1980
DOI: 10.1016/0021-9150(80)90006-4
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Possible relationship of cholesterol accumulation and collagen synthesis in rabbit aortic tissues

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1981
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Cited by 14 publications
(4 citation statements)
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“…However, increased aortic prolyl hydroxylase activity correlated well with cholesterol accumulated in aortic tissue. 3 A similar correlation may well exist with this parameter, a possibility which is under continued investigation.…”
mentioning
confidence: 70%
See 1 more Smart Citation
“…However, increased aortic prolyl hydroxylase activity correlated well with cholesterol accumulated in aortic tissue. 3 A similar correlation may well exist with this parameter, a possibility which is under continued investigation.…”
mentioning
confidence: 70%
“…1 It has been suggested that the presence of the fibrous cap tends to retard or prevent regression of the lesion if the atherogenic diet is withdrawn from experimental animals, 2 possibly because of the retention of increased aortic cholesterol by the excess connective tissue protein content. 3 The accumulation of connective tissue proteins appears to be influenced by the specific nature of the atherogenic diet, since a diet containing 2% cholesterol further supplemented with 8% peanut oil induces lesions that are more fibrotic than a diet containing only high levels of cholesterol. 4 ' 5 Such alterations in the content and metabolism of collagen and elastin may be critical to the development and irreversibility of atherosclerotic lesions since these proteins can serve as lipid-binding sites.…”
mentioning
confidence: 99%
“…These changes include the fragmentation of elastin fibers and deposition and cross-linking of collagen. 40 These alterations in the ECM increase the migration and proliferation of smooth muscle cells, 41 thrombosis, 42 expression of vascular adhesion molecules, 43 endothelial permeability, 44 cholesterol deposition, 45 and atherosclerotic plaque severity. 46 Although not all of these changes have been directly associated with adverse cardiac events, these mechanisms may underlie the link between arterial stiffness, atherogenesis, and atherosclerotic plaque instability, which may mediate the increased risk of adverse cardiovascular events observed in this study.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, Langner (1976b) demonstrated that continuous cholesterol feeding will by itself stimulate tissue collagen formation. They suggested that if the rabbits could survive eating a 2% cholesterol diet for 10 months, they would also develop a fibrous type of lesion, and in a recent publication (Modrak & Langner, 1980) questioned the exact role that collagen plays in the pathogenesis of atherosclerosis.…”
Section: Pathologymentioning
confidence: 99%