Post-acute sequelae of COVID-19 in a non-hospitalized cohort: Results from the Arizona CoVHORT

Bell, Melanie L.; Catalfamo, Collin J; Farland, Leslie V.; Ernst, Kacey C.; Jacobs, Elizabeth T.; Klimentidis, Yann C.; Jehn, Megan; Pogreba-Brown, Kristen

doi:10.1371/journal.pone.0254347

Cited by 133 publications

(114 citation statements)

References 13 publications

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“…Complications of COVID-19 have been observed in many prospective cohort studies indicating the importance of a follow-up of COVID-19 patients [19,[46][47][48]. In general, the frequency and severity of these complications or "sequelae" are associated with acute COVID-19 illness [4,31,49], and our results are consistent with these studies, these being hair loss, fatigue, and loss of smell or taste such as more frequent reported persistent symptoms in a multi-system affectation [21,46,[50][51][52][53].…”

Section: Discussionsupporting

confidence: 91%

Complications Post-COVID-19 and Risk Factors among Patients after Six Months of a SARS-CoV-2 Infection: A Population-Based Prospective Cohort Study

Domènech-Montoliu¹,

Puig-Barberà

Pac-Sa³

et al. 2022

Epidemiologia

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In October 2020, we conducted a population-based prospective cohort study to determine post-COVID-19 complications, recovery, return to usual health, and associated risk factors in 536 cases of COVID-19 outbreak in Borriana (Spain) by administering an epidemiological questionnaire via phone interviews. A total of 484 patients participated (90.3%), age mean 37.2 ± 17.1 years, and 301 females (62.2%). Mild illness was the most common COVID-19 manifestation. After six months, 160 patients (33.1%) suffered at least one complication post-COVID-19, and 47 (29.4%) of them sought medical assistance. The most frequent persistent symptoms were hair loss, fatigue, loss of smell or taste, and headache. Risk factors associated with a complication were female sex (adjusted relative risk, [aRR] = 1.93 95% confidence interval [CI] 1.41–2.65), age 35 years and above (aRR = 1.50 95% CI 1.14–1.99), B blood group (aRR = 1.51 95% CI 1.04–2.16), current smoker (RR = 1.61 95% CI 1.02–2.54), and at least a COVID-19 exposure (aRR = 2.13 95% CI 1.11–4.09). Male sex, age younger than 35 years, and low COVID-19 exposures were associated with better recovery and return to usual health. A third of patients presented persistent symptoms compatible with the long-COVID-19 syndrome. In conclusion, an active medical follow-up of post-COVID-19 patients must be implemented.

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Section: Discussionsupporting

confidence: 91%

Complications Post-COVID-19 and Risk Factors among Patients after Six Months of a SARS-CoV-2 Infection: A Population-Based Prospective Cohort Study

Domènech-Montoliu¹,

Puig-Barberà

Pac-Sa³

et al. 2022

Epidemiologia

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“… 55 Post-COVID conditions can affect people with mild disease through to those hospitalised with severe and critical disease. 56 The WHO's definition of post-COVID conditions is symptoms usually occurring 3 months from the onset of COVID-19, that last for ≥ 2 months and cannot be explained by an alternative diagnosis. 57 Symptoms may be persistent from the time of the initial COVID-19 infection or be new in onset and can be fluctuating or remitting over time.…”

Section: Methodsmentioning

confidence: 99%

Physiotherapy management for COVID-19 in the acute hospital setting and beyond: an update to clinical practice recommendations

Thomas

Baldwin

Beach

et al. 2022

Journal of Physiotherapy

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This document provides an update to the recommendations for physiotherapy management for adults with coronavirus disease 2019 (COVID-19) in the acute hospital setting. It includes: physiotherapy workforce planning and preparation; a screening tool for determining requirement for physiotherapy; and recommendations for the use of physiotherapy treatments and personal protective equipment. New advice and recommendations are provided on: workload management; staff health, including vaccination; providing clinical education; personal protective equipment; interventions, including awake proning, mobilisation and rehabilitation in patients with hypoxaemia. Additionally, recommendations for recovery after COVID-19 have been added, including roles that physiotherapy can offer in the management of post-COVID syndrome. The updated guidelines are intended for use by physiotherapists and other relevant stakeholders caring for adult patients with confirmed or suspected COVID-19 in the acute care setting and beyond.

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“…COVID-19 is now recognized as a multi-organ disease with considerable mortality in risk groups [3][4][5]. With a growing population of recovering patients, it became clear that in 32-87% of patients (including those with mild acute disease) health impairments persist beyond the acute phase of infection [6][7][8][9][10]. The most common definition of such post-acute sequelae of COVID-19 (PASC) is persistence of symptoms beyond four weeks [6,7].…”

Section: Introductionmentioning

confidence: 99%

From online data collection to identification of disease mechanisms: The IL-1ß, IL-6 and TNF-α cytokine triad is associated with post-acute sequelae of COVID-19 in a digital research cohort

Willscher

Paschold

Gottschick

et al. 2021

Preprint

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Post-acute sequelae of COVID-19 (PASC) emerge as a global problem with unknown molecular drivers. In a digital epidemiology approach, we rapidly recruited 8,077 individuals out of 129,733 households in Halle (Saale) to the cohort study for digital health research in Germany (DigiHero). These responded to a basic questionnaire followed by a PASC-focused survey and blood sampling in case of prior positive SARS-CoV-2 testing in their household. The presented analysis is based on the first 318 DigiHero participants, the majority thereof after mild infections. PASC were reported in 67.8% of cases, consisted predominantly in fatigue, dyspnea and concentration deficit, persisted in 60% over the follow-up period of on average eight months and their resolution was unaffected by post-infection vaccination. PASC was not associated with post-COVID-19 autoantibodies, but with elevated levels of IL-1ß, IL-6 and TNF-α. Blood profiling and single-cell data from validation cohorts with early infection suggested the induction of these cytokines in COVID-19 lung pro-inflammatory macrophages creating a self-sustaining feedback loop. Our data indicate a long-lasting cytokine triad -potentially underlying PASC symptoms - to be driven by macrophage primed during infection. We demonstrate how the combination of digital epidemiology with selective biobanking can rapidly generate hints towards disease mechanisms.

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Post-acute sequelae of COVID-19 in a non-hospitalized cohort: Results from the Arizona CoVHORT

Cited by 133 publications

References 13 publications

Complications Post-COVID-19 and Risk Factors among Patients after Six Months of a SARS-CoV-2 Infection: A Population-Based Prospective Cohort Study

Complications Post-COVID-19 and Risk Factors among Patients after Six Months of a SARS-CoV-2 Infection: A Population-Based Prospective Cohort Study

Physiotherapy management for COVID-19 in the acute hospital setting and beyond: an update to clinical practice recommendations

From online data collection to identification of disease mechanisms: The IL-1ß, IL-6 and TNF-α cytokine triad is associated with post-acute sequelae of COVID-19 in a digital research cohort

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