Possible roles of vinexinβ in growth and paclitaxel sensitivity in human prostate cancer PC-3 cells

Mizutani, Kosuke; Nagata, Koh‐ichi; Ito, Hidenori; Ehara, Hidetoshi; Nozawa, Yoshinori; Deguchi, Takashi

doi:10.4161/cbt.6.11.4862

Cited by 4 publications

(1 citation statement)

References 16 publications

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“…28 Also, as it has been described for ArgBP2, it seems that these adapter proteins may have distinct functions (sometime opposite) depending on the cellular context or population of their molecular partners. For example, Vinexin was shown to prone survival of prostate cancer cells, 29 but to be one of the genes under expressed in imatinib (a tyrosine kinase inhibitor designed to block BCR-Abl activity) resistant chronic myeloid leukemia. 30 Then, it is most probable that, like ArgBP2, CAP and Vinexin could be describe, in a near future, as directly involved in the tumoral progression of some cancers.…”

Section: Soho Family Of Protein In Oncogenic Processesmentioning

confidence: 99%

ArgBP2 and the SoHo family of adapter proteins in oncogenic diseases

Roignot

Soubeyran

2009

Cell Adhesion & Migration

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ArgBP2, a member of the SoHo family of adapter proteins, is a regulator of actin-dependent processes such as cell adhesion and migration. Recent data from our lab revealed that by regulating adhesion and migration of pancreatic cancer cells, ArgBP2 is endowed with an anti-tumoral function. We could show that part of the molecular mechanism involved the interaction of ArgBP2 with the Arp2/3 activator WAVE1, the tyrosine phosphatase PTP-PEST, and the tyrosine kinase c-Abl. As ArgBP2 shares common structural organization and overlapping functions with the two other members of this protein family, CAP and Vinexin, it raises the question whether these two other proteins could also be involved in cancer diseases. The control of cell migration being an important issue in tumor treatment, these recent findings suggest that ArgBP2 family-dependent signaling pathways represents potential targets for the development of therapeutic strategies, and highlight the importance of elucidating their molecular mechanisms of cytoskeletal regulation.

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Section: Soho Family Of Protein In Oncogenic Processesmentioning

confidence: 99%

ArgBP2 and the SoHo family of adapter proteins in oncogenic diseases

Roignot

Soubeyran

2009

Cell Adhesion & Migration

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RNA Interference for Cancer Therapy

Cheng

Qin

2009

Pharmaceutical Perspectives of Cancer Therapeutics

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Localization of multidomain adaptor proteins, p140Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka Long-Evans Tokushima Fatty rats

et al. 2013

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We have shown that two multidomain adaptor proteins, p140Cap and vinexin, interact with each other and are likely to be involved in neurotransmitter release. Because the basic molecular mechanism governing neurotransmitter and insulin secretion is conserved, these two proteins may also to play pivotal roles in insulin secretion. We therefore performed some characterization of p140Cap and vinexin in pancreas of a wild-type rat or a spontaneous type 2 diabetes mellitus (DM) model, the Otsuka Long-Evans Tokushima Fatty (OLETF) rat. These two proteins were detected in Wistar rat pancreas by Western blotting. Immunohistochemistry revealed that p140Cap and vinexin are enriched in β and α cells, respectively, in the rat pancreas. We then found that pancreatic islet structure was disorganized in the OLETF rat with hyperinsulinemia or with hyperglycemia, based on immunohistochemical analyses of vinexin. In β cells of these model rats, p140Cap was distributed in a cytoplasmic granular pattern as in the control rats, although its expression was reduced to various extents from cell to cell. These results may suggest possible involvement of p140Cap in insulin secretion, and reduction of p140Cap might be related to abnormal insulin secretion in DM.

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Possible roles of vinexinβ in growth and paclitaxel sensitivity in human prostate cancer PC-3 cells

Cited by 4 publications

References 16 publications

ArgBP2 and the SoHo family of adapter proteins in oncogenic diseases

ArgBP2 and the SoHo family of adapter proteins in oncogenic diseases

RNA Interference for Cancer Therapy

Localization of multidomain adaptor proteins, p140Cap and vinexin, in the pancreatic islet of a spontaneous diabetes mellitus model, Otsuka Long-Evans Tokushima Fatty rats

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