Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity

Kao, Joanna S; Dawson, Jeffrey D.; Murray, Jeffrey C.; Dagle, John M.; Berends, Susan K.; Gillen, Susan B; Bell, Edward F.

doi:10.1111/j.1651-2227.2010.02069.x

Cited by 28 publications

(24 citation statements)

References 28 publications

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“…25 Contrary to all of these reports; Heller et al 20 concluded that human breast milk intake was not associated with a decreased risk of ROP in extremely very low birth weight infants. Kao et al 22 also evaluated the antioxidant effect of human breast milk and bilirubin on ROP, but only high bilurubin levels were found to have a protective effect on ROP, contrary to our study. A common point to all of these studies including ours is that human breast milk is advised to prevent ROP.…”

Section: Volume 61 • Numbercontrasting

confidence: 99%

“…[1][2][3][4][5][6][7][13][14][15][16][17][18] The effect of human breast milk on ROP development is a controversial issue in the literature. [19][20][21][22][23][24][25] As far as we know, studies about the pathophysiological relationship between ROP and human breast milk are limited. 24 ROP develops at two phases and the first phase is the hyperoxic phase.…”

Section: Volume 61 • Numbermentioning

confidence: 99%

“…36,41 From a clinical aspect; the importance of human breast milk for ROP development has been previously reported. [19][20][21][22][23][24][25] A multicenter study evaluating the effect of human breast milk on ROP among other risk factors for 4 years, found that human breast milk prevents ROP. 23 Similar to this study, Hylander et al compared 283 formula and breast fed infants under 1500 grams and they concluded a lower incidence of ROP in breastfed infants.…”

Section: Volume 61 • Numbermentioning

confidence: 99%

“…The other independent factor which may be the only variable factor is breast feeding according to our clinical observations and related literature. [19][20][21][22][23][24][25] Human breast milk is indispensable for the maturation as it contains many immunogenic factors like epidermal growth factor (EGF), transforming growth factor (TGF) α, β1-2, ghrelin, lectin, adiponectin, erythropoietin and insulin-like growth factor-1(IGF-1). [26][27][28] In order to assess the effect of human milk and to revisit the risk factors related with ROP, the records of our patients were retrospectively analyzed.…”

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Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity?

Akyüz-Ünsal¹,

Key²,

Güler³

et al. 2019

Turk J Pediatr

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Akyüz-Ünsal Aİ, Key Ö, Güler D, Bekmez S, Sagus M, Akcan AB, Kurt-Omurlu İ, Anık A, Oruç-Dündar S, Türkmen M. Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity? Turk J Pediatr 2019; 61: 13-19.The aim of this study was to investigate the risk factors for Retinopathy of Prematurity (ROP) development and the potential effect of human breast milk among these factors. For this purpose, infants admitted to a tertiary referral clinic for ROP screening and treatment between April 2013 and May 2015, were included in this retrospective study. The demographic data, accompanying diseases, previous surgery, type of feeding and duration of human breast milk intake were recorded. According to the ROP screening examination results, infants were divided into two groups as those with ROP (infants at any stage of ROP) and those without ROP. Relationship between the risk factors and ROP were evaluated. The comparison of 221 infants without ROP and 99 infants with ROP; revealed that gestational age at birth, birth weight, mechanical ventilation support, bronchopulmonary and cardiac diseases, hydrocephaly, any previous surgery, infections, steroid treatment percentages were high and human breast milk intake percentage was low among infants with ROP. Mean breast feeding time for infants with ROP (3.81 ± 2.33 month) was shorter than the infants without ROP (5.51 ± 1.43 month) (p<0.001). In logistic regression analysis, the duration of breast feeding was inversely related with ROP (OR 0.744; 95% CI 0.621-0.891; p<0,001). These results suggest that gestational age at birth and accompanying diseases are the main risk factors for the development of ROP. As the duration of the breast feeding of the infants without ROP was longer than the infants with ROP; breast feeding may have a preventive effect on ROP development. : breast feeding, human breast milk, retinopathy of prematurity, risk factors, ROP. Key words

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Section: Volume 61 • Numbercontrasting

confidence: 99%

Section: Volume 61 • Numbermentioning

confidence: 99%

Section: Volume 61 • Numbermentioning

confidence: 99%

mentioning

confidence: 99%

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Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity?

