Possible role of milk-derived bioactive peptides in the treatment and prevention of metabolic syndrome

Abstract

The growing prevalence of metabolic syndrome as well as its impact on public health has garnered increased attention in recent years. As a result, metabolic syndrome is now considered one of the world's leading public health problems. Bioactive peptides deriving from milk proteins may play an important role in the prevention and treatment of metabolic syndrome and its complications via several mechanisms, such as the satiety response, the regulation of insulinemia levels and blood pressure, the uptake of free radicals, and alteration of the lipid profile. These peptides can be incorporated into functional foods or administered via nutraceuticals to decrease the risk of obesity, atherogenesis, arterial hypertension, and type 2 diabetes. Recent findings have generated considerable scientific and commercial interest in milk-derived bioactive peptides, leading to numerous publications on the effectiveness of these substances. This review summarizes the current knowledge on bioactive peptides derived from milk proteins and examines the potential value of these peptides in the treatment and prevention of metabolic syndrome and its complications.

Intake of milk, but not total dairy, yogurt, or cheese, is negatively associated with the clustering of cardiometabolic risk factors in adolescents

“…Furthermore, the lack of association observed between CMRS and cheese may be, in part, explained by the higher fat, sodium, and lower potassium held by cheese compared with milk and other fluid dairy food [38]. On the other hand, the preponderance of evidence, mostly in adults, indicates that milk intake is more likely to be associated with beneficial cardiometabolic outcomes [13], [39], [40] and [41]. Few studies have shown the beneficial effects of other dairy products [10], [36] and [42].…”

“…Emerging scientific findings also indicate that such milk fat components as butyric acid may favor fat oxidation and decrease glycogen use [50]. Moreover, it seems that bioactive peptides derived from milk proteins may act independently of calcium to prevent the development of cardiometabolic risk factors and its components via a wide range of mechanisms that include the satiety response, the regulation of insulinemia levels and BP, the uptake of free radicals, and the alteration of lipid profiles [13].…”

“…Evidence, mostly in adults, has indicated that increased dairy intake may decrease the risk of high blood pressure (BP) [8] and [9], central obesity [10] and [11], and hyperinsulinemia [12]. It has been established that such dairy components as calcium, medium-chain fatty acids, and bioactive peptides may play an important role in the prevention of cardiometabolic risk and its complications via the exertion of mechanisms that include the satiety response and the regulation of insulinemia levels and BP [13].…”

Effect of ewe’s (semi-skimmed and whole) and cow’s milk yogurt consumption on the lipid profile of control subjects: a crossover study

“…The protein content in yogurts made from cow’s and ewe’s milk is also different, as it is related to whey proteins and to the profile of bioactive peptides with the beneficial effects of these products [72,73]. The hypocholesterolaemic effect of whey proteins has been observed in connection with casein in an intervention study [74].…”

Más allá del valor nutricional del yogur, ¿un indicador de calidad de la dieta?

“…Durante los últimos años, los péptidos que forman parte del yogur han sido de gran interés a nivel científico por sus propiedades antihipertensivas, antimicrobianas, inmunomoduladoras, hipolipemiantes y una importante relación sobre la prevención de acumulación de grasa a nivel central (11).…”