Possible Role of the Proximal Convoluted Tubules of Human Kidney in Chronic Glomerulonephritis

Abstract

The amount of forming pinocytic (coated) microvesicles on the apical plasma membrane of kidney proximal tubule cells was assessed in kidney biopsies of 10 patients suffering from chronic glomerulonephritis. A significant correlation was found between the amount of these vesicles and diurnal proteinuria levels (r =0.889; p < 0.01). The possible mechanisms of protein reabsorption via pinocytosis in both normal and pathological conditions are considered.

Nephrotic syndrome complicated by tubular dysfunction. Case report and review of possible mechanisms

“…Most of the childhood cases progressed rapidly to renal failure (McVicar, et al, 1974;Burke et al, 1971) and in these patients it seemed reasonable to explain tubular dysfunction as being secondary to gross renal damage and uraemia. Some authors have considered that this may always be the case; there is indeed a growing body of experimental evidence that in nephrotic syndrome with good renal function, both tubular function (Maddox et al, 1974;Andreucci et al, 1973;Oken and Flamenbaum, 1971) and morphology (Ryabov et al, 1978) are essentially normal and able to compensate appropriately for the changed intraluminal and peritubular environment. Sherman and Becker (1971) showed in 22 adult patients with nephrotic syndrome that glycosuria and lysozymuria were correlated with the degree of renal function rather than urinary or serum protein concentrations.…”

Membranous nephropathy in a Russian population

“…Вполне естественно между электронно-микроскопической, светооптической и иммуноморфологической оценками степени повреждения ГБМ прослеживаются отчетливые корреляции. По мере увеличения стадии ПМН отмечено закономерное прогрессирование выраженности фиброза интерстиция [35], связанное с известными «токсическими» тубулярными эффектами протеинурии [36][37][38][39][40]. Вместе с тем обращает внимание отсутствие параллелизма между объемом депозитов иммунных комплексов, содержащих IgG и C3, и степенью гломерулосклероза.…”