Post-COVID-19 reactive arthritis

Slouma, M.; Abbés, M.; Kharrat, L.; Gharsallah, I.

doi:10.1007/s10067-022-06241-9

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…While all of these effects were comparatively strong, only the influence of COVID-19 on orthopedic issues retained its significance even after accounting for multiple testing. Accordingly, examining the source variables results corrected for type I errors, our findings regarding 'orthopedic disorders' in males and 'metabolic disorders' and 'physical health disparity' in females were in agreement with those studies that observed deteriorated physical health in these areas in post-COVID19 patients (for reviews on orthopedic disorders see (Slouma, Abbes, Kharrat, & Gharsallah, 2022) and (Slouma et al, 2023) and for a review on metabolic disorders see (Steenblock et al, 2021). With regard to cognitive functions, our study's findings on females' reading time scores are consistent with earlier studies that have found an association between COVID-19 infection and impairment in information processing speed (Almeria, Cejudo, Sanz-Santos, Deus, & Krupinski, 2023;Ferrucci et al, 2021;Flegr & Latifi, 2023).…”

Section: Discussionsupporting

confidence: 90%

Is Recovery Just the Beginning? Persistent Symptoms and Health and Performance Deterioration in Post-COVID-19, non-hospitalised University Students - A Cross-Sectional Study

Latifi,

Flegr

2023

Preprint

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Many individuals experience persistent symptoms such as deteriorated physical and mental health, increased fatigue, and reduced cognitive performance months after recovering from COVID-19. Current data are limited on the long-term trajectory of these symptoms and their prevalence in milder cases. Our study aimed to assess the persistent effects of COVID-19 on physical and mental health, fatigue, and cognitive performance in a cohort of 214 students, averaging 21.8 years of age. Of these, 148 had contracted COVID-19 but were not hospitalized, with the time since infection ranging from 1 to 39 months. We utilized a comprehensive panel of cognitive tests to measure intelligence, memory, and psychomotor skills, and a detailed anamnestic questionnaire to evaluate physical and mental health. While contracting COVID-19 did not significantly impact overall health and performance, it was associated with increased reports of fatigue. However, the reported severity of the disease had a pronounced negative influence on physical health, mental well-being, fatigue, and reaction time. Trends of improvement in physical and mental health, as well as error rate, were observed within the first two years post-infection. However, fatigue and reaction time showed a trend of deterioration. Beyond the two-year mark, physical health and error rate continued to improve, while mental health began to deteriorate. Fatigue and reaction time continued to decline. Overall, our findings suggest that some effects of contracting COVID-19 can persist or even deteriorate over time, even in younger individuals who had mild cases that did not require hospitalization.

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Section: Discussionsupporting

confidence: 90%

Is Recovery Just the Beginning? Persistent Symptoms and Health and Performance Deterioration in Post-COVID-19, non-hospitalised University Students - A Cross-Sectional Study

Latifi,

Flegr

2023

Preprint

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“…Since the breakout of COVID-19, less than 30 cases that fill the diagnostic criteria for post-viral ReA caused by SARS-CoV-2 have been reported, and the exact mechanism of this condition is still a topic for discussion [ 17 , 25 , 26 ]. Cellular immunity to COVID-19 is marked by a strong CD4+ TH1 cell response, secreting high levels of IFN-γ [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic considerations in the clinical management of sudden swelling of the knee: a case report and review of the literature

Pavelić,

Glavaš Weinberger,

Čemerin

et al. 2024

J Med Case Reports

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Background Reactive arthritis and septic arthritis rarely present concomitantly in the same joint and patient. Reactive arthritis presenting after coronavirus disease 2019 is also exceedingly rare, with less than 30 cases reported thus far. Less common pathogens such as Clostridium difficile have been reported to cause reactive arthritis, especially in patients with a positive human leukocyte antigen B27, and therefore should be considered in diagnostic algorithms. The aim of this case report is to highlight the difficulties and precautions in discerning and diagnosing patients presenting with sudden swelling of the knee. Case presentation We report the case of a 70-year-old Caucasian male with a recent history of coronavirus disease 2019 upper respiratory infection and diarrhea and negating trauma, who presented with a swollen and painful knee. Pain and swelling worsened and inflammatory parameters increased after an intraarticular corticosteroid injection. The patient was therefore treated with arthroscopic lavage and intravenous antibiotics for suspected septic arthritis. Synovial fluid and synovium samples were taken and sent for microbiological analysis. Synovial fluid cytology showed increased leukocytes at 10,980 × 106/L, while polymerase chain reaction and cultures came back sterile. Clostridium difficile toxin was later detected from a stool sample and the patient was treated with oral vancomycin. The patient was tested for the presence of human leukocyte antigen B27, which was positive. We present a review of the literature about the challenges of distinguishing septic from reactive arthritis, and about the mechanisms that predispose certain patients to this rheumatological disease. Conclusions It is still a challenge to differentiate between septic and reactive arthritis of the knee, and it is even more challenging to identify the exact cause of reactive arthritis. This case report of a human leukocyte antigen-B27-positive patient highlights the necessity of contemplating different, less common causes of a swollen knee joint as a differential diagnosis of an apparent septic infection, especially in the coronavirus disease 2019 era. Treating the patient for septic arthritis prevented any possible complications of such a condition, while treating the C. difficile infection contributed to the substantial relief of symptoms.

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“…Causative agents of ReA are most commonly genitourinary (Ct, Neisseria gonorrhea , Mycoplasma hominis , and Ureaplasma urealyticum ) or gastrointestinal ( Salmonella , Shigella , Campylobacter , and Yersinia ) 5,6 . Bacillus Calmette‐Guérin (BCG) therapy 7 or viral triggers can also induce ReA 8,9 …”

Section: Discussionmentioning

confidence: 99%

“…5,6 Bacillus Calmette-Guérin (BCG) therapy 7 or viral triggers can also induce ReA. 8,9 ReA commonly affects young adults of 20-40 years, with a male predominance in the postvenereal form. 2 The risk of developing ReA after genitourinary or gastrointestinal infections is about 1%-4% in the general population.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous and rheumatological manifestations of reactive arthritis: A case report

Slouma

Dhia

Dhahri

et al. 2022

Clinical Case Reports

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Reactive arthritis (ReA) is aseptic arthritis occurring 1-4 weeks after bacterial infection of the genitourinary and digestive tracts. 1 It usually affects a genetically predisposed individual. Clinical manifestations include mucocutaneous manifestations such as keratoderma blenorrhagicum, circinate balanitis, ulcerative vulvitis, nail changes (dystrophy and thickness), oral lesions, and conjunctivitis. 2,3 The main rheumatological manifestations are asymmetric oligoarticular arthritis of the lower limbs, enthesitis, dactylitis, and inflammatory back pain.The diagnosis of ReA is challenging since no diagnosis criteria are available. We report a case of ReA occurring

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Post-COVID-19 reactive arthritis

Cited by 5 publications

References 12 publications

Is Recovery Just the Beginning? Persistent Symptoms and Health and Performance Deterioration in Post-COVID-19, non-hospitalised University Students - A Cross-Sectional Study

Is Recovery Just the Beginning? Persistent Symptoms and Health and Performance Deterioration in Post-COVID-19, non-hospitalised University Students - A Cross-Sectional Study

Diagnostic considerations in the clinical management of sudden swelling of the knee: a case report and review of the literature

Cutaneous and rheumatological manifestations of reactive arthritis: A case report

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