Possible regulatory factors for intra-abdominal fat mass in a rat model of Parkinson's disease

Kuranuki, Sachi; Arai, Chie; Terada, Shin; Aoyama, Toyohiko; Nakamura, Teiji

doi:10.1016/j.nut.2009.12.002

Cited by 11 publications

(4 citation statements)

References 21 publications

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“…Many studies have investigated the factors associated with weight loss in PD patients or animal models (Kuranuki et al, 2011;Guimarães et al, 2013;Vikdahl et al, 2014). Recently, it has been suggested that weight loss in PD patients is mostly the result of decreased adipose tissues (Loref€ alt et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…However, although PD‐model rats show decreased intra‐abdominal fat, total weight loss in these rats is unaffected. Kuranuki et al () reported that injection of 6‐OHDA into the striatum significantly reduced total intra‐abdominal fat, which consists of the retroperitoneal fat mass and the epididymal fat mass. However, the exact mechanism by which 6‐OHDA reduced intra‐abdominal fat was unclear.…”

Section: Discussionmentioning

confidence: 99%

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An activated sympathetic nervous system affects white adipocyte differentiation and lipolysis in a rat model of Parkinson's disease

Meng

Zheng

Zhang

et al. 2014

J of Neuroscience Research

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Weight loss is an important nonmotor symptom associated with Parkinson's disease (PD). However, the cellular factors responsible for PD-induced weight loss remain unclear. Because the sympathetic nervous system plays an important role in lipid metabolism and fat cell differentiation, this study investigates whether PD-induced changes to this system are associated with weight loss in a rat model of PD. Body weight and food intake were measured in control and PD-model rats. After 10 weeks, retroperitoneal white adipose tissues (RWAT) were removed and weighed. Markers of the sympathetic nervous system were measured in the brainstem dorsal medulla and RWAT. Free fat acids (FFA), triglycerides (TG), adipocyte differentiation-related genes, and lipolysis-related molecules in the RWAT and serum were analyzed. Differences in body weight and food intake were insignificant in PD-model rats and control rats; however, relative RWAT weight and adipocyte surface area were significantly reduced in the PD group. Changes in markers of the sympathetic nervous system were observed in the brainstem dorsal medulla and RWAT of PD rats. Decreased mRNA expression levels of genes involved in adipocyte differentiation, decreased TG levels in RWAT, increased FFA in RWAT, and increased lipolysis-related molecules in RWAT and serum FFA were observed in PD rats. This study demonstrates that degenerated dopaminergic neurons in the nigrostriatal system correlate with increases in sympathetic nervous system function, resulting in lipolysis and inhibition of fat cell differentiation. These factors ultimately result in the decrease of RWAT in PD-model rats.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

An activated sympathetic nervous system affects white adipocyte differentiation and lipolysis in a rat model of Parkinson's disease

Meng

Zheng

Zhang

et al. 2014

J of Neuroscience Research

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“…On this topic there was demonstrated insulin immunoreactivity disturbances in PD patients compared to controls [49]. The evidence that insulin low levels lead to a reduction in lipogenesis more than food digestion and absorption [50], reinforce the relationship of loss of fat mass, insulin resistance and DP [14,51,52].…”

Section: Glycemia Insulin Resistance and Parkinson's Diseasementioning

confidence: 82%

Effects of Metabolic Syndrome on Parkinson’s Disease and Nutraceutical Intervention Strategies

Komuro¹,

Santos²,

Schelp³

et al. 2023

Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials

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Hyperglycemia, insulin resistance disturbances, and other common metabolic syndrome signs are currently related to a poor outcome of Parkinson disease. There were no widely accepted nutritional intervention protocols approved for Parkinson’s disease. That author exposes a brief revision of the role of insulin resistance and glycemic metabolism dysfunction in Parkinson’s patients with diabetes. In an ongoing study, with a complete record of dietary habits and diet components, it was demonstrated no significant differences between diabetics (n = 19) and nondiabetics (N = 53). But body composition shows some particularities. A result that attracts attention is total fat analysis and percentage of fat of PD patients showing that diabetics are somewhat fattier. The self-reported presence of obesity does not differ from recorded data of weight and BMI, with no significant differences between the two groups. Taking into consideration that both groups have comparable degrees of disease progression, as measured by the UPDRS, it could be possible to infer that the maintenance of a relative overweight was a protective factor in this group of diabetic evaluated patients. Considerations are made about hasty intervention of nutritional approach for PD patients with diabetes, including body fat reduction, prescription of statins and therapeutic options for diabetes control.

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“…So, it was very interesting to study the ongoing pathologic processes during the latent phase, which according to literature are based on changes of amount of free radical processes [22] [23]. These neurodegenerative processes lead to the disturbance of the respiratory chain in the mitochondria of the brain [24]- [27].…”

Section: Discussionmentioning

confidence: 99%

Study of Free-Radical Processes during Rotenone Modeling of Parkinson Disease

Ghazaryan¹,

Ghulikyan²,

Chavushyan³

et al. 2016

JBPC

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The study has shown free radical processes during modeling of Parkinson Disease (PD) with rotenone. We isolated striatum, brainstem, neocortex, cerebellum, spinal cord, thymus, heart, and liver of rats after rotenone injection in the right striatum. The samples were taken on the 5th, 10th and 15th days after the injection. According to chemiluminescence data, the injection of rotenone initiates the disturbance of intensity of free radical processes in striatum at 5th day in a bilateral mode. After this until the 10th day these changes had restoring character, but after 15 days according to chemiluminescence and thio-barbituric acid test disturbance of lipid peroxide oxidation processes occurred. While superoxide dismutase activity has been changed significantly in all studied tissues, especially in the striatum and neocortex. It should be noted that during rotenone model there are no observed clinical symptoms in rats during 1 to 20 days, and the symptoms of the disease are observed approximately 28 days after the injection. This research could help diagnose PD in the early stage of its onset.

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Possible regulatory factors for intra-abdominal fat mass in a rat model of Parkinson's disease

Cited by 11 publications

References 21 publications

An activated sympathetic nervous system affects white adipocyte differentiation and lipolysis in a rat model of Parkinson's disease

An activated sympathetic nervous system affects white adipocyte differentiation and lipolysis in a rat model of Parkinson's disease

Effects of Metabolic Syndrome on Parkinson’s Disease and Nutraceutical Intervention Strategies

Study of Free-Radical Processes during Rotenone Modeling of Parkinson Disease

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