Possible Protection by Breast-Feeding against Severe Esophageal and Gastric Lesions in the Neonate

Benhamou, PH; Cheikh, Amine; Francoual, C; Kalach, Nicolas; Boissieu, D. de; Dupont, Christophe

doi:10.1159/000013993

Cited by 9 publications

(5 citation statements)

References 10 publications

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“…A possible protective role of breastfeeding was shown by our first case control study (23) in 24 neonates with esophagogastric lesions and matched controls from the same maternity unit. Clinical and obstetric data were not different in the two groups, whereas breastfeeding was less frequent (P , 0.01) and given later (P = 0.0001) in babies with esophagogastric lesions.…”

Section: Factors Associated With Mucosalmentioning

confidence: 82%

“…Severe general symptoms in the form of apparent lifethreatening events led to the discovery of severe lesions of esophagus and stomach in two different neonatal cases (18,19). The series describing apparent life-threatening events during the first days of life in mature and apparently healthy neonates are scarce and comprise a limited number of patients whose digestive tract was not investigated (20)(21)(22)(23). The potential relationship between apparent life-threatening events and severe esophagogastric lesions found in the case reports cited above should probably not be overlooked.…”

Section: Upper Digestive Endoscopy Clinical Symptoms In the Neonatal ...mentioning

confidence: 99%

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Digestive Endoscopy in Neonates

Dupont¹,

Kalach²,

Boissieu³

et al. 2005

J. pediatr. gastroenterol. nutr.

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Since the introduction of flexible fiberoptic endoscopy in the early 1970s, esophagogastro-duodenoscopy and colonoscopy have become established procedures for the diagnosis, evaluation and treatment of gastrointestinal tract disease in the pediatric population. The development of safe fiberoptic endoscopes specially designed for neonates has allowed visualization of lesions occurring in the first days of life. Despite an increased understanding of neonatal digestive disorders deriving from this new diagnostic modality, there is little consensus on the appropriate use of endoscopic procedures in routine care of neonates. It is the feeling of the authors that widening the indications of endoscopy in the neonatal period might lead to diagnosis of discrete clinical abnormalities, which might improve the care of neonates. The techniques for performing neonatal endoscopies, the appropriate indications, the common normal and pathologic findings and the complications of these procedures are reviewed.

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Section: Factors Associated With Mucosalmentioning

confidence: 82%

Section: Upper Digestive Endoscopy Clinical Symptoms In the Neonatal ...mentioning

confidence: 99%

Digestive Endoscopy in Neonates

Dupont¹,

Kalach²,

Boissieu³

et al. 2005

J. pediatr. gastroenterol. nutr.

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“…The role of neonatal or maternal stress is supported by a higher incidence in clinical histories of the threat of premature labor (5) and acute fetal distress (6). Two recent case–control studies indicate a possible protection afforded by breast‐feeding (11) and the potentially noxious role of antacid treatment during pregnancy (12).…”

Section: Discussionmentioning

confidence: 99%

Apparent Life‐Threatening Events in a Neonate With Severe Lesions of Esophagus and Stomach

Dupont,

Berg,

Lagueunie

et al. 2000

J. pediatr. gastroenterol. nutr.

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“…Various risk factors have been suggested, including traumatic upper digestive tract suction (5), fetal distress (1), and maternal stress (6). Breast-feeding during the first days of life has been found to have a protective effect (7).…”

mentioning

confidence: 99%

Risk Factors for Severe Esophageal and Gastric Lesions in Term Neonates: A Case–Control Study

Benhamou,

Francoual,

Glangeaud

et al. 2000

J. pediatr. gastroenterol. nutr.

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BackgroundThe purpose of this multicenter case–control study was to search for causes and risk factors related to the severe upper digestive tract lesions often seen in neonates.MethodsCase patients were full‐term neonates with endoscopically confirmed severe bleeding or ulcerative lesions of the esophagus and/or stomach. Matched control subjects were the next infant born in the same maternity unit who met the same criteria and had no clinical abnormality (and, for ethical reasons, no endoscopy). The analysis was based on 137 case–control pairs and considered data showing the mothers' medical and obstetric background, the infants' clinical status and laboratory results, feeding details, and the State and Trait Anxiety Inventory (STAI) questionnaire, which was used to assess the anxiety of the mothers.ResultsCases and controls did not differ in any demographic or social factors. Antacid and anti‐ulcer drugs were used significantly more frequently during the last month of pregnancy by case mothers than by control mothers (28% and 10%, respectively;P < 0.001). Mode of delivery was similar. Case infants more frequently experienced cardiac deceleration during labor and delivery (28% and 12.9%;P = 0.003). Breast‐feeding at birth was less frequent for case infants (36% and 49%;P = 0.05). The mean trait anxiety scores did not differ between the two groups, but the mean state anxiety score was higher in case mothers. Multivariate logistic regression found that three factors were independently and significantly associated with esophageal and gastric lesions: use of antacid and antiulcer treatments (odds ratio [OR], 3.9;P < 0.001), cardiac deceleration (OR, 2.2;P = 0.03), and breast‐feeding (OR, 0.5;P = 0.02).ConclusionsAntacid drug use by mothers during the last month of pregnancy was associated with esophageal and gastric lesions. Breast‐feeding may play a protective role against severe lesions in neonates.

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Possible Protection by Breast-Feeding against Severe Esophageal and Gastric Lesions in the Neonate

Cited by 9 publications

References 10 publications

Digestive Endoscopy in Neonates

Digestive Endoscopy in Neonates

Apparent Life‐Threatening Events in a Neonate With Severe Lesions of Esophagus and Stomach

Risk Factors for Severe Esophageal and Gastric Lesions in Term Neonates: A Case–Control Study

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