Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn

Dong, Liang; Tian, Jian; He, Songming; Zhu, Chenfeng; Wang, Jian; Liu, Chen; Yang, Jing

doi:10.1001/jama.2020.4621

Cited by 1,063 publications

(1,499 citation statements)

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“…This rapid review included five case reports with data on breast milk samples from thirteen mothers with COVID-19 (2,(18)(19)(20)(21). The test results for SARS-CoV-2 nucleic acid were all negative.…”

Section: Discussionmentioning

confidence: 99%

“…of 3.49 (95% CI: 3.42 to 3.58) based on 27,100 confirmed cases from January 17 to February 8, 2020 in Hubei province without intervention (33), which is similar to SARS (R0 2.2-3.6) (34), but clearly higher than Influenza A H1N1 (R0 1.4-1.6) (35). But according to the five case reports (2,(18)(19)(20)(21) found by our review the nucleic acid test results for SARS-CoV-2 of breast milk samples from thirteen mothers with COVID-19 were all negative. No studies have reported the existence of virus nucleic acid in breast milk from mothers infected with SARS, MERS or influenza.…”

Section: Covid-19 Is Relatively Contagious With An Estimated Basic Rementioning

confidence: 97%

“…After screening the titles and abstracts, we retrieved 44 articles for full-text screening. Six articles were finally included for data extraction ( Table 1): five case reports (2,(18)(19)(20)(21) from China published in 2020 on mothers with COVID-19 and their infants, and one case series (22) from the US published in 2013 reporting the effect of precautions for breastfeeding mothers infected with influenza. Because of effect sizes could not be pooled, we reported the study findings narratively.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Because of no comparable data could be pooled, we reported the study findings narratively. The five case reports (2,(18)(19)(20)(21) included sixteen breastfeeding mothers with COVID-19. The first case report showed that neonates of nine mothers with COVID-19…”

Section: Breastfeedingmentioning

confidence: 99%

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Breastfeeding of Infants Born to Mothers with COVID-19: A Rapid Review

Yang

Che

Zhang

et al. 2020

Preprint

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Background: Existing recommendations on whether mothers with COVID-19 should continue breastfeeding are still conflicting. We aimed to conduct a rapid review of mother-to-child transmission of COVID-19 during breastfeeding. Methods:We systematically searched Medline, Embase, Web of Science, Cochrane library, China Biology Medicine disc, China National Knowledge Infrastructure, Wanfang, and preprint articles up to March 2020. We included studies relevant to transmission through milk and respiratory droplets during breastfeeding of mothers with COVID-19, SARS, MERS and influenza. Two reviewers independently screened studies for eligibility, extracted data, assessed risk of bias and used GRADE to assess certainty of evidence.Results: A total of 4481 records were identified in our literature search. Six studies (five case reports and one case series) involving 58 mothers (16 mothers with COVID-19, 42 mothers with influenza) and their infants proved eligible. Five case reports showed that the viral nucleic acid tests for all thirteen collected samples of breast milk from mothers with COVID-19 were negative.A case series of 42 influenza infected postpartum mothers taking precautions (hand hygiene and wearing masks) before breastfeeding showed that no neonates were infected with influenza during one-month of follow-up. Conclusions:The current evidence indicates that SARS-CoV-2 viral nucleic acid has not been detected in breast milk. The benefits of breastfeeding may outweigh the risk of SARS-CoV-2 infection in infants. Mothers with COVID-19 should take appropriate precautions to reduce the All rights reserved. No reuse allowed without permission.

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Section: Discussionmentioning

confidence: 99%

Section: Covid-19 Is Relatively Contagious With An Estimated Basic Rementioning

confidence: 97%

Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Breastfeedingmentioning

confidence: 99%

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Breastfeeding of Infants Born to Mothers with COVID-19: A Rapid Review

Yang

Che

Zhang

et al. 2020

Preprint

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“…Recently, a report from China described three infants with elevated serum levels of IgG and IgM antibodies for SARS-CoV-2 after birth. 12,13 The postnatal courses were benign and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal swabs, serum, vaginal secretions, and maternal breast milk were negative. Thus, in the light of negative RT-PCR results and given that IgM false positives results are not uncommon, and that the decline of IGM levels were very unusual in comparison with other congenital https://doi.org/10.1016/j.jped.2020.04.002 0021-7557/© 2020 Sociedade Brasileira infections, the possibility of maternal-infant transmission is difficult to ascertain.…”

mentioning

confidence: 99%

Neonatal COVID-19: little evidence and the need for more information

Procianoy¹,

Silveira²,

Manzoni³

et al. 2020

Jornal de Pediatria

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Based on available reports (up to the writing of this editorial) and on scientific data reported by China, Italy, and the United States, newborn infants appear to be significantly less affected by COVID-19 than adults. 1---3 However, the lack of high-quality evidence for this situation and the steadfast pace of new and conflicting information has been an overall challenge to all medical specialties, including neonatal intensive care. In reality, the current knowledge on neonatal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. Therefore, several questions remain unanswered, while at the same time the neonatal community needs to take action. Not surprisingly, this has caused significant stress amongst neonatal health care providers.All over the world, a number of important groups have been diligently working on the development of protocols ଝ Please cite this article as: Procianoy RS, Silveira RC, Manzoni P, Sant'Anna G. Neonatal COVID-19: little evidence and the need for more information. J Pediatr (Rio J). 2020. https://doi.

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