Possible role of diet in cancer: systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk

Grosso, Giuseppe; Bella, Francesca; Godos, Justyna; Sciacca, Salvatore; Rio, Daniele Del; Ray, Sumantra; Galvano, Fabio; Giovannucci, Edward

doi:10.1093/nutrit/nux012

Cited by 369 publications

(285 citation statements)

References 113 publications

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“…These results show that ultra-processed food consumption and overweight were associated with breast cancer in this sample of Brazilian women, which is partially consistent with published studies [5,7,21,22]. Additionally, poor environmental sanitation and family history of cancer were identified as risk factors for breast cancer in these women.…”

Section: Discussionsupporting

confidence: 91%

“…The etiology of breast cancer is still poorly understood and the known risk factors only explain a small proportion of cases. It is known that cancer is the result of an interaction between endogenous and environmental factors, and dietary habits are among them [4,5]. Among the factors documented for the increase in breast cancer incidence, hereditary factors (genetic and family history) and some environmental factors standout, such as poor eating habits (for example, low consumption of fruit and high consumption of ultra-processed foods), physical inactivity, exposure to smoking and alcohol intake [6,7].…”

Section: Introductionmentioning

confidence: 99%

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Nutritional and environmental risk factors for breast cancer: a case-control study

Queiroz¹,

Sousa²,

Silva³

et al. 2018

Sci Med

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Nutritional and environmental risk factors for breast cancer: a case-control study

Queiroz¹,

Sousa²,

Silva³

et al. 2018

Sci Med

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“…Foods contain both compounds that are protective and others that may cause harm and have an oncogenic effect [71]. We can consider the impact of individual nutrients (e.g., carbohydrates, saturated fat), important dietary markers (e.g., glycemic index, insulin load), and overall dietary patterns (e.g., high-fat versus plant-based diets) on one’s risk of developing breast cancer.…”

Section: Dietary Factors and Nutrition In Breast Cancer Riskmentioning

confidence: 99%

“…This, in turn, increases one’s risk of the developing breast cancer [71, 132]. Red and processed meat, butter, saturated and trans-fats, alcohol, nitrosamines, diets low in omega-3 fatty acids, sugar, and Western dietary patterns are associated with increased levels of CRP and pro-inflammatory cytokines and have been identified as ingredients that may increase the risk of different types of cancer, including breast [91, 133].…”

Section: Dietary Factors and Nutrition In Breast Cancer Riskmentioning

confidence: 99%

Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

Seiler

Chen

Brown

et al. 2018

Curr Breast Cancer Rep

100

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Purpose of Review To synthesize the critical role of obesity-associated inflammation, dietary factors, and nutrition in determining breast cancer risk. Recent Findings Obesity-associated inflammation is strongly linked to breast cancer risk and progression, largely via two processes: inflammatory pathways and dysregulated metabolism. Cytokine production in excess adipose tissues creates a chronic inflammatory microenvironment, which favors tumor development. Lifestyle factors, including diet, have long been recognized as important determinants of breast cancer risk and mortality. Summary Obesity increases the risk of developing breast cancer in both pre- and postmenopausal women and also negatively affects breast cancer recurrence and survival. Poor dietary habits characterized by the high intake of refined starches, sugar, and both saturated and trans-saturated fats, as well as the low intake of omega-3 fatty acids, natural antioxidants, and fiber, modulate inflammation and, thereby, appear to be linked to increased risk of breast cancer and mortality.

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“…Khera et al [25], Stonerock and Blumenthal [26], and Johal et al [27] proposed that maintaining a healthy lifestyle is beneficial for preventing cardiovascular disease and reducing its incidence. In addition, living a healthy life has a substantial effect on decreasing the risk of cancer [28,29]. Nevertheless, when physicians suggest that patients make major changes in lifestyle, the patients are unlikely to comply [26].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Internet Health Information and Patient Compliance Based on Trust: Empirical Study

Zhang

et al. 2018

J Med Internet Res

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BackgroundThe internet has become a major mean for acquiring health information; however, Web-based health information is of mixed quality and may markedly affect patients’ health-related behavior and decisions. According to the social information processing theory, patients’ trust in their physicians may potentially change due to patients’ health-information-seeking behavior. Therefore, it is important to identify the relationship between internet health information and patient compliance from the perspective of trust.ObjectiveThe objective of our study was to investigate the effects of the quality and source of internet health information on patient compliance using an empirical study based on the social information processing theory and social exchange theory.MethodsA Web-based survey involving 336 valid participants was conducted in China. The study included independent variables (internet health information quality and source of information), 2 mediators (cognition-based trust [CBT] and affect-based trust [ABT]), 1 dependent variable (patient compliance), and 3 control variables (gender, age, and job). All variables were measured using multiple-item scales from previously validated instruments, and confirmative factor analysis as well as structural equation modeling was used to test hypotheses.ResultsThe questionnaire response rate was 77.16% (375/486), validity rate was 89.6% (336/375), and reliability and validity were acceptable. We found that the quality and source of internet health information affect patient compliance through the mediation of CBT and ABT. In addition, internet health information quality has a stronger influence on patient compliance than the source of information. However, CBT does not have any direct effect on patient compliance, but it directly affects ABT and then indirectly impacts patient compliance. Therefore, the effect of ABT seems stronger than that of CBT. We found an unexpected, nonsignificant relationship between the source of internet health information and ABT.ConclusionsFrom patients’ perspective, internet health information quality plays a stronger role than its source in impacting their trust in physicians and the consequent compliance with physicians. Therefore, patient compliance can be improved by strengthening the management of internet health information quality. The study findings also suggest that physicians should focus on obtaining health information from health websites, thereby expanding their understanding of patients’ Web-based health-information-seeking preferences, and enriching their knowledge structure to show their specialization and reliability in the communication with patients. In addition, the mutual demonstration of care and respect in the communication between physicians and patients is important in promoting patients’ ABT in their physicians.

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Possible role of diet in cancer: systematic review and multiple meta-analyses of dietary patterns, lifestyle factors, and cancer risk

Abstract: The results suggest a potential role of diet in certain cancers, but the evidence is not conclusive and may be driven or mediated by lifestyle factors.

Cited by 369 publications

References 113 publications

Nutritional and environmental risk factors for breast cancer: a case-control study

Nutritional and environmental risk factors for breast cancer: a case-control study

Obesity, Dietary Factors, Nutrition, and Breast Cancer Risk

Relationship Between Internet Health Information and Patient Compliance Based on Trust: Empirical Study

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