Post‐Condensation Modifications of the Passerini and Ugi Reactions

Multicomponent Reactions-Based Modified/Functionalized Materials in the Biomedical Platforms

“…The research field of IMCRs over the past 2 decades has experienced fantastic development with discovery of innovative variations of the classical Ugi and Passerini MCRs . IMCRs via readily accessible starting materials are easily performed and achieved a diverse type of functional groups; furthermore, by arrangement with other transformations they have also delivered an ideal tool for obtaining large and miscellaneous chemical spaces. , In 1881, Hantzsch et al reported an earlier example of non-isocyanide-based MCRs . Another well-known example is the Biginelli reaction that was discovered in 1891 .…”

Multicomponent reactions in nucleoside chemistry

“…Many excellent comprehensive reviews on MCRs have been published. The reviews have covered the significant topics in this field, such as: (a) the applications of MCRs in the drug discovery process [ 15 – 20 ], or in the total synthesis [ 21 – 22 ]; (b) strategies developed for the construction of new structural frameworks [ 23 ]; (c) the use of specific building blocks [ 24 – 28 ], reagents [ 29 – 32 ], catalysts [ 33 ], reaction conditions [ 34 – 35 ], or preparative techniques [ 36 ] in MCRs; (d) methods for the design of new MCRs [ 37 – 38 ]; or (e) higher-order MCRs [ 39 ]. However to date, the application of MCRs in the chemistry of nucleoside analogs has not been methodically discussed.…”

Rapid Synthesis of Cyclopeptide Alkaloid‐Like para‐Cyclophanes by Combined Use of Ugi‐4CR and Intramolecular SNAr Reaction

“…However, an alternative and highly efficient strategy involving a sequence of multicomponent reactionpost functionalization has attracted much attention over the past decade [9] and indeed this strategy has been developed into a powerful method for the syntheses of a variety of heterocycles and macrocycles [10]. In connection with our ongoing project aiming at the development of step-efficient syntheses of natural product-like compounds [11], a sequence of an Ugi four-component reaction (Ugi-4CR) followed by an intramolecular S N Ar reaction has been developed for the synthesis of macrocycles with an endo aryl -aryl ether bond [12,13].…”