Possible nitric oxide modulation in the protective effect of trazodone against sleep deprivation-induced anxiety like behavior and oxidative damage in mice

Kumar, Amit; Garg, Renu

doi:10.4314/ijhr.v1i3.55362

Cited by 3 publications

(3 citation statements)

References 39 publications

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“…Réus and colleagues (2010) recently showed that imipramine also presents antioxidant properties, reducing oxidative damage and increasing superoxide dismutase and catalase activity in the rat brain. Additionally, imipramine (10 and 20 mg/kg) restored depleted reduced glutathione levels and catalase activity and attenuated raised lipid peroxidation and nitrite concentrations in sleep-deprived mice compared to untreated sleep-deprived mice (Kumar and Garg 2009). Thus, the effects of imipramine in preventing the changes in the behavioral tasks observed in H-BCAA rats might be also associated with its capability to maintain pro-/anti-oxidative homeostasis.…”

Section: Discussionmentioning

confidence: 94%

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

et al. 2013

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Maple syrup urine disease (MSUD) is an inborn metabolism error caused by a deficiency of branched-chain a-keto acid dehydrogenase complex activity. This blockage leads to an accumulation of the branched-chain amino acids (BCAA) leucine, isoleucine, and valine, as well as their corresponding a-keto and a-hydroxy acids. Previous reports suggest that MSUD patients are at high risk for chronic neuropsychiatric problems. Therefore, in this study, we assessed variables that suggest depressive-like symptoms (anhedonia as measured by sucrose intake, immobility during the forced swimming test and body and adrenal gland weight) in rats submitted to chronic administration of BCAA during development. Furthermore, we determined if these parameters were sensitive to imipramine and N-acetylcysteine/deferoxamine (NAC/DFX). Our results demonstrated that animals subjected to chronic administration of branched-chain amino acids showed a decrease in sucrose intake without significant changes in body weight. We also observed an increase in adrenal gland weight and immobility time during the forced swimming test. However, treatment with imipramine and NAC/DFX reversed these changes in the behavioral tasks. In conclusion, this study demonstrates a link between MSUD and depression in rats. Moreover, this investigation reveals that the antidepressant action of NAC/DFX and imipramine might be associated with their capability to maintain pro-/anti-oxidative homeostasis.

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Section: Discussionmentioning

confidence: 94%

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

et al. 2013

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“…Antioxidants, such as N-acetyl-cysteine, compounds that mimic GPX activity, and zinc exhibit antidepressive effects [156]. In a recent study, Kumar and Garg [157] demonstrated the efficacy of trazodone and imipramine in the treatment of sleep deprivation-induced anxiety-like behavior and oxidative damage in mice, through the restoration of reduced glutathione levels, catalase activity and attenuation of raised lipid peroxidation and nitrite concentrations as compared to untreated sleep-deprived animals.…”

Section: Mood and Psychiatric Disorders And Os-targeting Approachesmentioning

confidence: 99%

Redox proteomics and drug development

D’Alessandro

Rinalducci

Zolla

2011

Journal of Proteomics

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“…The apparatus was placed in a darkened, light and sound attenuated and ventilated testing room [6,7].…”

Section: Measurement Of Spontaneous Motor Activitymentioning

confidence: 99%

Cadmium Enhances Locomotor Behaviour in F1 Generation Mice Following Maternal Exposure During Lactation: Modulation by Quercetin

Halder¹,

Kar²,

Ch³

et al. 2017

Ann of Behav Sci

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The present study was designed to investigate the effects of Cd exposure on locomotor behaviour in F1 mice whose dams were exposed to low dose cadmium for a short duration during the lactation period and whether quercetin could modulate the effects. The locomotor behaviour and musculoskeletal activity were tested using photoactomter and rota rod test respectively. We observed that at the given dose of Cd (1.2mg/kg) for a short duration, the muscle coordination on rota rod showed significant improvement as compared to the control group. Cotreatment of Cd with quercetin (100mg/kg) further enhanced the rota rod activity. Similarly the spontaneous motor activity as tested on the photoactometer also exhibited improvement in Cd treated group though this change was not statistically significant. However, Cd when cotreated with quercetin (50 mg/kg) showed significant enhancement in photoactometer activity compared to control. Quercetin administered alone (dose 25 mg/kg) also demonstrated significantly improved rota rod and photoactometer activity as compared to control. Thus cadmium exposure to dams at dose (1.2mg/kg) during lactation may cause enhanced locomotor behaviour in their offsprings.

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Possible nitric oxide modulation in the protective effect of trazodone against sleep deprivation-induced anxiety like behavior and oxidative damage in mice

Cited by 3 publications

References 39 publications

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

Behavioral Responses in Rats Submitted to Chronic Administration of Branched-Chain Amino Acids

Redox proteomics and drug development

Cadmium Enhances Locomotor Behaviour in F1 Generation Mice Following Maternal Exposure During Lactation: Modulation by Quercetin

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