possible role of high risk HPV infection and RPD3 overexpression in Iraqi patients with colorectal cancer

Abstract

Aims: the aim of this study is RPD3 expression in clinicopathological characteristics in CRC patients and to study the existence of a relationship between CRC and HPV in samples of Iraqi patients. Material and methods: 30 samples of formalin-fixed, paraffin-embedded archival tissues from CRC patients were obtained, together with 10 samples of normal tissue (free cancer), for immunohistochemical analysis of RPD3 and HPV expression. Results: Immunohistochemical (IHC) staining revealed only four cases (15%) with HPV infections while PRD3 was expressed in 19 CRC samples (63.3 percent). The PRD3 expression ratio. It was found in only four (15%) of the CRC samples. At ≤ P 0. 05, there is no significant difference. Conclusion: The results of this study support RPD3 as a supplementary marker to identified histologic screening components; it could possibly be used for the prognosis and targeted therapy. In addition, we discovered a relation with both HPV infection and CRC as oncovirus and tumorigenic factor.