Possible Role of Adrenomedullin In the Pathogenesis of Tubal Ectopic Pregnancy

Liao, Song-Yan; Li, H. W. R.; Ho, J. C.; Yeung, William S.B.; Ng, Ernest Hung Yu; Cheung, Annie N.Y.; Tang, Florence

doi:10.1210/jc.2011-3290

Cited by 26 publications

(22 citation statements)

References 20 publications

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“…Stimulating effects of ADM is blocked by the calcitonin-gene-related peptide (CGRP) receptor antagonist [53]. In line with these studies, it has been suggested that plasma and tubal levels of ADM are lower in patients with tubal ectopic pregnancy compared to those with a normal pregnancy [54].…”

Section: Adrenomedullinmentioning

confidence: 95%

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Ezzati

Djahanbakhch

Arian³

et al. 2014

J Assist Reprod Genet

106

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With the advent of assisted reproductive technology in the past three decades, the clinical importance of fallopian tubes has been relatively overlooked. However, successful spontaneous conception requires normal function of the tube to provide not only a conduit for the gametes to convene and embryo to reach the uterine cavity, but also a physiologically optimized environment for fertilization and early embryonic development. In this review, after a brief description of normal human tubal anatomy and histology, we will discuss tubal transport and its principal effectors, including ciliary motion, muscular contractility and tubal fluid. Furthermore, we will discuss the ciliary ultrastructure and regulation of ciliary beat frequency by ovarian steroids, follicular fluid, angiotensin system, autonomic nervous system and other factors such as adrenomedullin and prostaglandins. In the last section, we describe the adverse impact of various pathological conditions, such as endometriosis, infection and smoking on tubal function and ciliary motility.

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Section: Adrenomedullinmentioning

confidence: 95%

Tubal transport of gametes and embryos: a review of physiology and pathophysiology

Ezzati

Djahanbakhch

Arian³

et al. 2014

J Assist Reprod Genet

106

View full text Add to dashboard Cite

show abstract

“…Indeed, recent studies showed that plasma and oviductal tissue ADM levels in patients with tubal ectopic pregnancy are lower than those from patients with normal pregnancy. Importantly, both ciliary beat frequency and frequency of muscle contraction of oviducts from patients with tubal ectopic pregnancy were found to be significantly lower than those from normal pregnancy [157]. Therefore, a low ADM level in the oviduct may lead to the retention and implantation of embryos in the oviduct in tubal ectopic pregnancies as a result of decreased ciliary beating and muscle contraction.…”

Section: The Role Of Clr/ramp Receptor Signaling In the Oviductmentioning

confidence: 99%

“…Therefore, a low ADM level in the oviduct may lead to the retention and implantation of embryos in the oviduct in tubal ectopic pregnancies as a result of decreased ciliary beating and muscle contraction. Thus, the plasma ADM level may be a useful biomarker for the prediction of tubal ectopic pregnancy [157]. …”

Section: The Role Of Clr/ramp Receptor Signaling In the Oviductmentioning

confidence: 99%

Roles of CLR/RAMP Receptor Signaling in Reproduction and Development

Chang¹,

Hsu

2013

CPPS

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Adrenomedullin (ADM), calcitonin gene-related peptides (α- and β-CGRPs), and intermedin/adrenomedullin 2 (IMD/ADM2) are major regulators of vascular tone and cardiovascular development in vertebrates. Recent research into their functions in reproduction has illuminated the role of these peptides and their cognate receptors (calcitonin receptor-like receptor/receptor activity-modifying protein (CLR/RAMP) receptors) in fetal–maternal blood circulation, feto-placental development, female gamete development, and gamete movement in the oviduct. Although ADM family peptides function in a temporally and spatially specific manner in various reproductive processes, they appear to act via a similar set of second messengers, including nitric oxide, cyclic GMP, cyclic AMP, and calcium-activated potassium channels in different tissues. These discoveries supported the view that CLR/RAMP receptors were recruited to perform a variety of newly evolved reproductive functions during the evolution of internal reproduction in mammals. These advances also provided insight into how CLR/RAMP receptor signaling pathways coordinate with other physiological adaptions to accommodate the extra metabolic needs during pregnancy, and captured some important details as to how fetal–maternal vascular communications are generated in the first place. Furthermore, these findings have revealed novel, promising opportunities for the prevention and treatment of aberrant pregnancies such as pregnancy-induced hypertension, preeclampsia, and tubal ectopic pregnancy. However, significant efforts are still needed to clarify the relationships between certain components of the CLR/RAMP signaling pathway and aberrant pregnancies before CLR/RAMP receptors can become targets for clinical management. With this understanding, this review summarizes recent progresses with particular focus on clinical implications.

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“…Adrenomedullin is a peptide hormone belonging to calcitonin/calcitonin gene related peptide, and is thought be involved in endometrial angiogenesis. Liao et al found plasma and oviductal tissue adrenomedullin to be lower in EP and suggested that this decreases ciliary beating and muscle contraction leading to retained embryo and its implantation in the oviduct [99]. Similar findings were observed in nasal epithelium in patients of tEP by the same group [100].…”

Section: Adrenomedullinmentioning

confidence: 66%