Possible therapeutic potential of berberine in diabetic osteopathy

Rahigude, Anand; Kaulaskar, Shyam; Bhutada, Pravinkumar

doi:10.1016/j.mehy.2012.06.016

Cited by 12 publications

(5 citation statements)

References 46 publications

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“…Diabetic osteopathy is a diabetes complication that results in reduced bone mineral density and bone formation due to increased osteoclastogenesis and reduced osteoblastogenesis [67]. BBR reduces osteoclast differentiation and activity [68] and increases osteoblast differentiation and activity [69], suggesting a potential role in the treatment of this pathological condition, likely through the activation of AMPK signaling pathway [70].…”

Section: Mesangial Cells Dysfunction Of Mesangial Cells Is a Hallmarmentioning

confidence: 99%

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

2015

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Section: Mesangial Cells Dysfunction Of Mesangial Cells Is a Hallmarmentioning

confidence: 99%

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

2015

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“…Urolithiasis: B. vulgaris : Jyothilakshmi et al, 2013[ 65 ]; Bashir and Gilani, 2011[ 10 ]. Osteolytic and Hyper choletrolemic: B. aristata : Zhou et al, 2012[ 149 ]; Rahigude et al, 2012[ 102 ]; Dong et al, 2011[ 32 ]; Huang et al, 2012[ 51 ]).…”

Section: Pharmacological Activities Of Berberis Speciesmentioning

confidence: 99%

A review on biological and chemical diversity in Berberis (Berberidaceae)

Srivastava

Misra

et al. 2015

EXCLI Journal; 14:Doc247; ISSN 1611-2156

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“…Previous studies have discovered a close association between peroxisome proliferatoractivated receptor (PPAR) and the pathogenic mechanism of osteoarthritis (Lee et al, 2012;Rahigude et al, 2012;Chen et al, 2015). Thiazolidinediones such as pioglitazone, rosiglitazone, and troglitazone are the major synthetic ligands of PPARα that have found clinical application (Mahali et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Role of PPARα in down-regulating AGE-induced TGF-β and MMP-9 expressions in chondrocytes

Wang¹,

Wang²,

Sun³

2016

Genet. Mol. Res.

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ABSTRACT. Peroxisome proliferator-activated receptor is closely associated with the pathogenesis of osteoarthritis. The level of exogenous advanced glycation end-products (AGEs) in articular cartilage is highly associated with the severity of osteoarthritic lesions. However, their interactions and role in promoting osteoarthritisprogression remain unclear. Here, we investigated the effect of AGEs on transforming growth factor (TGF)-β and matrix metalloproteinase (MMP)-9 expression, and discussed the correlation between AGEs and osteoarthritis, possible signaling pathways and mechanism in rabbit chondrocytes. TGF-β and MMP-9 mRNA and protein expression, catalase (CAT) and superoxide dismutase (SOD) activity, and malondialdehyde (MDA) and reactive oxygen species (ROS) levels were analyzed in chondrocytes treated with different concentrations of AGEs using RT-PCR and/or western blot; we detected NF-κB nuclear translocation by immunofluorescence. AGE treatment significantly increased TGF-β and MMP-9 mRNA and protein expression compared to controls (P < 0.01) in a dose-dependent manner (highest at 100 µg/mL). AGE-induced TGF-β and MMP-9 expressions in chondrocytes were significantly inhibited by anti-RAGE and PDTC (0.1 mM) treatment (P < 0.01). Furthermore, AGE-treatment significantly decreased CAT and SOD activity and increased MDA levels in a concentration-dependent manner compared to controls (P < 0.05), significantly promoting NF-κB nuclear translocation. AGE significantly inhibited the increased expression of TGF-β and MMP-9, and induced chondrocyte damage. Its mechanism is associated with RAGE activation, increased ROS expression, and activation of the NF-κB signaling pathways.

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Possible therapeutic potential of berberine in diabetic osteopathy

Cited by 12 publications

References 46 publications

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

Berberine, a plant alkaloid with lipid- and glucose-lowering properties: From in vitro evidence to clinical studies

A review on biological and chemical diversity in Berberis (Berberidaceae)

Role of PPARα in down-regulating AGE-induced TGF-β and MMP-9 expressions in chondrocytes

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