Possible role of serotoninergic system in the neurobehavioral impairment induced by acute methylmercury exposure in zebrafish (Danio rerio)

Maximino, Caio; Araújo, Juliana Baldan Costa Neves; Leão, Luana Ketlen Reis; Grisólia, Alan Barroso Araújo; Oliveira, Karen Renata Matos; Lima, Mônica Gomes; Batista, Evander de Jesus Oliveira; Crespo-López, María Elena; Gouvêia, Amauri; Herculano, Anderson Manoel

doi:10.1016/j.ntt.2011.08.006

Cited by 68 publications

(42 citation statements)

References 63 publications

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“…For example, both reserpine and 3,4-methylenedioxy- N -methylamphetamine (MDMA) inhibit VMAT (Erickson et al 1992; Rudnick and Wall 1992), but unlike the lack of overt behavioral effects of acute reserpine here, MDMA increases top swimming in zebrafish (Stewart et al 2011d), similar to a serotonergic ligand lysergic acid diethylamide (LSD) or chronic fluoxetine (Grossman et al 2010; Egan et al 2009), a reuptake inhibitor that selectively blocks SERT. Collectively, this suggests that while an anxiolytic-like action in zebrafish is likely mediated via serotonergic mechanisms (Maximino and Herculano 2010; Maximino et al 2011), they do not seem to play a major role in the acute action of reserpine.…”

Section: Discussionmentioning

confidence: 97%

Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish

Kyzar¹,

Stewart

Landsman³

et al. 2013

Brain Research

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Brain monoamines play a key role in the regulation of behavior. Reserpine depletes monoamines, and causes depression and hypoactivity in humans and rodents. In contrast, d-amphetamine increases brain monoamines’ levels, and evokes hyperactivity and anxiety. However, the effects of these agents on behavior and in relation to monoamine levels remain poorly understood, necessitating further experimental studies to understand their psychotropic action. Zebrafish (Danio rerio) are rapidly emerging as a promising model organism for drug screening and translational neuroscience research. Here, we have examined the acute and long-term effects of reserpine and d-amphetamine on zebrafish behavior in the novel tank test. Overall, d-amphetamine (5 and 10 mg/L) evokes anxiogenic-like effects in zebrafish acutely, but not 7 days later. In contrast, reserpine (20 and 40 mg/L) did not evoke overt acute behavioral effects, but markedly reduced activity 7 days later, resembling motor retardation observed in depression and/or Parkinson’s disease. Three-dimensional ‘temporal’ (X, Y, Time) reconstructions of zebrafish locomotion further supports these findings, confirming the utility of 3D-based video-tracking analyses in zebrafish models of drug action. Our results show that zebrafish are highly sensitive to drugs bi-directionally modulating brain monoamines, generally paralleling rodent and clinical findings. Collectively, this emphasizes the potential of zebrafish tests to model complex brain disorders associated with monoamine dysregulation.

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Section: Discussionmentioning

confidence: 97%

Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish

Kyzar¹,

Stewart

Landsman³

et al. 2013

Brain Research

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“…In humans, chronic subtoxic levels of inorganic mercury produced heightened distress, anxiety and psychoticism without alterations in general intellectual functioning and motor skills [133]. In studies using zebrafish, Maximino et al have proposed that oxidative stress induced by methylmercury produces mitochondrial dysfunction and inhibits tryptophan hydroxylase, thereby altering serotoninergic systems [134]. …”

Section: Other Metalsmentioning

confidence: 99%

Iron and mechanisms of emotional behavior

Kim

Wessling‐Resnick

2014

The Journal of Nutritional Biochemistry

227

138

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Iron is required for appropriate behavioral organization. Iron deficiency results in poor brain myelination and impaired monoamine metabolism. Glutamate and GABA homeostasis is modified by changes in brain iron status. Such changes not only produce deficits in memory/learning capacity and motor skills, but also emotional and psychological problems. An accumulating body of evidence indicates that both energy metabolism and neurotransmitter homeostasis influence emotional behavior, and both functions are influenced by brain iron status. Like other neurobehavioral aspects, the influence of iron metabolism on mechanisms of emotional behavior are multifactorial: brain region-specific control of behavior, regulation of neurotransmitters and associated proteins, temporal and regional differences in iron requirements, oxidative stress responses to excess iron, sex differences in metabolism, and interactions between iron and other metals. To better understand the role that brain iron plays in emotional behavior and mental health, this review discusses the pathologies associated with anxiety and other emotional disorders with respect to body iron status.

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“…In the glass eel, MeHg concentration values ranged from 61 to 682 ng Hg g −1 dw (0.014 to 0.068 μg Hg g −1 ww) which is consistent with those found by Navarro et al (2013) in the same estuary. MeHg is known for its high toxicity in fish, affecting morphology (Samson and Shenker 2000), physiology (Sarnowski 2003) and behavioural patterns such as swimming activity (Maximino et al 2011). Laboratory experiments have demonstrated that embryonic exposure to MeHg causes behavioural changes in larval fish, Marine station R²=0,31 Estuarine station R²=0,33 [MeHg] ng Hg g -1 dw…”

Section: Migratory Behaviour and Mehg Concentrations In Glass Eelsmentioning

confidence: 99%

Spatial and seasonal variations of methylmercury in European glass eels (Anguilla anguilla) in the Adour estuary (France) and relation to their migratory behaviour

Claveau

Monperrus

Jarry

et al. 2015

Environ Sci Pollut Res

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Overall recruitment of European glass eels (Anguilla anguilla) has decreased significantly since the early 1980s. Due to their long life cycle, benthic/demersal habits and high lipid content, eels might accumulate high concentrations of contaminants, but data concerning glass eels are still scarce. This study provides original data on methylmercury (MeHg) concentrations in glass eels at spatial (marine and estuarine), annual and seasonal scales. The relationship between MeHg concentrations in glass eels and their propensity to migrate up estuaries was also investigated. MeHg data were individually related to the eels' energetic condition which was estimated by dry weight. Glass eel migratory behaviour was investigated in an experimental flume and related to the MeHg concentration and dry weight at the individual scale. Marine and estuarine glass eels were caught from 2004 to 2011. There was a strong inverse correlation between MeHg concentrations and dry weight. MeHg concentrations increased in marine and estuarine glass eels from 2004 to 2009 and from 2004 to 2010, respectively, and then, both groups decreased in 2011. On a seasonal time scale, MeHg concentrations were higher at the end of the fishing season (April). MeHg bioaccumulation is likely to result from different sources, but the lack of significant differences between marine and estuarine glass eels suggests that direct contamination during estuarine migration is low. Other sources such as maternal transfer or oceanic contamination are discussed.

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Possible role of serotoninergic system in the neurobehavioral impairment induced by acute methylmercury exposure in zebrafish (Danio rerio)

Cited by 68 publications

References 63 publications

Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish

Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish

Iron and mechanisms of emotional behavior

Spatial and seasonal variations of methylmercury in European glass eels (Anguilla anguilla) in the Adour estuary (France) and relation to their migratory behaviour

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