Post-acute COVID-19 syndrome: a new tsunami requiring a universal case definition

Lledó, Gema; Sellarés, Jacobo; Brotons, Carlos; Antón, Juana Díez; Miro, José Maria Ribeiro; Sanjosé, Sílvia de; Miró, Josep M.; Bassat, Quique; Campins, Magda; Guerri, Robert; Brotons, Carlos; Díez, Juana; Blanco, Julià; Sans, Mireia; Sarukhan, Adélaïda; Plasència, Antoni; Antó, Josep M.

doi:10.1016/j.cmi.2021.11.015

Cited by 30 publications

(29 citation statements)

References 23 publications

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“…The UK's Office for National Statistics assessed that one in five patients report symptoms beyond 5 weeks, while 10% have symptoms persevering over 12 weeks [5]. Improving the handling of these patients needs the contextualization and classification of the long-term symptoms [6]. Actually, there are varied nomenclatures and time ranges (3,4 or 12 weeks) used to explain the condition, inadequate knowledge on its etiology and a lack of evidence for the possible treatments [6].…”

Section: Introductionmentioning

confidence: 99%

“…Improving the handling of these patients needs the contextualization and classification of the long-term symptoms [6]. Actually, there are varied nomenclatures and time ranges (3,4 or 12 weeks) used to explain the condition, inadequate knowledge on its etiology and a lack of evidence for the possible treatments [6]. Indeed, various authors have used different names such as "post-COVID-19 syndrome", "long COVID-19", "long-term COVID-19 effects", "long haulers" and "persistent COVID-19…”

Section: Introductionmentioning

confidence: 99%

“…The original cause of the persistence of symptoms has yet to be recognized, but several hypotheses have been produced [6]: aberrant immune responses, virus-specific pathophysiological alterations, inflammatory damage in response to the acute infection [9] and mechanisms of viral persistence in certain tissues [10,11], SARS-CoV-2 interactions with host microbiome/virome communities, clotting/coagulation issues and dysfunctional brainstem/vagus nerve signaling [12]. Moreover, the roles of exosomes and mast cells [13][14][15] recently came under consideration.…”

Section: Introductionmentioning

confidence: 99%

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Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems

Visco

Vitale

Rispoli

et al. 2022

JCM

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Though the acute effects of SARS-CoV-2 infection have been extensively reported, the long-term effects are less well described. Specifically, while clinicians endure to battle COVID-19, we also need to develop broad strategies to manage post-COVID-19 symptoms and encourage those affected to seek suitable care. This review addresses the possible involvement of the lung, heart and brain in post-viral syndromes and describes suggested management of post-COVID-19 syndrome. Post-COVID-19 respiratory manifestations comprise coughing and shortness of breath. Furthermore, arrhythmias, palpitations, hypotension, increased heart rate, venous thromboembolic diseases, myocarditis and acute heart failure are usual cardiovascular events. Among neurological manifestations, headache, peripheral neuropathy symptoms, memory issues, lack of concentration and sleep disorders are most commonly observed with varying frequencies. Finally, mental health issues affecting mental abilities and mood fluctuations, namely anxiety and depression, are frequently seen. Finally, long COVID is a complex syndrome with protracted heterogeneous symptoms, and patients who experience post-COVID-19 sequelae require personalized treatment as well as ongoing support.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems

Visco

Vitale

Rispoli

et al. 2022

JCM

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“…The first cases of COVID-19 occurred in December 2019 and Spain was one of the most affected countries during the first wave of COVID-19 (March to June) [ 5 – 11 ]. Then it was devastated by a second wave of COVID-19 infections [ 12 , 13 ] and all subsequent waves that have devastated the entire planet and caused the greatest medical problem experienced by humanity in recent decades. In the severe pandemic context biobanks have become even more essential than before [ 14 – 17 ].…”

Section: Introductionmentioning

confidence: 99%

HIV HGM biobank as a research platform for paediatric infectious diseases and COVID-19 pandemic

et al. 2022

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Aim The initial cases of COVID-19 appeared in December 2019 and Spain was one of the most affected countries during the first wave (March to June). Since then, HIV HGM BioBank has been restructured as an established Paediatrics and Adults HIV_COVID-19 BioBank that aims at the long-term storage of samples obtained from not only HIV-1, but also from COVID-19 patients and HIV-1_COVID-19 coinfected patients. Methods HIV HGM BioBank holds high quality biological samples from newborns, children, adolescents and adults with their associated clinical data. Research groups trying to establish large networks focused on research on specific clinical problems in epidemiology, biology, routes of transmission and therapies, are potential users of the clinical samples and of associated data of HIV-1_COVID-19 HGM BioBank. Results The HIV HGM BioBank is an academic and ethical enterprise complying with all the legal regulatory rules to provide service to the society. HIV_COVID-19 HGM BioBank has been repurposed to offer an important resource for global research of COVID-19 in newborns, children, adolescents, adults and elders to study the biological effect of the pandemic. Conclusion Herein, we present a description of how HIV HGM BioBank has rapidly become an indispensable structure in modern biomedical research, including COVID-19 research.

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“…The natural history of NeuroCOVID shows that approximately 21 days after the onset of the acute phase of COVID-19 symptoms, the post-COVID-19 phase begins [6] , which, if concentrated in sequelae or new neurological manifestations, is known as post-COVID-19 neurological syndrome [7] , [8] , [9] . It has been described that this is a risk period where the neuroinflammation caused by SARS-Cov-2 remains active and precipitates the development of complications due to neuroimmunological alterations, which may facilitate the appearance of co-infections [7] , [8] , [9] .…”

mentioning

confidence: 99%

Letter: Spectrum of hospitalized NeuroCOVID diagnoses from a tertiary care neurology centre in Eastern India

Leal-Buitrago

Mondragon-Ángulo

Cely-Aldana

et al. 2022

Journal of Clinical Neuroscience

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Post-acute COVID-19 syndrome: a new tsunami requiring a universal case definition

Cited by 30 publications

References 23 publications

Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems

Post-COVID-19 Syndrome: Involvement and Interactions between Respiratory, Cardiovascular and Nervous Systems

HIV HGM biobank as a research platform for paediatric infectious diseases and COVID-19 pandemic

Letter: Spectrum of hospitalized NeuroCOVID diagnoses from a tertiary care neurology centre in Eastern India

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