Possible Predictive Markers of Response to Therapy in Esophageal Squamous Cell Cancer

László, Zsuzsanna; Farkas, Róbert; Pozsgai, Éva; Papp, András; Bognár, Laura; Tornóczki, Tamás; Mangel, László; Bellyei, Szabolcs

doi:10.1007/s12253-017-0342-z

Cited by 7 publications

(6 citation statements)

References 42 publications

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“…Although Hsp16.2 has been shown to inhibit cell death by binding to Hsp90, and through the activation of the PI-3kinase/Akt pathway [ 30 ] and was also been found to be overexpressed in esophageal cancer [ 62 ], the intensity of the Hsp 16.2 staining showed no significant relationship with either the time to metastasis or 10-year OS in our present study. Furthermore, both Hsp16.2 and SOUL were predictors of a negative response to NRCT in esophageal cancer according to a previous report [ 63 ], yet neither protein correlated with the survival rate in our patients.…”

Section: Discussioncontrasting

confidence: 77%

Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer

et al. 2023

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Background: Rectal cancer constitutes nearly one-third of all colorectal cancer diagnoses, and certain clinical and molecular markers have been studied as potential prognosticators of patient survival. The main objective of our study was to investigate the relationship between the expression intensities of certain proteins, including growth-hormone-releasing hormone receptor (GHRH-R), Hsp90, Hsp16.2, p-Akt and SOUL, in specimens of locally advanced rectal cancer patients, as well as the time to metastasis and 10-year overall survival (OS) rates. We also investigated whether these outcome measures were associated with the presence of other clinical parameters. Methods: In total, 109 patients were investigated retrospectively. Samples of pretreatment tumors were stained for the proteins GHRH-R, Hsp90, Hsp16.2, p-Akt and SOUL using immunhistochemistry methods. Kaplan–Meier curves were used to show the relationships between the intensity of expression of biomarkers, clinical parameters, the time to metastasis and the 10-year OS rate. Results: High levels of p-Akt, GHRH-R and Hsp90 were associated with a significantly decreased 10-year OS rate (p = 0.001, p = 0.000, p = 0.004, respectively) and high expression levels of p-Akt and GHRH-R were correlated with a significantly shorter time to metastasis. Tumors localized in the lower third of the rectum were linked to both a significantly longer time to metastasis and an improved 10-year OS rate. Conclusions: Hsp 90, pAkt and GHRH-R as well as the lower-third localization of the tumor were predictive of the 10-year OS rate in locally advanced rectal cancer patients. The GHRH-R and Hsp90 expression levels were independent prognosticators of OS. Our results imply that GHRH-R could play a particularly important role both as a molecular biomarker and as a target for the anticancer treatment of advanced rectal cancer.

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Section: Discussioncontrasting

confidence: 77%

Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer

et al. 2023

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“…HSP 27 overexpression imposes a poorer long-term survival [ 46 , 47 , 48 ]. Nonetheless, HSP 16.2 and 70 are not considered independent predictors of overall survival [ 21 , 47 , 49 ].…”

Section: Literature Reviewmentioning

confidence: 99%

“…Another contribution of the heat shock proteins to esophagogastric therapy is their potential role as biomarkers for predicting the response to neoadjuvant therapy. Zoltan et al [ 49 ] evaluated the pretreatment expression HSP 16.2 in esophageal squamous cell carcinoma biopsies. The authors found that the expression levels of HSP 16.2 were significantly correlated with poor clinical and pathological responses.…”

Section: Literature Reviewmentioning

confidence: 99%

The Role of the Heat-Shock Proteins in Esophagogastric Cancer

Tustumi

Agareno

Galletti

et al. 2022

Cells

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Heat-shock proteins (HSPs) are a family of proteins that have received considerable attention over the last several years. They have been classified into six prominent families: high-molecular-mass HSP, 90, 70, 60, 40, and small heat shock proteins. HSPs participate in protein folding, stability, and maturation of several proteins during stress, such as in heat, oxidative stress, fever, and inflammation. Due to the immunogenic host’s role in the combat against cancer cells and the role of the inflammation in the cancer control or progression, abnormal expression of these proteins has been associated with many types of cancer, including esophagogastric cancer. This study aims to review all the evidence concerning the role of HSPs in the pathogenesis and prognosis of esophagogastric cancer and their potential role in future treatment options. This narrative review gathers scientific evidence concerning HSPs in relation to esophagus and gastric cancer. All esophagogastric cancer subtypes are included. The role of HSPs in carcinogenesis, prognostication, and therapy for esophagogastric cancer are discussed. The main topics covered are premalignant conditions for gastric cancer atrophic gastritis, Barrett esophagus, and some viral infections such as human papillomavirus (HPV) and Epstein–Barr virus (EBV). HSPs represent new perspectives on the development, prognostication, and treatment of esophagogastric cancer.

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“…Furthermore, along with GHRH-R, Hsp90 was found to be an independent prognosticator of OS in our study. Although Hsp16.2 has been shown to inhibit cell death by binding to Hsp90 and through the activation of the PI-3kinase/Akt pathway [24] and was also been found to be overexpressed in esophageal cancer [52],…”

Section: Analysis Of the Expression Of Pre-treatment Proteins And Cli...mentioning

confidence: 99%

Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer

Dávid¹,

Eva²,

V.³

et al. 2022

Int J Cancer Clin Res

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Background:Rectal cancer constitutes nearly one-third of all colorectal cancer diagnoses and certain clinical and molecular markers have been studied as potential prognosticators of patient survival. The main objective of our study was to investigate the relationship between the expression intensities of certain proteins: Growth Hormone-Releasing Hormone Receptor (GHRH-R), Hsp90, Hsp16.2, p-Akt and SOUL in specimens of locally advanced rectal cancer patients and time to metastasis as well as 10-year Overall Survival (OS). We also investigated whether these outcome measures were associated with the presence of other clinical parameters.Methods: 109 patients were investigated retrospectively. Samples of pretreatment tumors were stained for proteins GHRH-R, Hsp90, Hsp16.2, p-Akt and SOUL using immunhistochemistry methods. Kaplan-Meier curves were used to show the relationship between intensity of expression of biomarkers, clinical parameters, time-to metastasis and 10-year OS.Results: High levels of p-Akt, GHRH-R and Hsp90 were associated with significantly decreased 10-year OS (p = 0.001; p = 0.000; p = 0.004, respectively) and high expression levels of p-Akt and GHRH-R were correlated with significantly shorter time to metastasis. Tumors localized in the lower third of the rectum were linked to both significantly longer time to metastasis and improved 10-year OS. Conclusion:Hsp 90, pAkt and GHRH-R as well as the lower-third localization of the tumor were predictive of 10year OS in locally advanced rectal cancer patients. GHRH-R and Hsp90 expression were independent prognosticators of OS. Our results imply that GHRH-R could play a particularly important role both as a molecular biomarker and as a target for anticancer treatment of advanced rectal cancer.

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Possible Predictive Markers of Response to Therapy in Esophageal Squamous Cell Cancer

Cited by 7 publications

References 42 publications

Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer

Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer

The Role of the Heat-Shock Proteins in Esophagogastric Cancer

Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer

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