Akyüz-Ünsal¹,

Key²,

Güler³

et al. 2019

Turk J Pediatr

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“…However, elevated circulating bilirubin concentrations have been associated with protection from neonatal hyperoxic exposure (and retinopathy of prematurity) in both rodent [13] and human [14] studies. Despite these findings, evidence to the contrary also exists and supports a popular debate in this area [15,16].…”

Section: Introductionmentioning

confidence: 99%

Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

Boon

Hawkins

Bisht

et al. 2012

Free Radical Biology and Medicine

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A protective association between bilirubin and atherosclerosis/ischemic heart disease clearly exists in vivo. However, the relationship between bilirubin and in vivo oxidative stress parameters in a clinical population remains poorly described. The aim of this study was to assess whether persons expressing Gilbert syndrome (GS; i.e., unconjugated hyperbilirubinemia) are protected from thiol oxidation and to determine if this, in addition to their improved lipoprotein profile, could explain reduced oxidized low-density lipoprotein (oxLDL) status in them. Forty-four matched GS and control subjects were recruited and blood was prepared for the analysis of lipid profile and multiple plasma antioxidants and measures of oxidative stress. GS subjects possessed elevated plasma reduced thiol (8.03±1.09 versus 6.75±1.39 nmol/mg protein; P <0.01) and glutathione concentrations (12.7±2.39 versus 9.44±2.45 μM; P <0.001). Oxidative stress status (reduced:oxidized glutathione; GSH:GSSG) was significantly improved in GS (0.49±0.16 versus 0.32±0.12; P <0.001). Protein carbonyl concentrations were negatively associated with bilirubin concentrations and were significantly lower in persons with >40 μM bilirubin versus controls (<17.1 μmol/L; P <0.05). Furthermore, absolute oxLDL concentrations were significantly lower in GS subjects ( P <0.05). Forward stepwise regression analysis revealed that bilirubin was associated with increased GSH:GSSG ratio and reduced thiol concentrations, which, in addition to reduced circulating LDL, probably decreased oxLDL concentrations within the cohort. In addition, a marked reduction in total cholesterol concentrations in hyperbilirubinemic Gunn rats is presented (Gunn 0.57±0.09 versus control 1.69±0.40 mmol/L; P <0.001), arguing for a novel role for bilirubin in modulating lipid status in vivo. These findings implicate the physiological importance of bilirubin in protecting from atherosclerosis by reducing thiol and subsequent lipoprotein oxidation, in addition to reducing circulating LDL concentrations.

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Peptidomic analysis reveals multiple protection of human breast milk on infants during different stages

Zhou

Zhang

et al. 2019

Journal Cellular Physiology

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It has been shown that human breast milk (HBM) is an important nutrient for the growth and development of newborns. Currently, peptide drugs provide promising regimes in neonatal disease treatment, especially peptides from HBM that exhibit multiple functions within cells. To explore the potential biological function peptides among the colostrum, transition and mature milk from mother of extremely low birth weight children (the samples were collected from Women's Hospital of Nanjing Medical University from December 2016 to February 2017). A total of 3,182 nonredundant peptides were identified and compared among colostrum, transitional and mature milk using liquid chromatography/mass spectrometry technology, and the numbers and fragments of peptides were various. The isoelectric point and molecular weight analysis of the differentially expressed peptides basically accord with the range of mass spectrometry identification (<3 kDa). Gene Ontology analysis and Pathway analysis, restriction sites analysis, as well as bioinformatics analysis showed that these differentially expressed peptides enriched a variety of biological processes. We identified several putative peptides that might have bioactive effects in diseases and development of newborns, which will inform further functional investigations. Our preliminary research provided a better understanding of the function of peptides during the newborn periods. Furthermore, it laid a foundation for discovering new peptide drugs in neonatal disease treatment.

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Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity

Cited by 28 publications

References 28 publications

Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity?

Retinopathy of prematurity risk factors: Does human milk prevent retinopathy of prematurity?

Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

Peptidomic analysis reveals multiple protection of human breast milk on infants during different stages

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