Possible Recurrent Pandemic (H1N1) 2009 Infection, Israel

Kopel, Eran; Mandelboim, Michal; Amitai, Ziva; Grotto, Itamar; Hindiyeh, Musa; Kaliner, Ehud; Mendelson, Ella; Volovik, Irina

doi:10.3201/eid1608.100436

Cited by 4 publications

(8 citation statements)

References 7 publications

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“…In addition, consecutive infection with influenza A and B viruses within a single season has been demonstrated . Recurrent within‐season influenza A (H1N1) infections have also been reported for two immunocompetent, but high‐risk patients . Here, we report a unique case of two sequential, within‐season infections with highly similar influenza A (H3N2) viruses in a usually healthy vaccinated child.…”

Section: Introductionmentioning

confidence: 81%

Sequential, within‐season infection with influenza A (H3N2) in a usually healthy vaccinated child

Temte

Uzicanin

Goss

et al. 2019

Influenza Resp Viruses

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Section: Introductionmentioning

confidence: 81%

Sequential, within‐season infection with influenza A (H3N2) in a usually healthy vaccinated child

Temte

Uzicanin

Goss

et al. 2019

Influenza Resp Viruses

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“…The evidence of re-infection in the subsequent season [ 33 ] or within the same season [ 38 , 39 ] supports the adverse effect of both neuraminidase inhibitors on the immune system.…”

Section: Mechanism For Delayed Onset Type Reactionsmentioning

confidence: 91%

“…Several cases of re-infection with the same influenza virus within one season were reported. [ 38 , 39 ] Kopel et al. [ 38 ] reported a 13-year-old boy with cerebral palsy who three times had episodes of fevering with positive 2009A/H1N1 influenza detected by the RT-PCR method.…”

Section: Evidence On Adverse Reactions To Oseltamivir In Humans and Imentioning

confidence: 99%

“…[ 38 , 39 ] Kopel et al. [ 38 ] reported a 13-year-old boy with cerebral palsy who three times had episodes of fevering with positive 2009A/H1N1 influenza detected by the RT-PCR method. He was treated with the standard dose (75mg b.i.d for 5 days) of oseltamivir at the time of the first episode.…”

Section: Evidence On Adverse Reactions To Oseltamivir In Humans and Imentioning

confidence: 99%

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The mechanisms of delayed onset type adverse reactions to oseltamivir

Hama

2016

Infectious Diseases

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Oseltamivir is recommended for the treatment and prophylaxis of influenza in persons at higher risk for influenza complications such as individuals with diabetes, neuropsychiatric illnesses, and respiratory, cardiac, renal, hepatic or haematological diseases. However, a recent Cochrane review reported that reduction of antibody production, renal disorders, hyperglycaemia, psychiatric disorders, and QT prolongation may be related to oseltamivir use. The underlying mechanisms are reviewed. There is decisive evidence that administration of a clinically compatible dose of oseltamivir in mice challenged by a respiratory syncytial virus (RSV) that lacks a neuraminidase gene showed symptom-relieving effects and inhibition of viral clearance. These effects were accompanied by decreased level of T cell surface sialoglycosphingolipid (ganglioside) GM1 that is regulated by the endogenous neuraminidase in response to viral challenge. Clinical and non-clinical evidence supports the view that the usual dose of oseltamivir suppresses pro-inflammatory cytokines such as interferon-gamma, interleukin-6, and tumour necrosis factor-alpha almost completely with partial suppression of viral shedding in human influenza virus infection experiment. Animal toxicity tests support the clinical evidence with regard to renal and cardiac disorders (bradycardia and QT prolongation) and do not disprove the metabolic effect. Reduction of antibody production and cytokine induction and renal, metabolic, cardiac, and prolonged psychiatric disorders after oseltamivir use may be related to inhibition of the host’s endogenous neuraminidase. While the usual clinical dose of zanamivir may not have this effect, a higher dose or prolonged administration of zanamivir and other neuraminidase inhibitors may induce similar delayed reactions, including reduction of the antibody and/or cytokine production.

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“…The elution volume was 55 µL. The real-time RT-PCR was performed by an in-house protocol previously described (Panning et al, 2009), according to the instructions of the Central Virology Laboratory in Israel (Kopel et al, 2010). Briefly, the real-time RT-PCR reaction was carried out in 25 µL volume containing 5 µL of the RNA extract in the AgPath-ID one-step RT-PCR kit (Ambion, Applied Biosystems, Foster City, CA, USA) and a set of primers (300 nM) and a TaqMan probe [200 nM0 targeting the hemagglutinin (HA) gene].…”

Section: Methodsmentioning

confidence: 99%

Salivary Detection of H1N1 Virus: A Clinical Feasibility Investigation

Bilder¹,

Machtei²,

Shenhar³

et al. 2011

J Dent Res

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The fast and efficient transportation among continents will continue to play a role in the spread of airborne pandemics. The objective of this study was to detect H1N1 virus in the saliva of individuals who visited the emergency department and were diagnosed as having H1N1 influenza. Nasopharyngeal swabs and saliva samples from those who presented to the emergency department with flu-like symptoms were sent to the laboratory. RNA was extracted from both samples. Real-time RT-PCR tests were performed, and the saliva and nasopharyngeal swab tests were compared. Samples were drawn from 26 individuals. A positive nasopharyngeal swab test and salivary test was found in 14 persons, and negative tests were found in 12 persons. Saliva sampling for H1N1 has excellent predictive value, is highly accurate and reliable, and is more convenient than the nasopharyngeal swab. Clinical trial with the Helsinki Committee at Rambam Health Care Campus, registration number 036309-RMB.

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Possible Recurrent Pandemic (H1N1) 2009 Infection, Israel

Cited by 4 publications

References 7 publications

Sequential, within‐season infection with influenza A (H3N2) in a usually healthy vaccinated child

Sequential, within‐season infection with influenza A (H3N2) in a usually healthy vaccinated child

The mechanisms of delayed onset type adverse reactions to oseltamivir

Salivary Detection of H1N1 Virus: A Clinical Feasibility Investigation

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