Possible relationship between electroencephalogram finding and lithium response in bipolar disorder

Ikeda, Akifumi; Kato, Nobuo; Kato, Takeshi

doi:10.1016/s0278-5846(02)00203-8

Cited by 21 publications

(20 citation statements)

References 31 publications

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“…Cook et al 1986;Dewan et al 1988;Gerez and Tello 1992;Kano et al 1992;Koles et al 1994;Souza et al 1995;Small et al 1989Small et al , 1998Schulz et al 2000;El-Badri et al 2001;Ikeda et al 2002). The present study differs from other studies since none of the other groups analyzed the spontaneous EEG jointly with visual evoked oscillations in groups of drug-free euthymic patients.…”

Section: Electrophysiology In Bipolar Disorder Especially In Alpha Omentioning

confidence: 60%

Brain’s alpha activity is highly reduced in euthymic bipolar disorder patients

et al. 2011

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Brain's alpha activity and alpha responses belong to major electrical signals that are related to sensory/cognitive signal processing. The present study aims to analyze the spontaneous alpha activity and visual evoked alpha response in drug free euthymic bipolar patients. Eighteen DSM-IV euthymic bipolar patients (bipolar I n = 15, bipolar II n = 3) and 18 healthy controls were enrolled in the study. Patients needed to be euthymic at least for 4 weeks and psychotrop free for at least 2 weeks. Spontaneous EEG (4 min eyes closed, 4 min eyes open) and evoked alpha response upon application of simple visual stimuli were analyzed. EEG was recorded at 30 positions. The digital FFT-based power spectrum analysis was performed for spontaneous eyes closed and eyes open conditions and the response power spectrum was also analyzed for simple visual stimuli. In the analysis of spontaneous EEG, the ANOVA on alpha responses revealed significant results for groups (F(1,34) = 8.703; P < 0.007). Post-hoc comparisons showed that spontaneous EEG alpha power of healthy subjects was significantly higher than the spontaneous EEG alpha power of euthymic patients. Furthermore, visual evoked alpha power of healthy subjects was significantly higher than visual evoked alpha power of euthymic patients (F(1,34) = 4.981; P < 0.04). Decreased alpha activity in spontaneous EEG is an important pathological EEG finding in euthymic bipolar patients. Together with an evident decrease in evoked alpha responses, the findings may lead to a new pathway in search of biological correlates of cognitive impairment in bipolar disorder.

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Section: Electrophysiology In Bipolar Disorder Especially In Alpha Omentioning

confidence: 60%

Brain’s alpha activity is highly reduced in euthymic bipolar disorder patients

et al. 2011

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“…In this study none of five lithium responders had EEG abnormality, whereas all of five patients with EEG abnormality (three had epileptiform abnormalities and two had continuous abnormalities) were lithium nonresponders. These studies suggest that EEG abnormality is a possible predictor of lithium resistance in bipolar disorder (Ikeda et al 2002;Ikeda and Kato 2003).…”

Section: Lithiummentioning

confidence: 82%

Standard EEG: A Research Roadmap for Neuropsychiatry

Boutros¹

2013

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“…Of the 5 nonresponders, none had EEG abnormalities, whereas 3 of the 12 responders exhibited some form of EEG deviation (nature of deviation not specified). In the same vein, Ikeda et al (2002) examined the EEG predictive ability to lithium responsiveness in bipolar disorder. They examined 27 patients.…”

Section: Discussionmentioning

confidence: 99%

“…Because it is questionable whether IEDs are clinically silent, a therapeutic trial with AEDs might be justified. Consequently, AEDs are widely used in the treatment of a large variety of psychiatric disorders (Ikeda et al, 2002;McElroy et al, 1987McElroy et al, , 2002Stein et al, 1995) and a number of these disorders have increased the incidence of IEDs. It should be highlighted that the use of AEDs in treating psychiatric disorders is currently largely based on the belief that these agents possess psychotropic capabilities (Anagnostou et al, 2006).…”

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confidence: 99%

Predictive Value of Isolated Epileptiform Discharges for a Favorable Therapeutic Response to Antiepileptic Drugs in Nonepileptic Psychiatric Patients

Boutros

Kirollos

Pogarell

et al. 2014

Journal of Clinical Neurophysiology

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The efficacy of antiepileptic drugs (AEDs) in treating behavioral symptoms in nonepileptic psychiatric patients with abnormal EEGs is currently unknown. Although isolated epileptiform discharges have been reported in many psychiatric conditions, they are most commonly observed in patients with aggression, panic, or autistic spectrum disorders. The literature search was guided by 3 criteria: (1) studies had patients who did not experience seizures, (2) patients had EEGs, and (3) an AED was administered. Most important finding is that the number of "controlled" studies was extremely small. Overall, most reports suggest that the use of an AED can be associated with clinical and, at times, improved EEG abnormalities. Additionally, six controlled studies were found for other psychiatric disorders, such as learning disabilities with similar results. Overall, the use of anticonvulsants to treat nonepileptic psychiatric patients needs further controlled studies to better define indications, adequate EEG work-up, best AED to be used, and optimal durations of treatment attempts.

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Possible relationship between electroencephalogram finding and lithium response in bipolar disorder

Cited by 21 publications

References 31 publications

Brain’s alpha activity is highly reduced in euthymic bipolar disorder patients

Brain’s alpha activity is highly reduced in euthymic bipolar disorder patients

Standard EEG: A Research Roadmap for Neuropsychiatry

Predictive Value of Isolated Epileptiform Discharges for a Favorable Therapeutic Response to Antiepileptic Drugs in Nonepileptic Psychiatric Patients

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