Post-COVID-19 Cholestasis: A Case Series and Review of Literature

Post-COVID-19 Cholangiopathy: A Systematic Review

“…Sixty-eight percent of the patients previously reported had continued elevation in transaminases and alkaline phosphatase post COVID-19 recovery. Studies published after our review suggest a possible role of plasmaphereses as a bridge to transplant [ 21 , 24 , 26 ]. The proposed beneficial mechanism of action for plasmaphereses is the removal of antibodies from that can be contributing to liver injury.…”

“…The proposed beneficial mechanism of action for plasmaphereses is the removal of antibodies from that can be contributing to liver injury. In the study plasma exchange was done in five patients, and two were successfully bridged to living donor liver transplantation in the unvaccinated group of the study [ 24 ]. A number of studies have emerged discussing liver disease and PCC describing up to 250 cases however these studies did not meet our search criteria therefore are not included, which shows the relevance of the diseases by replication of the publications [ 21 , 22 , 23 , 24 , 25 , 26 ].…”

“…For instance, studies included in our review were published largely before immunization against COVID-19 was available. The results of recent case series by Anand et al describes a potential lower risk of liver failure in Covid-19 immunized individuals [ 24 ]. Plasma exchange was done in five patients, and two were successfully bridged to living donor liver transplantation in unvaccinated group.…”

“…Plasma exchange was done in five patients, and two were successfully bridged to living donor liver transplantation in unvaccinated group. [ 24 ].…”

Poor immune response to coronavirus disease vaccines in decompensated cirrhosis patients and liver transplant recipients

“… [2] , [16] , [17] , [18] Although vaccination does not prevent infection, all vaccines reduce the need for hospitalization, modify the course of the disease, and improve the short-term and long-term outcomes of viral pneumonia. [6] , [8] , [19] , [20] Therefore, patients with cirrhosis should be vaccinated as a priority group to prevent and modify the course of vaccine-modifiable diseases, including COVID-19. [16] , [21] …”