Possible Synergistic Effect of Curcumin on Captopril /Losartan Combined Therapy in Diabetic Nephropathy

Hassanin, Amany H.; Elmasry, Khaled; Saleh, Dalia; Bondok, Adel A.

doi:10.21608/zumj.2022.111158.2433

Cited by 1 publication

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“…17,18 Combining ARBs with natural products like curcumin and resveratrol has been proven to be more successful in lowering metabolic disturbances, inflammation, insulin resistance (IR), hypertension, and a variety of other diabetic problems. 19,20 Flavonoids found in medicinal plants, vegetables, and fruits have the potential to be a novel medication source. In this regard, quercetin (C 15 H 10 O 7 ) is a well-known flavonoid with antihypertensive 21 and renoprotective properties.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats

Ali¹,

Ahmed²,

Aziz³

2022

JIR

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The present study was designed to evaluate the possible synergistic effects of telmisartan and quercetin in 5 fluorouracil (5-FU) induced nephrotoxicity in rats. Methodology: Forty male rats were randomly divided into five groups: The negative control group, the positive control group that received 5-FU, the telmisartan group, receiving 10 mg/kg, the quercetin group, receiving 80 mg/kg, and the combination of telmisartan and quercetin group. All the treatments were given orally for 14 days. A single intraperitoneal injection of 5-FU (150 mg/kg) on day 13 of the experiment was given except for the negative control group. On the 15th day after scarification, approximately 5 mL of blood was collected and used for measurement of CBC, urea, creatinine, and uric acid. The kidneys were used for histopathological examination and for the measurement of kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), Cystatin C (Cys-C), and total antioxidant capacity (TAOC). Results: The combination therapy significantly attenuated the levels of tissue KIM-1, NGAL, Cys-C, and serum uric acid as well as blood inflammatory markers, Neutrophil/Lymphocyte (NLR), Monocyte/Lymphocyte (MLR), and Platelets/Lymphocyte ratios (PLR), and restored the TAOC. The histopathological findings greatly support the biochemical tests. Conclusion:The results strongly suggest the renoprotective effects of telmisartan and quercetin in combination against the nephrotoxic effect of 5-FU through decreasing the levels of KIM-1, NGAL, and cys-C, and the novel inflammatory markers of kidney injury like NLP, MLR, and PLR, as well as decreasing uric acid and restoring the TAOC. The proposed mechanism could be the additive inhibitory effect on RAS provided by both telmisartan and quercetin.

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Section: Introductionmentioning

confidence: 99%

“…Combining ARBs with natural products like curcumin and resveratrol has been proven to be more successful in lowering metabolic disturbances, inflammation, insulin resistance (IR), hypertension, and a variety of other diabetic problems. 19 , 20 …”

Section: Introductionmentioning

confidence: 99%