The use of herbal drugs as alternative and complementary medicine has increased in
popularity, raising concerns about their safety profile. Aloe vera, a plant with diverse therapeutic
properties, has been extensively used for centuries. This review aims to assess the therapeutic
activity and safety profile of Aloe vera. A comprehensive literature search was conducted to
gather relevant information from various biomedical databases. The chemical composition,
mechanism of action, and therapeutic activities of Aloe vera were analyzed. Aloe vera contains
numerous active components such as vitamins, enzymes, minerals, sugars, lignin, saponins, and
anthraquinones. Its mechanisms of action involve collagen synthesis, anti-inflammatory effects,
immune modulation, laxative properties, and antiviral activity. Aloe vera has demonstrated potential therapeutic benefits in wound healing, diabetes management, liver and kidney protection,
and glycemic control. However, it is essential to consider potential side effects, such as skin irritation and allergic reactions. This review provides evidence-based information to improve patient safety and promote informed decisions regarding the use of Aloe vera as a therapeutic
agent.