Post-coital ultrastructural changes in neurons of the suprachiasmatic nucleus of the rabbit

Clattenburg, R. E.; Singh, Roderick P.; Montemurro, Donald G.

doi:10.1007/bf00306653

Cited by 36 publications

(19 citation statements)

References 27 publications

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“…The mechanism involved is unknown, although a direct projection from the SCN to the internal lamina of the median eminence is present in the rat [40]. In addition, LH-RFi positive perikarya have been reported in the suprachiasmatic area in rats [36], and neuro secretory activity has been observed in some SCN neurons after ovariectomy [6] or mating [7] in the rabbit, a copulation-induced ovulator.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Ablation of the Suprachiasmatic Nucleus. Effects on the Development of the Pituitary-Gonadal Axis in the Female Rat

Mosko¹,

Moore²

1979

Neuroendocrinology

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Ablation of the suprachiasmatic nucleus (SCN) at 2 days of age, prior to the formation of the retinohypothalamic projection, produces a permanent state of constant vaginal estrus in the postpubertal female rat. Although such lesions do not alter the onset of puberty in sighted rats, they do compensate for the delay in vaginal opening induced by neonatal blinding. The ovaries of sighted and blinded SCN-lesion rats are small and polyfoUicular and the pituitaries of blinded SCN-lesion rats are abnormally large. Sampling of plasma in the morning and afternoon for up to 12 consecutive days in sighted SCN-lesion rats reveals continuously low luteinizing hormone levels. This constellation of endocrine alterations does not correlate with damage to any structures outside the SCN. Since the organization of the rodent estrous cycle is circadian, these results emphasize further the importance of the SCN in circadian rhythm generation. The necessity of an intact SCN for the development of normal, cyclic reproductive function implies that sparing or recovery of function does not occur.

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Section: Discussionmentioning

confidence: 99%

Neonatal Ablation of the Suprachiasmatic Nucleus. Effects on the Development of the Pituitary-Gonadal Axis in the Female Rat

Mosko¹,

Moore²

1979

Neuroendocrinology

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“…Suburo and P elleg rin o de I r a ld i [1969] found that small granulated vesicles respond to various endo crine states such as castration and post-coitus by cellular changes indicative of enhanced protein synthetic activity. These could be the parvicellular cells responsible for LH-RH or other releasing factors and act as sites for steroid feedback [Clattenberg et al, 1972[Clattenberg et al, , 1975. V andesande et al [1974] reported changes in neurophysin or vasopressin in the SCN following adrenalectomy while Z immerman [1976] detected no changes in these constituents.…”

mentioning

confidence: 99%

Effects of Continuous Light and Darkness, and of Pinealectomy, Adrenalectomy and Gonadectomy on Uptake of <sup>3</sup>H-Serotonin by the Suprachiasmatic Nuclear Region of Male Rats

Meyer¹,

Quay²

1976

Neuroendocrinology

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Rats exposed to continuous light show no significant differences in serotonin (5-HT) uptake by the suprachiasmatic nuclear region (SNR) at 10.00 and 22.00 L, while in continuous darkness, the uptake at 10.00 D is significantly higher than uptake at 22.00 D. In consideration of the role of the suprachiasmatic nucleus in light-mediated control of neuroendocrine activity, this suggests endogenous generation or control of this uptake rhythm. An effect of sham-pinealectomy in decreasing 5-HT uptake was found, but cannot be fully interpreted at this time. The lack of effect of castration or adrenalectomy suggests that these endocrines have little if any direct effect on 5-HT mechanisms in the SNR.

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“…On the contrary, there are many observations suggesting an involvement of the SCN in reproductive processes. As long as 20 years ago, post-coital ultrastructural changes indicating neuronal activation were observed in the female rabbit SCN (81). It is also important to note that the activity of SCN neurons increases suddenly around puberty (82), which is indicative of the addition of a reproductive function to the already matured circadian functions of rat SCN.…”

Section: The Suprachiasmatic Nucleus Sexual Orientation and Reproducmentioning

confidence: 94%

Sexual differentiation of the human brain

et al. 1997

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• Sex differences in the structures of human hypothalaiiius and adjacent brain structures have been observed that seem to be related to gender, to gender problems such as transsexuality, and to sexual orientation, that is, heterosexual! ty and homosexuality. A Ithough these observations have yet to be confirmed, and their exact functional implications are far from clear, they open up a whole new field of structuralfunctional relationships in human brain research.

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Post-coital ultrastructural changes in neurons of the suprachiasmatic nucleus of the rabbit

Cited by 36 publications

References 27 publications

Neonatal Ablation of the Suprachiasmatic Nucleus. Effects on the Development of the Pituitary-Gonadal Axis in the Female Rat

Neonatal Ablation of the Suprachiasmatic Nucleus. Effects on the Development of the Pituitary-Gonadal Axis in the Female Rat

Effects of Continuous Light and Darkness, and of Pinealectomy, Adrenalectomy and Gonadectomy on Uptake of <sup>3</sup>H-Serotonin by the Suprachiasmatic Nuclear Region of Male Rats

Sexual differentiation of the human brain

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