Possible sources and spreading routes of highly pathogenic avian influenza virus subtype H5N1 infections in poultry and wild birds in Central Europe in 2007 inferred through likelihood analyses

Haase, Martín; Starick, Elke; Fereidouni, Sasan; Strebelow, Günter; Grund, Christian; Seeland, Anett; Scheuner, Carmen; Cieslik, Dietmar; Smietanka, K.; Minta, Zenon; Zorman-Rojs, Olga; Mojžíš, Miroslav; Goletić, Teufik; Jestin, Véronique; Schulenburg, Bodo; Pybus, Oliver G.; Mettenleiter, Thomas C.; Beer, Martin; Harder, Timm C.

doi:10.1016/j.meegid.2010.07.005

Cited by 17 publications

(12 citation statements)

References 35 publications

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“…Here, we focused on swine influenza H3N2, however many different infectious diseases, especially RNA viruses, are suitable for molecular evolution analysis over a relatively short time period (although bacterial agents such as Borrelia burgdorferi have also been studied (Hoen et al, 2009). For example, recent efforts have been published that analyzed the geographic migration of H5N1 among avian and human populations over only a few years of data (Fusaro et al, 2010; Haase et al, 2010; Lam et al, 2008). In addition, phylogeography has been applied to other viruses beyond influenza such as rabies (Biek et al, 2007), West Nile Virus (Zehender et al, 2011), and Hantavirus (Lam et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Phylogeography of swine influenza H3N2 in the United States: Translational public health for zoonotic disease surveillance

Scotch

Mei

2013

Infection, Genetics and Evolution

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The field of phylogeography has received a lot of attention for its application to molecular evolution and geographic migration of species. More recent work has included infectious diseases especially zoonotic RNA viruses like influenza and rabies. Phylogeography of viruses has the potential to advance surveillance at agencies such as public health departments, agriculture departments, and wildlife agencies. However, little is known about how these agencies could use phylogeography for applied surveillance and the integration of animal and human sequence data. Here, we highlight its potential to support ‘translational public health’ that could bring sequence data to the forefront of surveillance. We focus on swine influenza H3N2 because of the recent link to a variant form in humans. We discuss the implications to applied surveillance and the need for an integrated biomedical informatics approach for adoption at agencies of animal and public health.

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Section: Discussionmentioning

confidence: 99%

Phylogeography of swine influenza H3N2 in the United States: Translational public health for zoonotic disease surveillance

Scotch

Mei

2013

Infection, Genetics and Evolution

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“…It occurred almost concomitantly with outbreaks in wild birds and/or poultry in central Europe. The French HPH5 viruses isolated in 2006 and 2007 belonged to the A/goose/Guangdong/1/1996 (Gs/Gd/1/96-like) lineage (clade 2.2 subgroup), as did the 2007 viruses from central Europe) [1-5]. Until 2014, H5N1 HPAI viruses belonging to the Gs/Gd/1/96-like lineage have been maintained in south-east Asia, the Middle East and Egypt, in different locations and their haemagglutinin (HA) genes evolved continuously into a wide range of clades and subclades.…”

Section: Introductionmentioning

confidence: 99%

Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential

et al. 2017

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Several new highly pathogenic (HP) H5 avian influenza virus (AIV) have been detected in poultry farms from south-western France since November 2015, among which an HP H5N1. The zoonotic potential and origin of these AIVs immediately became matters of concern. One virus of each subtype H5N1 (150169a), H5N2 (150233) and H5N9 (150236) was characterised. All proved highly pathogenic for poultry as demonstrated molecularly by the presence of a polybasic cleavage site in their HA protein – with a sequence (HQRRKR/GLF) previously unknown among avian H5 HPAI viruses – or experimentally by the in vivo demonstration of an intravenous pathogenicity index of 2.9 for the H5N1 HP isolate. Phylogenetic analyses based on the full genomes obtained by NGS confirmed that the eight viral segments of the three isolates were all part of avian Eurasian phylogenetic lineage but differed from the Gs/Gd/1/96-like lineage. The study of the genetic characteristics at specific amino acid positions relevant for modulating the adaptation to and the virulence for mammals showed that presently, these viruses possess most molecular features characteristic of AIV and lack some major characteristics required for efficient respiratory transmission to or between humans. The three isolates are therefore predicted to have no significant pandemic potential.

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“…A different third clade was responsible for cases during Period II, suggesting a third viral introduction in Europe. Although the origin of this clade has not been clearly determined, this introduction event could be linked to a drought in Eastern Europe (Gaidet et al, ; Haase et al, ; Hogerwerf et al, ; Takekawa et al, ). The sporadic cases observed in Period III raise questions about both the introduction by undetected carrier birds and the persistence of infections throughout the continent.…”

Section: Discussionmentioning

confidence: 99%

Fireworks‐like surveillance approach: The case of HPAI H5N1 in wild birds in Europe

Pereira

Artois

Bicout

2019

Transbound Emerg Dis

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Highly pathogenic avian influenza (HPAI) risk management requires efficient surveillance of the infection in wild birds for early warning purposes. In this study, our aim was to describe the spread of continent‐wide infection cases using a fireworks model and therefore improve current surveillance systems. The fireworks model is a metaphor illustrating the spread of HPAI as a point source epizootic. The approach is based on early detection of the outbreak seeds (sparks from the fireworks) and uses a predictive model of the probability of the occurrence of new cases following a seed introduction; this then determines the spatiotemporal perimeter for intense surveillance investigations. For a case study, we used surveillance data on HPAI H5N1 in wild birds across Europe between 2005 and 2010 to describe the outbreaks and determine the success of the case detection used to inform management of the disease. The fireworks description assumes simultaneous introductions of ‘seeds’ of cases, which then ‘explode’ in local foci but do not merge into a progressive disease wave. This model fits the data well. Using this predictive approach for HPAI cases in EU countries, we found that the investigation radius needed to achieve a detection level of 90% of new cases after an outbreak ranged from 10 km to more than 300 km, depending on the outbreak pattern. Based on these findings, the fireworks approach can be a valuable method for identifying the perimeters and risk areas to be targeted for enhanced surveillance. The rationale of the fireworks approach is quite generic and can easily be adapted to different situations and contexts.

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Possible sources and spreading routes of highly pathogenic avian influenza virus subtype H5N1 infections in poultry and wild birds in Central Europe in 2007 inferred through likelihood analyses

Cited by 17 publications

References 35 publications

Phylogeography of swine influenza H3N2 in the United States: Translational public health for zoonotic disease surveillance

Phylogeography of swine influenza H3N2 in the United States: Translational public health for zoonotic disease surveillance

Emerging highly pathogenic H5 avian influenza viruses in France during winter 2015/16: phylogenetic analyses and markers for zoonotic potential

Fireworks‐like surveillance approach: The case of HPAI H5N1 in wild birds in Europe

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