel-like basal cells in amphibian taste buds 14,57,61) . Using autoradiographic techniques with 3 H-labeled 5-HT and exploiting large taste cells in Necturus, Nagai et al 47) demonstrated that certain taste cells selectively uptake 5-HT and then release it in a Ca ‫ם2‬ -dependent manner when depolarized.…”

Section: Serotoninmentioning

confidence: 99%

Cellular Mechanisms in Taste Buds

Suzuki

2007

Bull. Tokyo Dent. Coll.

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In the soft palate, tongue, pharynx and larynx surrounding the oral region, taste buds are present, allowing the sensation of taste. On the tongue surface, 3 kinds of papillae are present: fungiform, foliate, and circumvallate. Approximately 5,000 taste buds cover the surface of the human tongue, with about 30% fungiform, 30% foliate and 40% circumvallate papillae. Each taste bud comprises 4 kinds of cells, namely high dark (type I), low light (type II), and intermediate (type III) cells in electron density and Merkel-like taste basal cells (type IV) located at a distance from taste pores. Type II cells sense taste stimuli and type III cells transmit taste signals to sensory afferent nerve fibers. However, type I and type IV cells are not considered to possess obvious taste functions. Synaptic interactions that mediate communication in taste cells provide signal outputs to primary afferent fibers. In the study of taste bud cells, molecular functional techniques using single cells have recently been applied. Serotonin (5-HT) plays a role in cell-to-cell transmission of taste signals. ATP fills the criterion of a neurotransmitter that activates receptors of taste nerve fibers. Findings on 5-HT and ATP suggest that various different transmitters and receptors are present in taste buds. However, no firm evidence for tasteevoked release from type III cells has been identified, except for 5-HT and ATP. These results suggest that different transmitters and receptors may not be present in taste buds. Accordingly, an understanding of how transmitters might function remains elusive.

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“…The existence of serotonin in the taste organ has been demonstrated by histological methods in the sheatfish (Reuter, 1971), in rabbits , and in frogs Solovlena, Krokhina, and Esakov, 1978), whereas Takeda (1977) has proposed that in the vallate papilla of mice the 5-hydroxytryptophan can be taken up into taste-bud cells and converted into serotonin.…”

Section: Introductionmentioning

confidence: 99%

Influence of innervation on the levels of noradrenaline and serotonin in the circumvallate papilla of the rat

et al. 1982

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The levels and the distribution of monoamines within the rat circumvallate papilla have been studied. Noradrenaline was found in the connective tissue underlying the taste buds, whereas serotonin was located in the basal area of the gustatory epithelium but not inside the taste buds. Following denervation, noradrenaline levels decreased and serotonin levels increased. These results suggest that both neurotransmitters may have some mutual interaction in modulating transmission at the papilla.

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Possible nature of the biogenic amine in the dumbbell cell of the frog taste bud

Cited by 5 publications

References 4 publications

Signaling in the Chemosensory Systems

Signaling in the Chemosensory Systems

Cellular Mechanisms in Taste Buds

Influence of innervation on the levels of noradrenaline and serotonin in the circumvallate papilla of the rat

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