1990
DOI: 10.1016/0014-2999(90)94422-t
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Possible role of the endogenous kallikrein-kinin system in suppression of doca-salt-induced hypertension in rats

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Cited by 2 publications
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“…Both systems operate independently in vitro and in vivo (Uchida & Katori, 1985;Katori et al, 1988;1989;Majima et al, 1990). The plasma kallikrein-HMW kininogen system is activated via the activation of factor XII (Hageman factor) and activated plasma prekallikrein (plasma kallikrein) can release bradykinin from its substrate, HMW-kininogen.…”
Section: Discussionmentioning
confidence: 99%
“…Both systems operate independently in vitro and in vivo (Uchida & Katori, 1985;Katori et al, 1988;1989;Majima et al, 1990). The plasma kallikrein-HMW kininogen system is activated via the activation of factor XII (Hageman factor) and activated plasma prekallikrein (plasma kallikrein) can release bradykinin from its substrate, HMW-kininogen.…”
Section: Discussionmentioning
confidence: 99%
“…Deficient BN-Ka rats that cannot generate kinin in urine excreted less sodium and water in urine under a mild dietary NaCI loading or subcutaneous infusion of a nonpressor dose of angiotensin II. Hence, sodium was accumulated in the cerebrospinal fluid and erythrocytes, causing an elevation in blood pressure (1)(2)(3)(4)(5)(6). During the treatment of rats with sodium loading or angiotensin II infusion, supplementation of LMW kininogen to deficient BN-Ka rats reduced the systemic blood pressure with increased excretion of urinary kinin, urinary sodium and urine volume, whereas subcutaneous infusion of a bradykinin B2 receptor antagonist, Hoe 140, increased the blood pressure with reduced excretion of urinary sodium and urine volume, indicating direct linkage between kinin release, sodium excretion and high blood pressure.…”
Section: Discussionmentioning
confidence: 99%
“…Deficient BN-Ka rats (Rattus norvegicus, BN/fMai) were initially obtained from the Katholiek Universiteit of Leuven, Belgium, and they were fed in our animal facilities (1)(2)(3)(4)(5). Normal rats from the same strain were already being kept in Kitasato University (BN-Ki rats).…”
Section: Animalsmentioning
confidence: 99%
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