Possible Neuroprotective Role of Pomegranate Juice in Aluminum Chloride Induced AlzheimerÂ’s Like Disease in Mice

Abdulmalek, Sarah; Suliman, Mansour; Omer, Osman

doi:10.4172/2161-0460.1000188

Cited by 6 publications

(2 citation statements)

References 11 publications

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“…This group showed also significantly decreased average avoidance response through the 5 days of the active avoidance test, indicating impaired memory and cognitive function. In accordance with that, impairment of spatial memory and cognitive functions has been observed in in male Swiss mice using a radial armed maze test 27 and Wistar rats using a Morris water maze and novel object-recognition test. 12 The consistency in the results of both radial arm maze and active avoidance tests in this study indicated that they may evaluate memory processing in a specific region of rat brain.…”

supporting

confidence: 77%

Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects

Balgoon¹

2023

NDT

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Background Bioaccumulation of aluminum in the brain is associated with adverse neuroinflammatory and neurodegenerative changes, such as those seen in Alzheimer’s disease (AD). Objective This study aimed to assess the impact of the administration of Lepidium sativum (LS) extract on behavioral, biochemical, and cerebral histopathological changes in rats with AlCl 3 -induced AD and explore the mechanism behind this effect. Materials and Methods This study was conducted on 40 male albino rats divided into four groups (n=10): LS (control, 20 mg/kg body weight for 8 weeks), AD (AlCl 3, 10 mg/kg body weight), and an LS-treated AD group. Behavioral assessment included radial armed maze and active avoidance training tests. Proinflammatory cytokines, oxidant/antioxidant markers, Aβ, AchE, tau protein, TGFβ 1 , homocysteine, folic acid, and vitamin B 12 were biochemically assessed in the serum. The cerebral cortex was histopathologically examined. Results AlCl 3 administration significantly impaired rats’ memory, indicating AD-like behavioral changes, significantly increased ( P <0.001) oxidative stress markers, enhanced proinflammatory cytokines, and significantly increased AChE ( P <0.001) adding to cytotoxic effects and neuronal loss in the cerebral cortex. LS administration significantly improved the antioxidant parameters, reduced proinflammatory cytokines, and alleviated AD-associated histopathological changes. Conclusion LS ameliorated AlCl 3 -induced changes through its antioxidant, anti-inflammatory, and antiapoptotic effects, suggesting that it has a neuroprotective effect.

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supporting

confidence: 77%

Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects

Balgoon¹

2023

NDT

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“…This result is consistent with another finding that pomegranate juice supplementation improves learning and memory in mice with an AD-like condition induced by aluminium chloride. However, pomegranate juice does not inhibit oxidative damage of the brain tissue in these rodents 50 (Fig. 1).…”

Section: Pomegranate (Punica Granatum L)mentioning

confidence: 89%

Alzheimer’s Disease and Functional Foods: An Insight on Neuroprotective Effect of its Combination

Rosli¹,

Yahya²,

Shahar³

et al. 2020

Pakistan J. of Biological Sciences

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Alzheimerʼs disease (AD) is a progressive neurodegenerative disease which impairs memory and cognitive function. Currently, AD has no cure and treatments are focused on relieving its symptoms. Several functional plants and foods, such as pomegranate, date fruits, honey, black seeds and figs, possess nutritious properties which alleviate AD. In vitro and in vivo studies reported that these functional foods exert neuroprotective effects through their antioxidant and anti-inflammatory properties. This review are going to discusses the bioactive components and neuroprotective activities of the functional foods such as pomegranate, dates, honey, black seeds and figs and the potential of functional foods combinations to alleviate AD. Functional food combinations have potential to be consumed for health benefit for the prevention and treatment of AD. This review summarises the functional foods which can be useful for the prevention, treatment and management of AD via oxidative and inflammatory mechanisms. Besides, it provides a new insight on the potential of functional food combinations for the prevention and treatment of AD.

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Phytochemical: a treatment option for heavy metal induced neurotoxicity

Mishra¹,

Awasthi²,

Srivastava³

et al. 2022

Journal of Complementary and Integrative Medicine

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Heavy metals are known to be carcinogenic, mutagenic, and teratogenic. Some heavy metals are necessary while present in the growing medium in moderate concentrations known to be essential heavy metals as they required for the body functioning as a nutrient. But there are some unwanted metals and are also toxic to the environment and create a harmful impact on the body, which termed to be non-essential heavy metals. Upon exposure, the heavy metals decrease the major antioxidants of cells and enzymes with the thiol group and affect cell division, proliferation, and apoptosis. It interacts with the DNA repair mechanism and initiates the production of reactive oxygen species (ROS). It subsequently binds to the mitochondria and may inhibit respiratory and oxidative phosphorylation in even low concentrations. This mechanism leads to damage antioxidant repair mechanism of neuronal cells and turns into neurotoxicity. Now, phytochemicals have led to good practices in the health system. Phytochemicals that are present in the fruits and herbs can preserve upon free radical damage. Thus, this review paper summarized various phytochemicals which can be utilized as a treatment option to reverse the effect of the toxicity caused by the ingestion of heavy metals in our body through various environmental or lifestyles ways.

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Possible Neuroprotective Role of Pomegranate Juice in Aluminum Chloride Induced AlzheimerÂ’s Like Disease in Mice

Cited by 6 publications

References 11 publications

Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects

Garden Cress (Lepidium sativum) Seeds Ameliorated Aluminum-Induced Alzheimer Disease in Rats Through Antioxidant, Anti-Inflammatory, and Antiapoptotic Effects

Alzheimer’s Disease and Functional Foods: An Insight on Neuroprotective Effect of its Combination

Phytochemical: a treatment option for heavy metal induced neurotoxicity

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