Possible protective effect of gum arabic on experimentally induced gastric ulcer in adult male albino rats

Helal, Omayma K.; Yousef, Mohamed; El-Naa, Mona M.

doi:10.1097/ehx.0000399971.18980.f6

Cited by 14 publications

(6 citation statements)

References 38 publications

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“…The result of the experiment revealed that pre-treated with GA reduced stomach lesions considerably. Significant reduction in ulcer score and severity has been observed (39.58 % and 32.8 %) in comparing with the stress-untreated group (34).…”

Section: Acacia Arabicamentioning

confidence: 81%

Phytotherapy for Peptic-ulcer: An overview on important Indian herbal plants having flavonoid as antiulcer activity.

Mazumder¹,

Yadav

Sharma³

2021

Plant Sci. Today

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Peptic ulcers are described by erosions of the gastrointestinal mucosa that can reach the muscular layer. Peptic ulcers are a widespread health condition that affects millions of individuals and has a high recurrence rate. “No gastric acid, no peptic ulcer” is a flawed assumption. Excessive gastric acid secretion is only one factor in the pathogenesis of peptic ulcer disease. Their etiology is multifactorial and develops when the balance of offensive and protective components is disrupted. Its treatment faces great difficulties due to the limited effectiveness and severe side effects of the currently available drugs. Natural products such as herbal plants and their isolated compounds have been widely used in experimental models of peptic ulcers. Flavonoids strengthened defensive factors had cytoprotective and rehabilitative actions. Flavonoids are among the molecules of greatest interest in biological assays due to their anti-inflammatory, antioxidant properties. The present study is a literature review of herbal plants having flavonoid that have been reported to show peptic ulcer activity in experimental models using the divergent mechanism of action.

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Section: Acacia Arabicamentioning

confidence: 81%

Phytotherapy for Peptic-ulcer: An overview on important Indian herbal plants having flavonoid as antiulcer activity.

Mazumder¹,

Yadav

Sharma³

2021

Plant Sci. Today

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“…Similarly, Pal et al (2013) suggested that AG could protect the body from ROS effect through two defense mechanisms, primary by antioxidant activity that capable of catalytically removing ROS and the second mechanism by free radical scavengers. Helal et al (2011) observed that AG treatment led to mild PCNA expression in gastric gland.…”

Section: Discussionmentioning

confidence: 98%

Effect of Arabic Gum Aqueous Extract on Histological, Ultrastructural, Immunohistochemical and Biochemical Changes on Colistin-Induced Nephropathy in Male Albino Rats

Arisha

2020

Egyptian Academic Journal of Biological Sciences, D. Histology

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“…Arabic gum (GA) has been shown to protect against hepatic and renal toxicities in mice and rats (Nemmar et al, 2019). Its anti-oxidant, anti-inflammatory, and cytoprotective qualities are probably responsible for these protective effects (Helal et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Effect of Prebiotic, Probiotic Bacteria and Symbiotic Diets Containing Bacillus Coagulans and Gum Arabic on Lipid Profile in Hypercholesterolemic Rats

Altawari

2024

IJF

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Purpose: Hypercholesterolemia poses a significant challenge for numerous communities and healthcare professionals because of the association between cardiovascular conditions and dyslipidemia. The objective of this research was to assess the impact of prebiotics, probiotics, as well as a diet incorporating Bacillus coagulants and gum Arabic on blood lipid levels in hypercholesterolemic rats. Methodology: In order to create an antiseptic solution, acquire the organic substance known as gum Arabic. Thirty-five male Albino rats (170 ± 5 g) were feeding a prepared diet includes supplemented cholesterol to raise the levels of cholesterol. Mice were divided to 5 groups (n = 7). Group 1: simple diet (negative control), the other 4 groups were assigned for a hypercholesterolemia diet comprising 25% lard and 2% cholesterol for 6 weeks in order to increase fat cholesterol in rats. Group 2: (positive control), Group 3: fed with a supplement including 5% gum Arabic (prebiotic), Group 4: fed with a dietary supplement comprising coagulase spores, Group 5: assigned for a simple meal. It was supplemented with 5% daily gum Arabic and Bacillus coagulants spores (symbiotic). Results: Triglyceride levels and total cholesterol (mg/dL) were improved (P<0.05). In (advantageous manipulate) fed a simple diet (B.D.), compared with (poor manipulate). Unique Contribution to theory, Practice and Policy: The Anti-Inflammatory Theory and the concept of prebiotics usage to decrease cholesterol and minimize its absorption. This shows that the concept used has been validated. The satisfactory results which confirmed the extreme spread variations with the poor manipulate organization had been done within side the hypercholesterolemia organizations include with Gum Arabic (GA5%), where the best indicated a fee recorded (28.54 ± 3. seventy one mg/dL), which transferred into the poor manipulate (36.33 ± 5.00 mg/dL). As for the organizations that took B. coagulants and GA 5% + B. coagulants, a lower in LDL-c, (VLDL-c), levels of AST and AST, and the satisfactory outcome documented and directed within side of the organization GA 5% + B.Coagulants. Histological checkups furthermore confirmed that the liver sections inside the 5th organization established a regular structure, also the liver cells mild degeneration. CONCLUSION: The satisfactory final outcome indicated within side the organization of GA 5%+ B. coagulants remedy organization compared with the opposite organizations.

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Possible protective effect of gum arabic on experimentally induced gastric ulcer in adult male albino rats

Cited by 14 publications

References 38 publications

Phytotherapy for Peptic-ulcer: An overview on important Indian herbal plants having flavonoid as antiulcer activity.

Phytotherapy for Peptic-ulcer: An overview on important Indian herbal plants having flavonoid as antiulcer activity.

Effect of Arabic Gum Aqueous Extract on Histological, Ultrastructural, Immunohistochemical and Biochemical Changes on Colistin-Induced Nephropathy in Male Albino Rats

Effect of Prebiotic, Probiotic Bacteria and Symbiotic Diets Containing Bacillus Coagulans and Gum Arabic on Lipid Profile in Hypercholesterolemic Rats

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