Possible Role of Nerve Growth Factor in the Pathogenesis of Alcohol Dependence

Yoon, Sujung; Roh, Sungwon; Lee, Heejin; Lee, Ji Youl; Lee, Bun Hee; Kim, Yong Ku; Kim, Daijin

doi:10.1111/j.1530-0277.2006.00120.x

Cited by 26 publications

(16 citation statements)

References 47 publications

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“…Furthermore, our results show a decreased serum NGF levels in the alcohol-dependent patients when compared to the healthy controls. Decreased plasma NGF concentrations in alcohol-dependent patients have been found before [23]. Our finding of a NGF decrease during alcohol withdrawal is in line with previous data on NGF plasma levels in alcohol-dependent patients showing a significant NGF plasma levels decrease from day 0 to day 7 during alcohol withdrawal [24].…”

Section: Discussionsupporting

confidence: 82%

“…After chronic exposure to ethanol, a decrease of NGF had been observed in rats [22] and plasma. NGF concentrations in alcohol-dependent patients are significantly lower than in healthy controls [23]. Recently, Lee et al [18] demonstrated that the mean plasma NGF level was significantly higher in patients with alcohol dependence than in healthy subjects.…”

Section: Introductionmentioning

confidence: 99%

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Serum Brain-Derived Neurotrophic Factor and Nerve Growth Factor Concentrations Change after Alcohol Withdrawal: Preliminary Data of a Case-Control Comparison

et al. 2012

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Background: Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are involved in neuroadaptation and foster survival of central and peripheral neurons. In this study, we addressed the question whether BDNF and NGF serum concentrations change during subacute alcohol withdrawal in patients with alcohol dependence compared to healthy controls. Methods: Fifteen patients (age 48.6 ± 7 years) and 15 healthy age-matched controls (age 48.8 ± 7 years) participated consecutively in a 2-week withdrawal study. Results: Mean BDNF levels (7.8 ng/ml, IQR = 4.4–10.7 vs. 16.5 ng/ml, IQR = 13.9–25.6; Z = –3.8, p < 0.0001) and NGF levels (5.8 pg/ml, IQR = 3.8–13.0 vs. 18.4 pg/ml, IQR = 10.9–25.1; Z = –2.5, p = 0.012) were significantly decreased in alcohol-dependent subjects when compared to healthy matched controls. NGF concentrations decreased significantly from day 3 to day 14 (Z = –2.36; p = 0.019). Mean BDNF concentrations showed a tendency to increase after withdrawal from day 3 to day 14 (Z = 1.7; p = 0.078). Conclusion: Decreased NGF and BDNF concentrations in patients suffering from alcohol dependence, which stabilize after physical withdrawal, are in line with withdrawal symptoms and neurological risk factors. In turn, increase of BDNF after acute withdrawal might be connected to neurobiological and behavioral stabilization.

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Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Serum Brain-Derived Neurotrophic Factor and Nerve Growth Factor Concentrations Change after Alcohol Withdrawal: Preliminary Data of a Case-Control Comparison

et al. 2012

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“…The neurotrophic factor nerve growth factor was reported to be involved in the pathogenesis of alcohol dependence (Yoon et al, 2006). Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophic factors in the brain (Chao, 2003), and it may be involved in the development of alcohol dependence.…”

mentioning

confidence: 99%

Decreased Plasma Brain‐Derived Neurotrophic Factor Levels in Patients With Alcohol Dependence

Joe

Kim

et al. 2007

Alcoholism Clin & Exp Res

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118

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“…Indeed, authors discussed that withdrawal from chronic alcohol consumption may elicit significant stress and related anxiety triggering NGF blood release as previously observed for other stressing conditions [11,17]. However, other data showed lowered NGF levels in alcohol-dependent patients [26,49,50]. In one of these study alcoholics were abstinent for 30 days or longer to ruled out alcohol withdrawal effects such as anxiety [49].…”

Section: Discussionmentioning

confidence: 94%

“…In one of these study alcoholics were abstinent for 30 days or longer to ruled out alcohol withdrawal effects such as anxiety [49]. Thus it may be hypothesized that different circulating BDNF/NGF levels due to withdrawal or long-lasting abstinence or dependence or intoxication may reflect a trait marker of alcohol addiction rather than a state marker [26,28,49,51,52].…”

Section: Discussionmentioning

confidence: 99%

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

Carito¹

2015

J Alcohol Drug Depend

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Many studies have suggested possible relationships between the neurotrophins brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) and alcohol addiction. Previous reports demonstrated severe changes in these neurotrophins in the serum of alcohol dependent patients and during withdrawal. Alcohol dependence syndromes during consumption and/or withdrawal are also characterized by elevated oxidative stress. Polyphenols, including olive polyphenols, are natural compounds known to possess marked antioxidant properties. Thus, this study was carried out in order to verify the effects of a blend of olive polyphenols supplementation containing mostly hydroxytyrosol (50 mg/day for 15 consecutive days) in alcoholic men during withdrawal on serum BDNF and NGF. As controls a group of alcohol dependent patients received sucrose tablets as placebo. BDNF and NGF were measured by ELISA on day 1, 3, 7 and 15 of the detoxification period. Some parameters of oxidative stress were analyzed too as free oxygen radicals defense (FORD) and free oxygen radicals test (FORT). No differences in oxidative status due to polyphenols were found. However, withdrawal elicited a mild increase in BDNF over two weeks that was counteracted on day 3 by polyphenols. As for NGF no effects of polyphenols supplementation were discovered to antagonize the expected NGF serum elevation during withdrawal. In conclusion the present data may indicate that monitoring serum BDNF and/or NGF in alcoholics undergoing detoxification could contribute to characterize alcohol dependence profiles to improve recovery processes throughout also antioxidant compounds.

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Possible Role of Nerve Growth Factor in the Pathogenesis of Alcohol Dependence

Abstract: Our study suggests that the NGF levels may be a trait marker for the development of alcohol dependence.

Cited by 26 publications

References 47 publications

Serum Brain-Derived Neurotrophic Factor and Nerve Growth Factor Concentrations Change after Alcohol Withdrawal: Preliminary Data of a Case-Control Comparison

Serum Brain-Derived Neurotrophic Factor and Nerve Growth Factor Concentrations Change after Alcohol Withdrawal: Preliminary Data of a Case-Control Comparison

Decreased Plasma Brain‐Derived Neurotrophic Factor Levels in Patients With Alcohol Dependence

Serum BDNF and NGF Modulation by Olive Polyphenols in Alcoholics during Withdrawal

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